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Medical cyanoacrylate adhesive

A cyanoacrylate and adhesive technology, which is applied in surgical adhesives, applications, medical science, etc., can solve the problems affecting the effect of medical adhesives, application promotion, side effects, etc. High junction strength and good toughness of adhesive film

Active Publication Date: 2014-02-19
DALIAN HEYUAN MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, during the storage and use of cyanoacrylate medical adhesives, the production of formaldehyde has side effects on biological tissues, and the damage to organisms increases with the increase of formaldehyde concentration, which seriously affects the effect and application of medical adhesives.

Method used

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  • Medical cyanoacrylate adhesive
  • Medical cyanoacrylate adhesive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] In parts by mass, 6 parts of polylactic acid and casein (mass ratio 0.4-0.6:0.6-0.4) were dissolved in 94 parts of chloroform solvent, and 2-4 parts of sodium sulfite powder were added under high-speed stirring to form a dispersed phase. Spray drying to form microcapsules, washing and drying to form microsphere capsules of 0.01-500 microns, which are used as formaldehyde inhibitors.

[0016] Accurately weigh and mix 95 parts of n-butyl α-cyanoacrylate and 2 parts of acetyl triethyl citrate according to the mass ratio, add 2 parts of formaldehyde inhibitor and 0.1 part of hydroquinone and stir thoroughly, then add 0.9 parts of sulfur dioxide stabilizer parts to prepare cyanoacrylate medical glue. The performance and clinical research results of medical adhesives show that the formaldehyde content of medical adhesives is 20ppm, the bonding strength is 48N, the flexibility can meet the requirements, the cytotoxicity is qualified, the intradermal irritation is qualified, th...

Embodiment 2

[0018] Accurately weigh and mix 91 parts of α-isobutyl cyanoacrylate and 4 parts of triethyl citrate according to the mass ratio, add 4 parts of formaldehyde inhibitor and 0.2 parts of hydroquinone and stir thoroughly, then add 0.8 parts of sulfur dioxide stabilizer , to prepare cyanoacrylate medical glue. The performance and clinical research results of medical adhesives show that the formaldehyde content of medical adhesives is 15ppm, the bonding strength is 55N, the flexibility can meet the requirements, the cytotoxicity is qualified, the intradermal irritation is qualified, and the allergy is qualified. The adhesive has little irritation to biological tissues. Meet the requirements of clinical medical glue.

Embodiment 3

[0020] Accurately weigh and mix 86 parts of ethyl α-cyanoacrylate and 7 parts of tributyl citrate according to the mass ratio, add 6 parts of formaldehyde inhibitor and 0.4 parts of hydroquinone and stir thoroughly, then add 0.6 parts of sulfur dioxide stabilizer, Prepare cyanoacrylate medical glue. The performance and clinical research results of medical adhesives show that the formaldehyde content of medical adhesives is 10ppm, the bonding strength is 46N, the flexibility can meet the requirements, the cytotoxicity is qualified, the intradermal irritation is qualified, and the allergy is qualified. The adhesive has little irritation to biological tissues. Meet the requirements of clinical medical glue.

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Abstract

The invention discloses a medical cyanoacrylate adhesive. The medical cyanoacrylate adhesive comprises the following components in percentage by weight: 80-95% of cyanoacrylate, 2-10% of citrate, 2-8% of a formaldehyde inhibitor, 0.1-0.5% of hydroquinone, and 0.1-1.0% of a sulfur dioxide stabilizer; a preparation method for the formaldehyde inhibitor is as follows: 6 parts of polylactic acid and casein (the mass ratio is (0.4-0.6) : (0.6-0.4) by weight are dissolved in 94 parts of chloroform solvent; 2-4 parts of sodium sulfite powder are added under the high speed stirring to form a dispersion phase to prepare microcapsules by spraying and drying; 0.01-500 microns of microsphere capsules are prepared after water washing and drying and used as the formaldehyde inhibitor. The medical cyanoacrylate adhesive disclosed by the invention effectively restrains the formaldehyde generation through the preparation of the formaldehyde inhibitor, and has the advantages of low formaldehyde concentration, high adhesive strength, good toughness of an adhesive film and little irritation to tissues.

Description

technical field [0001] The invention relates to a medical adhesive, in particular to a cyanoacrylate medical adhesive. Background technique [0002] With the advancement of medicine, the clinical requirements for the effect of surgical techniques and auxiliary materials are getting higher and higher. The philosophy of modern medicine is to minimize the pain of the patient, to allow the patient to recover as quickly as possible, and to restore the function to the greatest extent while also restoring the appearance perfectly. Therefore, the continuous increase of clinical demand has promoted the development of medical adhesive research and the clinical application of adhesive technology. Millions of surgical operations are performed every year in the world. Surgical sutures and fibers are traditionally used to suture surgical wounds. Complications due to air and body fluid leakage are common, and medical adhesives make up for them very well. flaws and are widely used. In th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/04A61L24/00
Inventor 刘彦军郭寅孟吉
Owner DALIAN HEYUAN MEDICAL DEVICES
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