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Method for using emulsion electrospinning method to prepare biodegradable polymer nanofiber membrane

A biodegradable polyester and biodegradable technology, applied in the field of emulsion electrospinning to prepare biodegradable polymer nanofiber membranes, can solve the problems of inability to prepare nanofiber membranes and functional fiber membranes, and achieve the effect of improving spinnability

Active Publication Date: 2014-02-12
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are some biodegradable polymer varieties that cannot be prepared by traditional electrospinning technology to prepare nanofiber membranes and their corresponding functional fiber membranes, such as polybutylene succinate (PBS)

Method used

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  • Method for using emulsion electrospinning method to prepare biodegradable polymer nanofiber membrane
  • Method for using emulsion electrospinning method to prepare biodegradable polymer nanofiber membrane
  • Method for using emulsion electrospinning method to prepare biodegradable polymer nanofiber membrane

Examples

Experimental program
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Effect test

Embodiment 1

[0024] The preparation of biodegradable polyester fiber membrane by emulsion electrospinning method comprises the following steps:

[0025] Weigh 0.6g of PBS and dissolve it in 4ml of chloroform solution, stir until PBS is completely dissolved; take 5mg of sodium lauryl sulfate and dissolve it in 1ml of water to obtain a SDS aqueous solution with a concentration of 0.005g / ml; take 0.2ml of SDS aqueous solution under magnetic stirring Disperse in 4ml PBS chloroform solution under the action of electrospinning, obtain electrospinning emulsion; Carry out electrospinning, voltage 20KV, syringe pump propulsion speed 50ul / min, receiving distance 15cm, spinneret hole diameter 0.5mm, receive with aluminum foil, obtain emulsion electrospinning Spun PBS nanofiber membrane (as figure 1 shown), vacuum dried for 24 hours and sealed for storage.

Embodiment 2

[0027] The preparation of biodegradable polyester fiber membrane by emulsion electrospinning method comprises the following steps:

[0028] Weigh 0.5g of PLGA and dissolve it in 4ml of chloroform solution, stir until PLGA is completely dissolved; take 5mg of glyceryl monostearate and dissolve it in 1ml of chloroform to obtain a monoglyceride chloroform solution with a concentration of 0.005g / ml; take 0.1ml of monoglyceride The chloroform solution of glyceride, 0.1ml water and 4ml PLGA chloroform solution were mixed, and the electrospun emulsion was obtained under the action of magnetic stirring; electrospinning was carried out, the voltage was 15KV, the advancing speed of the syringe pump was 30ul / min, the receiving distance was 10cm, and the spinneret hole 0.2 mm in diameter, received with aluminum foil, to obtain electrospun PLGA nanofiber membranes (such as figure 2 shown), vacuum dried for 24 hours and sealed for storage.

Embodiment 3

[0030] Emulsion electrospinning method prepares the PLA fiber membrane material of loading gentamicin sulfate, comprises the following steps:

[0031]Weigh 0.4g PLA and dissolve it in 4ml chloroform solution, stir until the PLA is completely dissolved; take 0.05mg methylcellulose and 0.5g gentamicin sulfate and dissolve it in 10ml water to obtain an aqueous solution of gentamicin sulfate with a concentration of 5%. Get this solution 0.2ml and join in the chloroform solution of 4ml PLA, stir rapidly so that the aqueous solution is dispersed in the chloroform solution in the form of small droplets, form electrospinning emulsion, carry out electrospinning, voltage 15KV, syringe pump propulsion speed 40ul / min, receiving distance 10cm, spinneret hole diameter 0.2mm, receive with aluminum foil, obtain the PLA nanofiber membrane of loading gentamicin sulfate (such as image 3 shown), vacuum dried for 24 hours and sealed for storage. The loading of gentamicin sulfate can be measured...

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Abstract

The invention discloses a method for using an emulsion electrospinning method to prepare a biodegradable polymer nanofiber membrane. The method includes preparing a biodegradable polymer solution with concentration of 0.05-0.2g / ml; mixing the biodegradable polymer solution with incompatible liquid and a surfactant, wherein volume ratio between the biodegradable polymer solution and the incompatible liquid is 1:50-1:10, stirring to obtain emulsion, and performing electrostatic spinning on the emulsion to obtain the biodegradable polymer nanofiber membrane. The method is simple and easy to implement and low in equipment cost, does not require to form completely-homogeneous electrospinning liquid, and is wider in application range when compared with conventional solution electrospinning technology, and structure and performance of the polymer fiber membrane can be further controlled by controlling property of the emulsion.

Description

technical field [0001] The invention belongs to the field of nanofibers, in particular to the preparation of biodegradable polymer nanofiber membranes by emulsion electrospinning. Background technique [0002] Electrospinning, referred to as electrospinning, is a technology that stretches and deforms a polymer solution or melt through an electric field force applied by high-voltage static electricity, and forms fibers with the process of solvent volatilization or melt solidification. Simple and efficient method for micron-to-nanoscale polymer fibers. [0003] Emulsion electrospinning is a new type of electrospinning technology with special application value and prospects developed on the basis of traditional electrospinning. Emulsion electrospinning is a method in which polymer solution is emulsified to replace the original uniform and clear solution for electrospinning, and polymer nanofibers are prepared. It is a thermodynamically unstable dispersion system formed by two...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D04H1/4382D01D5/00
Inventor 王萍丽田利刚季君晖
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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