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Fabrication of Biodegradable Polymer Nanofiber Membranes by Emulsion Electrospinning

A biodegradable polyester and biodegradable technology is applied in the field of preparing biodegradable polymer nanofiber membranes by emulsion electrospinning, which can solve the problems of inability to prepare nanofiber membrane functional fiber membranes, and achieve the effect of improving spinnability

Active Publication Date: 2016-06-08
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are some biodegradable polymer varieties that cannot be prepared by traditional electrospinning technology to prepare nanofiber membranes and their corresponding functional fiber membranes, such as polybutylene succinate (PBS)

Method used

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  • Fabrication of Biodegradable Polymer Nanofiber Membranes by Emulsion Electrospinning
  • Fabrication of Biodegradable Polymer Nanofiber Membranes by Emulsion Electrospinning
  • Fabrication of Biodegradable Polymer Nanofiber Membranes by Emulsion Electrospinning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation of biodegradable polyester fiber membrane by emulsion electrospinning method comprises the following steps:

[0025] Weigh 0.6g PBS and dissolve it in 4ml chloroform solution, stir until PBS is completely dissolved; take 5mg sodium lauryl sulfate and dissolve it in 1ml water to obtain an SDS aqueous solution with a concentration of 0.005g / ml; take 0.2ml SDS aqueous solution under the action of magnetic stirring Dispersed in 4mlPBS chloroform solution under low pressure to obtain electrospun emulsion; carry out electrospinning, voltage 20KV, syringe pump propulsion speed 50ul / min, receiving distance 15cm, spinneret hole diameter 0.5mm, receive with aluminum foil, obtain emulsion electrospun PBS Nanofibrous membranes (such as figure 1 shown), vacuum dried for 24 hours and sealed for storage.

Embodiment 2

[0027] The preparation of biodegradable polyester fiber membrane by emulsion electrospinning method comprises the following steps:

[0028] Weigh 0.5g of PLGA and dissolve it in 4ml of chloroform solution, stir until PLGA is completely dissolved; take 5mg of glyceryl monostearate and dissolve it in 1ml of chloroform to obtain a monoglyceride chloroform solution with a concentration of 0.005g / ml; take 0.1ml of monoglyceride The chloroform solution of the ester, 0.1ml of water and 4ml of PLGA chloroform solution were mixed, and the electrospun emulsion was obtained under the action of magnetic stirring; electrospinning was carried out, the voltage was 15KV, the advancing speed of the syringe pump was 30ul / min, the receiving distance was 10cm, and the diameter of the spinneret hole was 0.2 mm, received as aluminum foil to obtain electrospun PLGA nanofibrous membranes (eg figure 2 shown), vacuum dried for 24 hours and sealed for storage.

Embodiment 3

[0030] Emulsion electrospinning method prepares the PLA fiber membrane material of loading gentamicin sulfate, comprises the following steps:

[0031] Weigh 0.4g PLA and dissolve it in 4ml of chloroform solution, stir until the PLA is completely dissolved; take 0.05mg of methylcellulose and 0.5g of gentamicin sulfate and dissolve it in 10ml of water to obtain an aqueous solution of gentamicin sulfate with a concentration of 5%; Take 0.2ml of this solution and add it to the chloroform solution of 4ml PLA, stir rapidly so that the aqueous solution is dispersed in the chloroform solution in the form of small droplets to form an electrospinning emulsion, and perform electrospinning with a voltage of 15KV and a syringe pump with a speed of 40ul / min. The receiving distance is 10cm, the diameter of the spinneret hole is 0.2mm, and it is received with aluminum foil to obtain a PLA nanofiber membrane loaded with gentamicin sulfate (such as image 3shown), vacuum dried for 24 hours and ...

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Abstract

The invention discloses the preparation of a biodegradable polymer nanofiber membrane by an emulsion electrospinning method; by preparing a biodegradable polymer solution with a concentration of 0.05-0.2 g / ml, the volume ratio of the biodegradable polymer solution to the biodegradable polymer solution is 1: 50~1:10 incompatible liquid and surfactant are mixed and stirred to obtain an emulsion, and the emulsion is subjected to electrospinning to obtain a biodegradable polyester fiber membrane; The completely homogeneous electrospinning solution has a wider application range than the traditional solution electrospinning technology, and can further regulate the structure and performance of the polymer fiber membrane by adjusting the properties of the emulsion.

Description

technical field [0001] The invention belongs to the field of nanofibers, in particular to the preparation of biodegradable polymer nanofiber membranes by emulsion electrospinning. Background technique [0002] Electrospinning, referred to as electrospinning, is a technology that stretches and deforms a polymer solution or melt through an electric field force applied by high-voltage static electricity, and forms fibers with the process of solvent volatilization or melt solidification. Simple and efficient method for micron-to-nanoscale polymer fibers. [0003] Emulsion electrospinning is a new type of electrospinning technology with special application value and prospects developed on the basis of traditional electrospinning. Emulsion electrospinning is a method in which polymer solution is emulsified to replace the original uniform and clear solution for electrospinning, and polymer nanofibers are prepared. It is a thermodynamically unstable dispersion system formed by two...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/728D04H1/4382D01D5/00
Inventor 王萍丽田利刚季君晖
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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