New crystal form of prasugrel and preparation method thereof
A technology of prasugrel and crystal form, which is applied in the field of medicine and chemical industry, can solve the problems that prasugrel free base is not suitable for drug synthesis, and achieve the effects of shortening the production route, simple preparation process and equivalent dissolution rate
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Embodiment 1
[0055] Example 1 Preparation of prasugrel M crystal form
[0056] Add 2 grams of prasugrel crude product into 6ml 1,4-dioxane, heat to 30 degrees to dissolve, slowly cool down to room temperature under stirring condition, a white solid precipitates, continue to stir for 2 hours, filter to obtain white crystals, Vacuum dried to obtain 1.71 g of the product, with a yield of 85.5%.
Embodiment 2
[0057] Example 2 Preparation of prasugrel M crystal form
[0058] Add 2 grams of prasugrel crude product into 6ml tetrahydrofuran, heat to 30 degrees to dissolve, slowly cool down to room temperature under stirring condition, a white solid precipitates out, continue to stir for 0.5 hours, filter to obtain white crystals, and vacuum dry to obtain the product 1.58 grams, yield 79.0%.
Embodiment 3
[0059] Example 3 Preparation of prasugrel N crystal form
[0060] Add 2 grams of prasugrel crude product to 10ml of a mixed solvent of methyl ethyl ketone:petroleum ether=1:2, heat to 80 degrees to dissolve, let it stand and slowly cool down to room temperature, a white solid precipitates, grow crystals for 2 hours, filter to obtain White crystals were vacuum-dried to obtain 1.66 g of the product, with a yield of 83.1%.
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