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Applications of chaetocin in preparing medicament for preventing and treating diabetes

A kind of diabetes medicine, the technology of chaetocin, which is applied to the application of chaetocin in the preparation of medicines for preventing and treating diabetes, and the field of chaetocin compounds, can solve the problems such as no research reports, and achieve the enhancement of immune function, the reduction of blood sugar and blood lipids, the blood sugar lowering effect

Inactive Publication Date: 2014-02-05
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the early days, there were reports that chaetin was used to prevent and treat tumor diseases, but there was no research report on the use of chaetin in the prevention and treatment of diabetes

Method used

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  • Applications of chaetocin in preparing medicament for preventing and treating diabetes
  • Applications of chaetocin in preparing medicament for preventing and treating diabetes
  • Applications of chaetocin in preparing medicament for preventing and treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 The protective effect of Chaetocin on diet-induced diabetes

[0041] 1. Experimental group:

[0042]SPF male C57BL / 6 mice (purchased from the Institute of Model Animals, Nanjing University) were selected and randomly divided into three groups for 4-6 weeks: control diet group (Control), high-fat diet group (HighFatDiet, HFD), and high-fat diet group +Chaetocin group (HFD+Chaetocin), 3-4 animals in each group. The special feed was purchased from Reaearch Diets Inc., the item number of the control feed was D12329, and the item number of the experimental group feed was D12331. In order to establish the diabetes model, the mice were continuously fed with the feed for 12-16 weeks respectively.

[0043] 2. Experimental method:

[0044] Chaetocin was administered at a concentration of 0.5 mg / kg and administered by intraperitoneal injection every two days until 13 weeks. The body weight of the mice was tracked and recorded every week, and the blood glucose of the m...

Embodiment 2

[0058] Example 2 Experiment on the protective effect of Chaetocin on diabetes caused by gene defects

[0059] 1. Experimental group:

[0060] SPF grade male db / db mice (purchased from the Institute of Model Animals, Nanjing University) were selected and randomly divided into three groups for 6-8 weeks: control group (Control), low-dose chaetocin group (LowChaetocin), high-dose chaetocin group Vegetarian group (HighChaetocin), 7-8 in each group. To construct a diabetes model, mice can be given normal feed, and administered by intraperitoneal injection every two days. The concentration of Chaetocin is low concentration: 0.1mg / kg; high concentration: 0.5mg / kg, which lasts until 6 weeks.

[0061] 2. Experimental method:

[0062] The body weight of the mice was tracked and recorded every week, and the blood glucose of the mice was tracked and measured until 4 weeks to identify whether the model was successfully constructed. Experiments were carried out from the 5th week to detec...

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Abstract

The invention discloses applications of chaetocin in preparing medicament for preventing and treating diabetes. Experimental study proves that the chaetocin can notably protect pancreas islet B cell, maintain the steady state of glycolipid, improve the insulin resistance, enhance the sensitivity of an organism on insulin, and can improve the gluconeogenesis process of the organism; the chaetocin can reduce the level of cholesterin and glycerin trilaurate in blood and improve the activity of glutamic-pyruvic transaminase and has a good effect of preventing and treating diabetes, obvious untoward reaction is not seen in the experimental process, and the chaetocin is hopefully developed into a new-generation safety and effective medicament for preventing and treating diabetes.

Description

technical field [0001] The invention relates to chaetocin compounds, in particular to the application of chaetocin in the preparation of medicines for preventing and treating diabetes, and belongs to the field of pharmaceutical preparations. Background technique [0002] Diabetes mellitus is a common endocrine and metabolic disease mainly characterized by glucose metabolism disorders. Its cause is not yet fully understood. The main pathophysiological changes are insufficient insulin secretion or action defects, which prevent glucose from being utilized by the body, causing metabolic disorders such as sugar, protein, fat, water, and electrolytes. In recent years, with the improvement of people's living standards, changes in lifestyle and population aging, the prevalence of diabetes is increasing year by year, which is called the "epidemic" of the 21st century. According to the statistics of the International Diabetes Federation (IDF), there were 151 million diabetic patient...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/548A61P3/10
Inventor 徐涌孙丽娜陈俊良
Owner NANJING MEDICAL UNIV
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