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Process for producing medical dried yeast powder

A production process and technology of dry yeast powder, which is applied in powder transportation, drug combination, pharmaceutical formula, etc., can solve the problems of dry yeast powder nutrient element destruction and long production cycle, so as to promote yeast autolysis, reduce drying temperature, reduce Effect of autolysis temperature and time

Active Publication Date: 2015-02-18
HUNAN XIANGYIKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] But above-mentioned prior art exists the problem such as the nutrient element destruction of dry yeast powder that the production period is long, autolysis temperature and drying temperature are high.

Method used

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  • Process for producing medical dried yeast powder

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Experimental program
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Effect test

Embodiment 1

[0026] Put 100.0 kg of active brewer's yeast into 300 kg of drinking water, stir and wash for 30 minutes, then centrifuge and dehydrate, disperse the filter cake in 200 kg of drinking water, add NaOH to adjust the pH to 8.5, centrifuge and wash to neutral, and the obtained 95 Disperse kg of filter cake in 95 kg of purified water, add 0.5 kg of lysozyme, 0.3 kg of mannitolase, and 2.0 kg of a mixture of sodium lauryl sulfate and potassium bicarbonate, heat up to 45°C, react for 6 h, and then add ethanol 10.0 kg, after stirring for 30 minutes, put the colloid solution into the supercritical reactor, control the pressure of the reactor to 10 MPa, the temperature is 50 °C, and the gaseous CO containing solvent 2 The flow rate was 20 L / min. After drying for 2 hours, the obtained material was powdered and passed through a 50-mesh sieve to obtain 56.4 kg of finished product, with a yield of 56.4%. The obtained product has a water content of 1.5% and a protein content of 54%.

Embodiment 2

[0028] Put 100.4 kg of active brewer's yeast into 300 kg of drinking water, stir and wash for 30 minutes, then centrifuge and dehydrate, disperse the filter cake in 200 kg of drinking water, add NaOH to adjust the pH to 8.5, centrifuge and wash to neutral, and the obtained 92 kg Disperse the filter cake in 92 kg of purified water, add 0.4 kg of helicase, 0.4 kg of mannitolase, 2.0 kg of a mixture of sodium lauryl sulfate and potassium bicarbonate, raise the temperature to 50°C, and react for 6 h, then add 10.0 kg of ethanol kg, after stirring for 30 minutes, put the colloidal solution into the supercritical reactor, control the pressure of the reactor to 10 MPa, the temperature to 50°C, and the solvent-containing gaseous CO 2 The flow rate was 20 L / min. After drying for 2 hours, the obtained material was powdered and passed through a 50-mesh sieve to obtain 53.7 kg of finished product, with a yield of 53.5%. The obtained product has a water content of 1.8% and a protein conten...

Embodiment 3

[0030] Put 500.0 kg of active brewer's yeast into 1,500 kg of drinking water, stir and wash for 30 minutes, then centrifugally dehydrate, disperse the filter cake in 1,000 kg of drinking water, add NaOH to adjust the pH to 8.0, and wash with centrifugal water until neutral, and the obtained 465 Disperse kg of filter cake in 465 kg of purified water, add 5 kg of β-1,3-glucanase, 1.5 kg of mannosidase, 10 kg of a mixture of sodium lauryl sulfate and potassium bicarbonate, heat up to 50°C, and react After 7 h, 60.0 kg of ethanol was added, stirred for 30 minutes, and the colloidal solution was poured into a supercritical reactor. The pressure of the reactor was controlled at 12 MPa and the temperature was 50 °C. 2 The flow rate was 50 L / min. After drying for 2.5 hours, the obtained material was powdered and passed through a 50-mesh sieve to obtain 276.0 kg of finished product, with a yield of 55.2%. The obtained product has a water content of 1.8% and a protein content of 55%.

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Abstract

The invention discloses a process for producing medical dried yeast powder, and belongs to the technical field of medicine synthesis. The process comprises the following steps: washing and centrifuging active beer yeast; diluting with water; deacidifying and centrifuging, and adding purified water, lyticase and composite accelerant; heating for self-dissolution; adding ethanol; drying with supercritical fluid CO2; powdering and screening to prepare a finished product. In the medical dried yeast powder, the moisture is lower than 2 percent, and the content of protein is 52-57 percent. The process is short in process time consumption and low in production temperature, and is applicable to production of uniform and high-quality medical dried yeast powder.

Description

technical field [0001] The invention relates to a production process of medicinal dry yeast powder, which belongs to the technical field of medicine synthesis. Background technique [0002] Dry yeast is the dry cell of beer yeast, which contains a variety of amino acids, vitamins, cellulose and other nutrients. It is often made into tablets and used for malnutrition, indigestion, loss of appetite and B vitamin deficiency, such as beriberi and conjunctivitis. Prevention and treatment of multiple neuritis, pellagra, etc. [0003] The production process of dry yeast is included in the "National Compilation of Raw Materials Processes". This process consists of three generations of fermentation of the original strain, and the obtained fresh yeast is autolyzed at 75°C to 90°C to obtain a yeast slurry, and finally sprayed Dry to obtain the finished medicinal yeast powder. [0004] In the production method of a kind of high-quality beer yeast powder disclosed by CN1031857A, th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/064A61K9/14A61K47/20A61K47/02A61P3/02A61P1/14A61P25/00A61P17/00
Inventor 帅放文王向峰章家伟
Owner HUNAN XIANGYIKANG PHARMA
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