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Method of using rhein for treating fibrotic conditions and tumors

A technology for pancreatic tumors and diseases, applied in the field of preparation of anti-fibrosis agents, which can solve the problems of high malignancy, low curative effect, and poor prognosis

Active Publication Date: 2014-01-15
HONG KONG BAPTIST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

PDAC is the most common malignant tumor with extremely high malignancy, low curative effect of surgical resection and chemotherapy and radiotherapy, and poor prognosis

Method used

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  • Method of using rhein for treating fibrotic conditions and tumors
  • Method of using rhein for treating fibrotic conditions and tumors
  • Method of using rhein for treating fibrotic conditions and tumors

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Embodiment Construction

[0047] The present invention relates to an anthraquinone derivative of structural formula 1, namely 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, also known as rhein:

[0048]

[0049] The compound can be extracted from the root of Polygonaceae (Rhubarb) by water extraction and solvent evaporation. According to the Chinese Pharmacopoeia, this rhubarb extract is yellow and crystalline, and it has been used since ancient times as a mild laxative as well as a hemostatic agent. In the present invention, rhein powder was purchased from Nanjing Zelang Medical Technology Company Limited and proved to have a purity of ≥98%.

[0050] In an embodiment, the mice injected with bombesin are gavaged with rhein at a sufficient dose (i.e. 50 mg / kg) every day (the daily single dose of rhein on mice is 50 mg / kg, calculated according to the dose coefficient, and the dose The conversion factor is 12.33, which is equivalent to the human dose of 4mg / kg). After six weeks, t...

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Abstract

The present invention relates to a method of using an anthraquinone derivative namely 9,10-Dihyro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, or known as Rhein, for treating chronic pancreatitis induced fibrosis of the pancreas. More particularly, the present invention relates to a method of using Rhein, its derivatives and / or chemical variants as an anti-fibrotic agent. The present invention particularly relates to the suppression of pancreatic stellate cell activation for the management of chronic inflammatory, fibrotic and tumorigenic pathologies in the pancreas.

Description

[0001] Cross References to Related Applications [0002] This patent application claims priority to US Provisional Patent Application No. 61 / 655,472, filed June 4, 2012, the disclosure of which is hereby incorporated by reference in its entirety. technical field [0003] The invention relates to the application of rhein in the treatment of chronic pancreatitis and its induced pancreatic fibrosis. In particular, the present invention relates to the use of an anthraquinone derivative, namely 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid (also known as rhein) as or Application of preparation of anti-fibrosis agent. The present invention particularly relates to the application of rhein in inhibiting the activation of pancreatic stellate cells to control chronic inflammatory lesions, fibrotic lesions and tumor lesions of the pancreas. Background technique [0004] Pancreatic fibrosis is a typical histopathological feature in chronic pancreatitis and, in fac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/192A61P1/18A61P35/00
CPCA61K36/708A61K31/192A61P1/18A61P35/00A61K2300/00
Inventor 卞兆祥曾少慧吕爱平肖海涛秦红岩陈新滋徐宏喜陈士林杨大坚
Owner HONG KONG BAPTIST UNIV
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