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Synthetic vitreous material

A technology of artificial glass and body materials, applied in the direction of prosthetics, peptides, polymer compounds, etc., which can solve the problems of increased burden on the eyeball and longer time required for treatment, so as to prevent the reduction of drug delivery effect, Excellent drug retention and excellent operability

Inactive Publication Date: 2014-01-08
MENICON CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the burden on the eyeball may become larger, and the time required for treatment may also be longer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Mix the self-assembled peptide (manufactured by Meirikang Co., Ltd., product name: PanaceaGel SPG-178, 1w / v%) with distilled water (manufactured by Otsuka Pharmaceutical Works Co., Ltd., product name: Jufang Otsuka Distilled Water) to obtain a peptide concentration of 0.15 w / v% peptide in water. The obtained peptide aqueous solution and saline solution 1 (manufactured by Showa Pharmaceutical Co., Ltd., diluent for Opeaka (registered trademark) (octane glutathione solution), osmotic pressure: 308mOsm / kg) were mixed at a volume ratio of 2:1 to obtain Artificial vitreous materials1. Table 1 shows the self-assembling peptide concentration, the ratio of the saline solution, and the osmotic pressure in the obtained artificial vitreous material.

Embodiment 2

[0089] Except for using saline solution 2 (manufactured by Nippon Alcon Co., Ltd., trade name: diluent for BSS Plus (registered trademark) (octane glutathione solution), osmotic pressure: 308 mOsm / kg) instead of saline solution 1, the same as in Example 1, the artificial vitreous body material 2 was obtained in the same manner. Table 1 shows the self-assembling peptide concentration, the ratio of the saline solution, and the osmotic pressure in the obtained artificial vitreous material.

Embodiment 3

[0091] Artificial vitreous material 3 was obtained in the same manner as in Example 2, except that the peptide concentration of the peptide aqueous solution was 0.45 w / v%. Table 1 shows the self-assembling peptide concentration, the ratio of the saline solution, and the osmotic pressure in the obtained artificial vitreous material.

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Abstract

A synthetic vitreous material which is capable of maintaining a tamponade effect in the eye on a long-term basis without toxicity to ocular tissue, and has excellent operability, is provided. This synthetic vitreous material contains self-assembling peptides and salt, and has an osmolarity of 40 mOsm / kg to 200 mOsm / kg. This synthetic vitreous material is capable of maintaining a tamponade effect in the eye on a long-term basis without toxicity to ocular tissue, and has excellent operability.

Description

technical field [0001] The present invention relates to artificial vitreous materials. Background technique [0002] The vitreous humor is a gel-like substance made of collagen and sodium hyaluronate that fills the posterior cavity of the eyeball. The vitreous has a packing effect that presses against the retina from the inside of the eyeball to prevent it from peeling off. Therefore, it is an important tissue for the normal function of the eyeball. At present, vitrectomy is mostly performed for retinal vitreous diseases that require surgical treatment. However, since there is no suitable vitreous substitute, the vitreous body has been removed after vitrectomy. In addition, it has also been reported that after vitrectomy, the efficacy of intraocular administration by injection is reduced compared to the case where the vitreous is present. [0003] Gases (for example, air, expansion gas such as sulfur hexafluoride, or octafluoropropane), silicone oil, and liquid perfluoroc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00C07K7/08
CPCA61L27/52A61L27/227A61L2400/06A61L2430/16C07K7/08A61K9/0051A61K47/42
Inventor 上杉晃司林龙平林田康隆马场耕一西田幸二
Owner MENICON CO LTD
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