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Absorbable and degradable multipurpose biocompatible material

A biocompatible and multi-purpose technology, used in absorbent pads, medical science, prostheses, etc., can solve the problem of poor tissue adhesion between gelatin sponge and collagen sponge, poor biocompatibility and hemostatic function, and obvious wound scars. and other problems, to achieve good absorbability and degradability, eliminating hidden dangers of viruses, and good anti-inflammatory effect.

Active Publication Date: 2014-01-01
HANGZHOU YINGJIAN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, conventional hemostatic materials such as fibrin glue, gelatin sponge, medical gauze, collagen sponge, etc., but they each have certain shortcomings: the tissue adhesion of gelatin sponge and collagen sponge is poor, and the hemostatic function of both depends on Due to the sufficient amount of platelets and coagulation factors, the application is limited. Fibrin glue comes from the blood, which may cause viral infection. Medical gauze not only has a long healing period and obvious wound scars, but also is easy to stick during dressing changes. causing considerable pain to the patient
However, its biocompatibility and hemostatic function are poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Prepare each raw material into an aqueous solution first: chitosan is prepared into an aqueous solution of chitosan with a mass concentration of 0.4%; collagen is prepared with warm water at 40°C into an aqueous solution of collagen with a mass concentration of 2%; hyaluronic acid is dispersed first In water, after being fully swollen, stir slowly to prepare a hyaluronic acid aqueous solution with a mass concentration of 0.2%.

[0035] (2) First mix 2.5g of collagen aqueous solution and 50g of hyaluronic acid aqueous solution, add 0.04g of EDC, and then add 100g of composite solvent. The composite solvent is composed of ethanol, propylene glycol and dipropylene glycol. The weight ratio of ethanol, propylene glycol and dipropylene glycol is: 4: 0.5:0.5, add 50g of chitosan aqueous solution after stirring evenly, let stand for 2-hours to form hydrogel after stirring evenly, pour the hydrogel into a 300-mesh mesh bag, wash with double distilled water to remove impuritie...

Embodiment 2

[0037] (1) Prepare each raw material into an aqueous solution first: chitosan is prepared into an aqueous solution of chitosan with a mass concentration of 0.6%; collagen is prepared with warm water at 50°C into an aqueous solution of collagen with a mass concentration of 1.5%; hyaluronic acid is first dispersed In water, after being fully swollen, stir slowly to prepare a hyaluronic acid aqueous solution with a mass concentration of 0.4%.

[0038] (2) First mix 10g of collagen aqueous solution and 50g of hyaluronic acid aqueous solution, add 0.18g of EDC, and then add 150g of composite solvent. The composite solvent is composed of ethanol, propylene glycol and dipropylene glycol. The weight ratio of ethanol, propylene glycol and dipropylene glycol is: 4:2:2, stir well and then add 100g chitosan aqueous solution, stir well and let it stand for 3 hours to form a hydrogel, pour the hydrogel into a 400-mesh mesh bag, wash with double distilled water to remove impurities, and final...

Embodiment 3

[0040] (1) Prepare each raw material into an aqueous solution: chitosan is prepared into an aqueous solution of chitosan with a mass concentration of 0.5%; collagen is prepared with warm water at 45°C into an aqueous solution of collagen with a mass concentration of 1.5%; sodium alginate is dissolved in The water is prepared as a sodium alginate aqueous solution with a mass concentration of 2%.

[0041] (2) First mix 20g of collagen aqueous solution with 25g of sodium alginate aqueous solution, add 0.3g of EDC, and then add 160g of composite solvent. The composite solvent is composed of ethanol, propylene glycol and dipropylene glycol. The weight ratio of ethanol, propylene glycol and dipropylene glycol is: 6: 3: 3, add 160g chitosan aqueous solution after stirring evenly, let it stand for 4 hours to form a hydrogel after stirring evenly, pour the hydrogel into a 300-mesh mesh bag, wash with double distilled water to remove impurities, and finally Freeze-dried for 48 hours to ...

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PUM

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Abstract

The invention discloses an absorbable and degradable multipurpose biocompatible material. The raw materials of the absorbable and degradable multipurpose biocompatible material comprise chitosan, collagen and hyaluronic acid or sodium alginate in a weight ratio of (2 to 8): (0.5 to 3): (1 to 5); adding a dehydrating agent; generating hydrogel by a cross-linking reaction; and finally performing freeze-drying to prepare sponge or film. The absorbable and degradable multipurpose biocompatible material disclosed by the invention can be used as a bleeding-stopping anti-adhesion material, good in tissue adhesion, remarkable in anti-adhesion effect, capable of rapidly stopping bleeding, preventing adhesion, promoting tissue healing, preventing rebleeding, eliminating the inevitable virus hidden troubles of gelatine and animal collagen, and greatly improving safety, complete in degradation, capable of being absorbed and utilized by the body, and free of side effects on the body. The absorbable and degradable multipurpose biocompatible material can also be used as a scaffold for tissue engineering, artificial skin and the like, and good in biocompatibility, absorbability and degradability.

Description

technical field [0001] The invention relates to the technical field of medical material production, in particular to an absorbable and degradable multipurpose biocompatible material. Background technique [0002] Postoperative adhesion refers to the abnormal structure formed by the combination of connective tissue fibers and adjacent tissues or organs. It is an inevitable pathophysiological process during postoperative healing. one. Every year, a large number of tissue adhesions occur after surgery, resulting in permanent disability and even life-threatening problems for patients. Surgical trauma, local ischemia, bleeding and bacterial infection may cause postoperative adhesions. According to statistics, the incidence of postoperative adhesion is about 50-90%, and it can also cause serious complications. So far, people are looking for various methods to prevent postoperative adhesions. Adjustment of surgical techniques, use of drugs and anti-adhesion isolation materials ...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08L89/00C08K7/24C08K3/26C08J3/24C08J3/075C08J9/28A61L15/32A61L15/28A61L15/62A61L15/64A61L27/26A61L27/60A61L27/58
Inventor 王春正戴建英
Owner HANGZHOU YINGJIAN BIOTECHNOLOGY CO LTD
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