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Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol

A technology of dianhydrodulcitol and diacetyl, applied in the field of chemical reagents that were previously limited to suboptimal clinical performance, can solve the problem of exhaustion of treatment options

Inactive Publication Date: 2013-12-25
DEL MAR PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For difficult-to-treat cancers, patients are often quickly depleted of treatment options leaving them in a desperate situation requiring additional treatment options

Method used

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  • Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol
  • Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol

Examples

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specific Embodiment

[0603]Specific examples include: fluoropyrimidines; thiopurinol; nucleoside diphosphate reductase inhibitors; 2'-deoxyribonucleoside analogs; nucleosides; folic acid analogs; Norleucine; L-asparaginase; N-(phosphoacetyl)-L-aspartic acid; Enbixin; Dichloroethylmethylamine; Chlorambucil; Melphalan; Cyclophosphine Amides; Estramustine; Platinum complexes; Nitrosoureas; Dichloroethylnitrosourea (BCNU); ); Cyclohexylnitrosourea (CCNU); Streptozotocin; Alkylsulfonates; Busulfan; ); aziridine; tris(1-aziridinyl)phosphine sulfide; aziridine phosphine; 3,6-diaziridine l-2,5-bis(ethoxycarbonyl)-1,4-benzene Diaziquone (AZQ); AZQ analogs; bendamustine (Treanada); procarbazine; hexamethylenetetramine; topoisomerase I inhibitors, including camptothecin and camptothecin-like substances; topoisomerase II inhibitors, including anthracyclines, doxorubicin, epirubicin, podophyllotoxin; DNA intercalators; amsacrine; CI-921 ((9-[[2-methyl Oxy-4-[(methylsulfonyl)amino]phenyl]amino]-N,5-dimethyl-...

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Abstract

The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to substituted hexitols such as dianhydrogalactitol and diacetyldianhydrogalactitol.

Description

[0001] cross reference [0002] This application claims priority to: (1) U.S. Provisional Patent Application No. 61 / 401,705, filed August 18, 2010, by Dr. Dennis Brown, entitled "Compounds for Improving Suboptimal Administration Including Substituted Hexose Sugars Compositions and Methods for Therapeutic Effects of Alcohols such as Vitconol for the Treatment of Benign and Neoplastic Hyperproliferative Diseases"; (2) U.S. Provisional Patent Application No. 61 / 401,706, filed August 18, 2010 by Dr. Dennis Brown Submission entitled "Compositions and methods for improving the therapeutic efficacy of suboptimally administered compounds, including substituted hexitols such as diacetyldianhydrodulcitol, for the treatment of benign and neoplastic hyperproliferative diseases"; (3 ) U.S. Provisional Patent Application No. 61 / 401,707, filed August 18, 2010, by Dr. Dennis Brown, entitled "Compounds for Improving Suboptimal Dosing Including Substituted Hexitols such as Diacetyldianhydro Comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N31/00
CPCA61K31/045A61K31/047A61K31/336A61K31/44A61K31/506A61K31/517A61K31/5377A61K31/7004A61K31/7024A61K45/06A61P7/00A61P9/00A61P13/08A61P17/06A61P19/06A61P31/00A61P31/18A61P35/00A61P35/02A61P37/06A61P43/00
Inventor 丹尼斯·M·布朗
Owner DEL MAR PHARMA
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