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Ibuprofen suspension and preparation method thereof

A kind of suspension and suspension technology, applied in the field of medicine, can solve the problems of easy recurrence and repeated respiratory tract infection in children, and achieve the effect of good stability, not easy to float, and simple and feasible preparation process

Active Publication Date: 2013-12-25
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to solve the treatment of recurrent respiratory tract infection in children, overcome the obvious shortcomings such as the easy recurrence of a single ibuprofen, and achieve the goal of treating both symptoms and root causes

Method used

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  • Ibuprofen suspension and preparation method thereof
  • Ibuprofen suspension and preparation method thereof
  • Ibuprofen suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] To prepare 1000ml of ibuprofen suspension:

[0029] Weigh 20g of ibuprofen, 7.5g of microcrystalline cellulose, 1.5g of gum arabic, 500g of sucrose, 100g of glycerin, 1g of sodium carboxymethylcellulose, 1.6g of lemon flavor, 803g of Tween, 2.5g of sodium benzoate, ethylenediaminetetra Disodium acetate 0.5g, carmine 0.005g, sorbitol solution 100g, citric acid 1.425g

[0030] 1 ibuprofen slurry preparation

[0031] Take the sorbitol solution, glycerin, and sodium carboxymethylcellulose, stir for 10 minutes, and heat to 70° C. until the gum becomes hydrated completely. Then cool the hydrate to 45°C, add Tween 80, when the mixture is cooled to 30°C, continue mixing for about 15 minutes, then add ibuprofen, continue stirring and mixing for 15 minutes;

[0032] 2 Preparation of suspension

[0033] First prepare a 1% aqueous solution of gum arabic. Take 150 mL of water, slowly add 1.5 g of gum arabic, mix for about 25 minutes to make a 1% aqueous solution of gum arabic, a...

Embodiment 2

[0036] A kind of ibuprofen suspension, it is characterized in that main medicine is added in the auxiliary material of medicine, make it suspend, be configured into solution, sterilize, subpackage, described main medicine is prepared from following bulk medicine: ibuprofen 7g, bupleurum 30g, coptis 30g, dandelion 20g, liangmianzhen 15g, pinellia 10g, angelica 10g, ginseng 5g, turmeric 5g, pomegranate peel 3g, licorice 3g.

[0037] The preparation method is:

[0038] 1 Preparation of concentrated solution:

[0039] Take 30g of Bupleurum, 30g of Coptidis, 20g of Dandelion, 15g of Two-faced Acupuncture, 10g of Pinellia, 10g of Angelica, 5g of Ginseng, 5g of Curcuma, 3g of Pomegranate Peel, and 3g of Licorice. , decoct, and filter; waste the dregs, combine the filtrate, evaporate and concentrate under reduced pressure to a concentrated solution with a relative density of 1.10 to 1.15 at 60 to 70°C.

[0040] 2 Preparation of ibuprofen slurry

[0041]Take 100 g of sorbitol liquid...

Embodiment 3

[0047] 1. Toxicity test:

[0048] This experiment adopts healthy SD rats, and the drug dosage gradient prepared by oral administration embodiment 1 and embodiment 2 is 0.1ml / kg and 0.5ml / kg, and it is administered continuously for 30 days. Within 1 week after taking the drug, there was no significant effect on animal growth status, activity and diet, hematology, blood biochemistry, organ tissue structure, and urine routine, which indicated that the clinical drug was safe and reliable.

[0049] 2. Analgesic experiment:

[0050] Effect on the writhing reaction induced by acetic acid in BALB / c mice: 60 BALB / c mice, half male and half male, with an average body weight of 20.3g, were randomly divided into 3 groups, which were respectively normal saline group, the drug group of Example 1, Embodiment 2 drug group; administration once a day, dosage is 0.25ml / kg (experimental group gives medicine, matched group gives the normal saline of equal weight), continuous intragastric administ...

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Abstract

The invention relates to an ibuprofen suspension and a preparation method thereof. The ibuprofen suspension is a Chinese and western compound preparation, a primary medicine of the ibuprofen suspension comprises ibuprofen, the primary medicine is added to auxiliary medicines of the ibuprofen suspension to make the primary medicine suspend in order to prepare a suspension, and the suspension is disinfected and packaged to obtain the ibuprofen suspension. The ibuprofen suspension can simultaneously treat the principle and subordinate symptoms of infantile recurrent respiratory tract infection and infantile fevers, and has the advantages of non-toxicity and innocuousness to human bodies, no side effects, low price, simple preparation and wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an ibuprofen suspension and a preparation method thereof. Background technique [0002] Recurrent respiratory tract infection in children is a common and frequently-occurring disease in clinical practice. Modern medicine believes that the exact pathogenesis is still not completely clear, and it is the result of the combined effect of various factors, and low immune function is considered to be one of the important reasons for the disease. In the prior art, the research on the treatment of children with exogenous fever is roughly (1) physical cooling, such as warm water or alcohol scrub bath, ice pack cooling, saline enema, etc.; (2) drug cooling, such as oral antipyretics, analgin Intranasal or intramuscular injection, intravenous infusion of dexamethasone and other drugs, while taking antibiotics to treat infection; (3) Chinese medicine therapy: such as oral Chines...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/192A61K36/9066A61P11/00A61P31/12A61P29/00A61P37/04
Inventor 林凡友林凡儒
Owner 仁和堂药业有限公司
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