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Medical adhesive and preparation method thereof

A technology of adhesives and tackifiers, applied in the fields of application, medical science, surgical adhesives, etc., can solve the problems that limit the application of α-cyanoacrylate adhesives, affect the aesthetics of the bonding surface, etc., and achieve good biocompatibility , no toxic side effects, easy to spread the effect

Active Publication Date: 2015-04-22
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The whitening phenomenon seriously affects the aesthetics of the bonding surface and largely limits the application of α‐cyanoacrylate adhesives in surgical operations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Formula: 80g of α‐octyl cyanoacrylate, 10g of plasticizer (dibutyl phthalate and dioctyl phthalate are prepared in 20:70 by weight), 8g of polymethyl methacrylate, p-toluene Sulfonic acid 2g, hydroquinone 0.1g.

[0028] The preparation method is as follows: add α-octyl cyanoacrylate, plasticizer and polymethyl methacrylate into a three-necked flask in sequence, mix and stir at 40°C for 1 hour, then add p-toluenesulfonic acid and hydroquinone Add to the three-necked flask, mix and stir evenly.

[0029] Performance Testing:

[0030] 1. Film formation time: Add 50ml of 0.3g / L sodium bicarbonate (prepared now) to a plate with a diameter of 90mm, absorb medical glue with a straw, drop a drop at a distance of 5cm from the liquid surface, and record the film formation time on the liquid surface .

[0031] Test results: The film forming time is 10s.

[0032] 2. Adhesive strength: Pigskin is selected as the test leather, with a thickness of 1‐2mm and a size of 10mm×50mm. Th...

Embodiment 2

[0037] Formula: 85g of α-octyl cyanoacrylate, 8g of plasticizer (dibutyl phthalate and dioctyl phthalate are prepared at 25:75 by weight), 6g of polymethyl methacrylate, p-toluene Sulfonic acid 1g, hydroquinone 0.07g.

[0038] The preparation method is as follows: add α-octyl cyanoacrylate, plasticizer and polymethyl methacrylate into a three-necked flask in sequence, mix and stir for 0.5h at 45°C, then add p-toluenesulfonic acid and terephthalic acid Phenol was added into the three-necked flask, mixed and stirred evenly.

[0039] Performance Testing:

[0040] 1. Film formation time: Add 50ml of 0.3g / L sodium bicarbonate (prepared now) to a plate with a diameter of 90mm, absorb medical glue with a straw, drop a drop at a distance of 5cm from the liquid surface, and record the film formation time on the liquid surface .

[0041] Test results: The film forming time is 10s.

[0042] 2. Adhesive strength: Pigskin is selected as the test leather, with a thickness of 1‐2mm and ...

Embodiment 3

[0047] Formula: 90g of α-octyl cyanoacrylate, 5.5g of plasticizer (dibutyl phthalate and dioctyl phthalate are prepared at 30:80 by weight), 4g of polymethyl methacrylate, Toluenesulfonic acid 0.5g, hydroquinone 0.05g.

[0048] The preparation method is as follows: add octyl α-cyanoacrylate, plasticizer and polymethyl methacrylate into a three-necked flask in sequence, mix and stir at 35°C for 1.5h, then add p-toluenesulfonic acid and terephthalic acid Phenol was added into the three-necked flask, mixed and stirred evenly.

[0049] Performance Testing:

[0050] 1. Film formation time: Add 50ml of 0.3g / L sodium bicarbonate (prepared now) to a plate with a diameter of 90mm, absorb medical glue with a straw, drop a drop at a distance of 5cm from the liquid surface, and record the film formation time on the liquid surface .

[0051] Test results: The film forming time is 8s.

[0052] 2. Adhesive strength: Pigskin is selected as the test leather, with a thickness of 1‐2mm and ...

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Abstract

The invention discloses a medical adhesive and a preparation method thereof. The medical adhesive comprises the following raw materials in parts by weight: 80-90 parts of alpha-cyanoacrylate, 5.5-10 parts of plasticizer, 4-8 parts of tackifier, 0.5-2 parts of stabilizer and 0.05-0.1 part of polymerization inhibitor, wherein the plasticizer is prepared by mixing dibutyl phthalate and dioctyl phthalate in a ratio of parts by weight of (20-30):(70-80), the tackifier is polymethyl methacrylate, the stabilizer is p-toluenesulfonic acid, and the polymerization inhibitor is hydroquinone. The medical adhesive provided by the invention has the advantages that the medical adhesive is convenient to use, is quickly cured, has high bonding strength, low heat release during bonding and low skin irritation, does not have toxic or side effects on human bodies and avoids whitening.

Description

technical field [0001] The invention relates to an adhesive patch, in particular to a medical adhesive and a preparation method thereof, belonging to the field of chemical and Chinese medical materials. Background technique [0002] At present, in medicine, suture is still the main operation method for tissue reconstruction, but some parts are difficult to suture, coupled with traditional surgical suture and hemostasis of organ tissue, not only time-consuming operation, replacement materials are required for repair, and additional surgery and tissue repair, and there are tissue inflammatory reactions, infection, hyperplasia, rupture, and even tissue and organ damage and non-absorption and other harmful effects. If the traditional suture can be replaced with adhesive, it will be a revolution in surgery. [0003] In 1955, the United States invented Eastman910 adhesive, that is, methyl α-cyanoacrylate, because it can quickly polymerize and solidify in the presence of water, an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/06C08L33/12
Inventor 袁文辉夏自龙李莉
Owner SOUTH CHINA UNIV OF TECH
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