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Metabolizable anti-blocking hemostatic membrane and preparation method thereof

A hemostatic film and anti-adhesion technology, which is used in medical science, textiles and papermaking, bandages, etc., can solve problems such as sensitization, and achieve the effects of increasing specific surface area, enhancing practicability and quality controllability

Inactive Publication Date: 2013-12-11
AILEYI MEDICINE MATERIAL SCI & TECH TIANJIN CITY
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0005] Compared with starch, dextran, etc., which naturally exist in animal origin, there is a potential risk of sensitization

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0018] The present invention will be further described below in conjunction with specific embodiments.

[0019] Example 1

[0020] Dissolve 5 g of dextran with a relative molecular mass of 40,000 in a 100 ml NaOH solution with a pH of 12, and configure a solution with a mass fraction of 5% as a spinning solution for use. Inject the above-mentioned spinning solution into a 50ml syringe with a flat needle with an inner diameter of 0.8 mm, fix the syringe on the micro syringe pump, and place a grounded metal drum receiving device 15 cm from the needle. Connect the needle with a 10KV high voltage direct current power supply, set the solution flow rate to 0.02ml / h for electrostatic spinning. The collected ultrafine fiber membranes were taken off and vacuum dried at 50°C and a vacuum degree of 200 Pa for 24 hours. The above-mentioned electrospun membrane is immersed in 50ml of 10% epichlorohydrin ethanol solution, and cross-linked at 55°C for 5h to obtain cross-linked polysaccharide fi...

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Abstract

The invention relates to a metabolizable anti-blocking hemostatic membrane and a preparation method thereof. The hemostatic membrane is prepared by adopting the preparation method comprising the following steps: fully mixing polysaccharide with a crosslinking agent according to a certain proportion, preparing the mixed solution to a fiber membrane through an electrostatic spinning technology, standing the fiber membrane in a constant temperature reaction box at a certain reaction temperature, and preparing a hemostatic fiber membrane through a crosslinking reaction. When being applied in a hemostasis process, the fiber membrane can directly block the hemorrhagic spot, a formed gel-shaped film can isolate air from the hemorrhagic spot to achieve an antibacterial effect, thereby being especially suitable for burn wound surfaces to avoid secondary injury of the wound surfaces, and meanwhile, the main ingredient of the fiber membrane is crosslinked polysaccharide which can be degraded in vivo within a certain period, so that the fiber membrane plays an anti-blocking function when being used for hemostasis in surgical operations.

Description

Technical field [0001] The invention belongs to the technical field of medical device production, and relates to a metabolizable anti-adhesion hemostatic membrane and a preparation method thereof. Background technique [0002] Electrospinning technology to prepare nanofiber materials is one of the most important academic and technical activities in the field of material science and technology in the world in the past ten years. Electrospinning has simple manufacturing equipment, low spinning costs, a wide variety of spinnable materials, and processes. Controllable and other advantages have become one of the main ways to effectively prepare nanofiber materials. Electrospinning technology has produced a rich variety of nanofibers, including organic, organic / inorganic composite and inorganic nanofibers. Electrospinning nanofibers have high specific surface area and porosity, and the formed fiber membrane has certain toughness and diversified uses, which makes the application of ele...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42D04H1/728
Inventor 郭雅楠
Owner AILEYI MEDICINE MATERIAL SCI & TECH TIANJIN CITY
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