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Drug composition for treating vomiting during pregnancy

A composition and drug technology, applied in the field of medicine, can solve the problem of too many pharmaceutical excipients, achieve large-scale production, facilitate absorption, and simple preparation process

Inactive Publication Date: 2013-12-11
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the above-mentioned invention, although the corresponding faster dissolution rate in the phosphate buffer solution of pH 6.8 has been achieved, the pharmaceutical excipients used are more

Method used

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  • Drug composition for treating vomiting during pregnancy
  • Drug composition for treating vomiting during pregnancy
  • Drug composition for treating vomiting during pregnancy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013]

[0014] Preparation:

[0015] (1) Pass doxylamine succinate through an 80-mesh sieve and set aside;

[0016] (2) Weigh the prescribed amount of microcrystalline cellulose (PH101) and lactose and mix them evenly;

[0017] (3) Water-made soft material, granulated with 24 mesh, dried at 60°C, and granulated with 40 mesh;

[0018] (4) Add the prescribed amount of magnesium stearate and colloidal silicon dioxide, and mix well;

[0019] (5) Intermediate detection and content determination.

[0020] (6) Calculate the tablet weight based on the content of the semi-finished product, adjust the tablet weight and pressure and then press the tablet.

Embodiment 2

[0022] prescription:

[0023]

[0024] Preparation:

[0025] (1) Pass doxylamine succinate and pyridoxine hydrochloride through an 80-mesh sieve and set aside;

[0026] (2) Weigh the prescribed amount of microcrystalline cellulose (PH102), pregelatinized starch, crospovidone, colloidal silicon dioxide, magnesium stearate and the main drug, and mix them evenly;

[0027] (3) The powder is directly pressed into tablets, acquired;

[0028] Because pyridoxine hydrochloride is easy to decompose when exposed to light, and the main part of the human body is the jejunum, the obtained plain tablets are coated with an enteric coating solution to ensure the safety of the medicine for long-term storage and avoid the destruction of gastric acid.

[0029] Coating liquid formula:

[0030]

[0031] (1) Take the prescribed amount of coating powder, slowly add it to the 50% ethanol solution under constant stirring, continue to stir for about 45-60 minutes, and set aside.

[0032] (2) Put the plain tablets in...

Embodiment 3

[0034] Since the solvent used in the coating liquid is absolute ethanol, considering that the pharmaceutical composition is mainly used for pregnant women, other enteric coating liquids are used instead.

[0035] prescription:

[0036]

[0037] Coating liquid formula:

[0038]

[0039]

[0040] (1) Take the prescribed amount of coating powder, slowly add it to the 50% ethanol solution under constant stirring, continue to stir for about 45-60 minutes, and set aside.

[0041] (2) Put the plain tablets in the coating pan, turn on the exhaust and dust collection device, heat to 40℃, turn on the coating pan, blow off the surface fine powder of the plain tablets, and preheat the plain tablets. Turn on the air compressor, adjust the speed of spraying liquid and air pressure, so that the coating liquid is sprayed in a mist form and sprayed onto the surface of the plain sheet. Continue spraying until the coating requirements are met, and continue hot air drying for 10 minutes. The coating we...

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Abstract

A drug composition for treating vomiting during pregnancy is formed by compositing doxylamine succinate or a composition of doxylamine succinate and pyridoxine hydrochloride as an active ingredient, and pharmaceutically acceptable auxiliary materials. The drug composition can be prepared into an oral preparation, including a tablet, a capsule and the like, by a certain preparation technology. The drug composition is used for treating women who have nausea and vomiting during the pregnancy and poor response to conservative treatment.

Description

Technical field [0001] The present invention is a novel medicine for treating morning sickness and its composition with pyridoxine hydrochloride, and belongs to the technical field of medicine. Background technique [0002] Morning sickness is a natural reaction during pregnancy. The main symptoms are weakness, depressed mood, dizziness, nausea, nausea, poor appetite, and sensitive or strong reaction to peculiar smell, especially in the early morning or when you just wake up. These symptoms generally occur around the fifth week of pregnancy. After the sixteenth week, most people's morning sickness will gradually decrease until it disappears naturally, but there are also a few pregnant women who have morning sickness throughout their pregnancy, which is more painful. Morning sickness is not only not conducive to the recovery of pregnant women, but also because most people's appetite is affected during pregnancy, and the fetus's nutrition comes from the mother. Therefore, how to de...

Claims

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Application Information

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IPC IPC(8): A61K31/4415A61P1/08A61K31/4402
Inventor 不公告发明人
Owner FUKANGREN BIO PHARMA
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