Compound gel for treating glaucoma and preparation method thereof

A compound, glaucoma technology, applied in the field of medicine, can solve problems such as large irritation, large side effects, and poor compliance, and achieve the effects of improving compliance, improving bioavailability, and prolonging residence time

Active Publication Date: 2013-12-11
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the above situation, in order to solve the defects of the prior art, the object of the present invention is to provide a compound gel for treating glaucoma and its preparation method, which can effectively solve the problem of large side effects, poor compliance and low bioavailability in the prior art. , stimulating questions

Method used

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  • Compound gel for treating glaucoma and preparation method thereof
  • Compound gel for treating glaucoma and preparation method thereof
  • Compound gel for treating glaucoma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] The gel is calculated by the following weight percentages: brinzolamide-resin complex 1%-2%, gel base 10%-20%, suspending agent 0.1%-10%, preservative 0.001%-0.009% , 0.1%-5% osmotic pressure regulator, 0.1-5% pH regulator and 51%-70% pharmaceutical water.

Embodiment 2

[0019] The gel is calculated by the following weight percentages: brinzolamide-resin complex 3%-4%, gel base 21%-40%, suspending agent 11%-20%, preservative 0.01%-0.02% , 6%-10% osmotic pressure regulator, 6-10% pH regulator and 30%-50% pharmaceutical water.

Embodiment 3

[0021] The gel is calculated by the following weight percentage: brinzolamide-resin complex 1%, poloxamer 40710%, carbomer 934P10%, sorbitol 6%, maltitol 4%, benzalkonium bromide 0.01 %, 3% sodium chloride, 3% potassium chloride, 2% sodium carbonate, 2% potassium phosphate and 58.99% pharmaceutical water.

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Abstract

The invention relates to compound gel for treating glaucoma and a preparation method thereof, effectively solving the problems of serious side effect, poor compliance, low bioavailability and serious irritation in the prior art. According to the technical scheme, the gel comprises the following components in percentage by weight: 1.0-4.0 percent of brinzolamide-resin compound, 10-40 percent of gel substrate, 0.1-20 percent of suspending agent, 0.001-0.02 percent of preservative, 0.1-10 percent of osmotic pressure regulator, 0.1-10 percent of pH regulator, and 30-70 percent of pharmaceutical water solution. The compound gel overcomes the defects that cream makes vision unclear and the dose of traditional gel is hard to control, is capable of prolonging the staying time of medicine on the surface of cornea, improving the bioavailability of the medicine in eyes and increasing the compliance of patients, and is an innovation in the field of medicine for treating glaucoma.

Description

technical field [0001] The invention relates to medicine, in particular to a composite gel for treating glaucoma and a preparation method thereof. Background technique [0002] Glaucoma is a common and difficult eye disease with rapid onset, great harm, and blindness at any time. The characteristic is that the intermittent or persistent increase in intraocular pressure exceeds the tolerance of the eyeball, causing damage to various parts of the eyeball and visual function, leading to optic atrophy, narrowing of the field of vision, and loss of vision. It is the main cause of blindness. One of the eye diseases. According to the figures released by the World Health Organization in 2005, glaucoma is the second leading cause of blindness in the world, second only to cataract, and the first irreversible cause of blindness in the world. There are 70 million glaucoma patients worldwide, and it is estimated that the number will reach 80 million by 2020. Global blindness caused by...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/542A61K47/48A61P27/06
Inventor 刘伟辛红霞刘华李晶李恒曾莉
Owner ZHENGZHOU UNIV
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