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A whitening agent liposome-coated microcapsule composition and its preparation method and application

A liposome and composition technology, applied in the field of whitening agent liposome-coated microcapsule composition and its preparation, can solve the problems of easy oxidative discoloration, vitamin C unfavorable skin absorption, difficult skin absorption, etc., to achieve long-term maintenance Time, overcome the easy to be oxidized and discolored, and maintain the effect of whitening effect

Active Publication Date: 2015-12-02
GUANGDONG IND TECHN COLLEGE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These whitening agents all have good whitening effects, but these whitening agents all have defects such as being easily oxidized by oxygen in the air and discolored and difficult to be absorbed by the skin. For example, vitamin C is not conducive to skin absorption, and is easily oxidized and discolored when exposed to heat and light. and lose the whitening effect

Method used

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  • A whitening agent liposome-coated microcapsule composition and its preparation method and application
  • A whitening agent liposome-coated microcapsule composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Preparation of whitening agent liposome-coated microcapsule composition (I)

[0027] (1) Mix 5% vitamin C, 8% ferulic acid, 5% glabridin, 10% 1,2-propanediol, 8% 1,3-butanediol, and 31% deionized water at 60-80 Stir and dissolve evenly at ℃, it is the water phase.

[0028] (2) Mix 15% isopropyl palmitate, 10% caprylic / capric triglyceride, 6% soybean lecithin, and 2% glycerol monostearate, stir and dissolve evenly at 60-80°C to form oil Mutually.

[0029] (3) Mix the water phase with the oil phase, stir evenly, and then process it through a high-pressure homogenizer. The pressure of the high-pressure homogenizer is 90 MPa, and the number of cycles is 4 times to obtain the whitening agent liposome-coated microcapsule combination of the present invention. Object (Ⅰ).

Embodiment 2

[0030] Example 2 Preparation of whitening agent liposome-coated microcapsule composition (II)

[0031] (1) Mix 6% kojic acid, 6% arbutin, 4% nicotinamide, 15% glycerin, 6% 1,3-butanediol, and 30% deionized water, stir and dissolve evenly at 60-80°C , is the water phase.

[0032] (2) Mix 6% tocopheryl acetate, 12% caprylic / capric triglyceride, 8% tea seed oil, 4% soybean lecithin, 3% methyl glucose sesquistearate at 60 Stir and dissolve evenly at -80°C, forming an oil phase.

[0033] (3) Mix the water phase with the oil phase, stir evenly, and process it through a high-pressure homogenizer. The pressure of the high-pressure homogenizer is 100 MPa, and the number of cycles is 3 times, and the whitening agent liposome-coated microcapsule combination of the present invention is obtained. Object (Ⅱ).

Embodiment 3

[0034] The preparation of embodiment 3 whitening skin care milk

[0035] Table 1 shows the whitening skin care milk formula containing the liposome-coated microcapsule composition of the whitening agent, and the consumption of each substance is expressed by mass fraction.

[0036] Table 1

[0037]

[0038] The preparation method of whitening skin care milk: Dimethicone, isopropyl palmitate, caprylic acid / capric glyceride, monoglyceride, glyceryl oleate citrate, methylparaben, Mix propylparaben, heat to 80°C, melt and stir evenly, and use it as the oil phase; mix 1,3-butanediol and deionized water in the formula table, heat to 85°C, stir and dissolve evenly, and use it as the water phase . Add the oil phase and the water phase to the emulsification pot, stir evenly, add the whitening agent liposome-coated microcapsule composition, emulsify and homogenize for 10 minutes, stir and cool to 50°C, add essence, stir evenly, and cool to 38 ℃, that is, whitening skin care milk. ...

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Abstract

The invention discloses a whitening agent liposome-coated microcapsule composition, a preparation method and application thereof. The whitening agent liposome-coated microcapsule composition of the present invention consists of 5-30% whitening agent, 2-50% polyol, 1-30% phospholipid, 1-30% oil, 1-10% emulsifier, deionized Water 1-30% composition. The whitening agent of the present invention is coated by lecithin, and the lecithin is very similar to the lipid structure of the skin, and is easy to penetrate into the deep layer of the skin, thereby overcoming the defect that the whitening agent is difficult to be absorbed by the skin; the whitening agent coated by lecithin and The oxygen in the air is isolated, thereby overcoming the defect that these whitening agents are easily oxidized and discolored; when using the whitening product containing the whitening agent liposome-coated microcapsule composition of the present invention, the whitening agent is released slowly and can maintain long-term whitening effect.

Description

technical field [0001] The invention relates to a whitening agent liposome-coated microcapsule composition, in particular to a whitening agent liposome-coated microcapsule composition and a preparation method and application thereof. Background technique [0002] The color of human skin is mainly determined by the content and distribution of melanin in the skin. Melanin is produced by melanocytes present in the basal layer of the epidermis, and its metabolism is regulated by internal neuroendocrine factors and influenced by the external environment. For example, when the skin is irradiated by external ultraviolet rays, it will activate the tyrosinase in the skin, accelerate the production of melanin, and cause tanning and pigmentation reactions. The role of whitening active ingredients in whitening cosmetics is to prevent the biosynthesis of melanin, or by activating the ability of human epidermal and dermal cells to resist free radicals, promote the metabolic renewal of ep...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/14A61K8/11A61K8/55A61K8/92A61K8/37A61K8/894A61K8/60A61K8/67A61K8/49A61K8/36A61K8/34A61Q19/02
Inventor 龚盛昭
Owner GUANGDONG IND TECHN COLLEGE
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