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A Chinese medicinal compound targeting lipid nanosphere composition and preparation method thereof

A technology of lipid nanospheres and targeting lipids, which can be used in pharmaceutical formulations, liposome delivery, cosmetic preparations, etc. It can solve the problems that have not been seen in the application of tanshinone IIA, and achieve long-term whitening effect and not easy to oxidize , the effect of reducing the amount of use

Active Publication Date: 2019-08-13
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there is no relevant report on the application of Tanshinone IIA in whitening

Method used

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  • A Chinese medicinal compound targeting lipid nanosphere composition and preparation method thereof
  • A Chinese medicinal compound targeting lipid nanosphere composition and preparation method thereof
  • A Chinese medicinal compound targeting lipid nanosphere composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method for targeting lipid nanospheres of Chinese medicinal compounds, comprising the steps of:

[0031] Composition formula

[0032] weight Glyceryl Tristearate 3.8g diglyceride behenate 2.7g Soybean oil 3.5g Soy Lecithin 7.1g Tween 80 7.9 Transferrin 12.5mg Octreotide 12.5mg Tanshinone IIA 5g Deionized water 70g Crosslinker N-Hydroxysuccinimide-3–(2-pyridinedithio)propionate 25mg

[0033] The preparation steps of this embodiment are as follows:

[0034] 1. Weigh 3.8g of glyceryl tristearate, 2.7g of diglyceride behenate, 3.5g of soybean oil into a 150ml beaker, then add 5g of tanshinone IIA, 7.1g of soybean lecithin, 7.9g Tween 80, heat up to 60°C to make oil phase.

[0035] 2. Add the above oil phase into 70g of deionized water, and stir at 60°C for 10,000r until uniform.

[0036] 3. After stirring evenly, it is processed by a high-pressure homogenizer. The pressure of the...

Embodiment 2

[0039] Composition formula

[0040] weight glyceryl laurate 3.9g stearyl alcohol 2.5g Octadecylamine 4.6g polyethylene glycol 400 22g Sodium dodecyl sulfonate 23g Octreotide 25mg RGD polypeptide 25mg Tanshinone IIA 9g Deionized water 35g Crosslinker N-Hydroxysuccinimide-3–(2-pyridinedithio)propionate 50mg

[0041] The preparation steps of this embodiment are as follows:

[0042] 1. Weigh 3.9g of glyceryl laurate, 2.5g of stearyl alcohol, and 4.6g of stearylamine into a 150ml beaker, then add 9g of tanshinone IIA, 22g of polyethylene glycol 400, and 23g of dodecanoic acid sulfonate Sodium acid, heated to 65 ° C to make the oil phase.

[0043] 2. Add the above oil phase into 35g of deionized water, and stir evenly at 65°C at 15000r at a high speed.

[0044] 3. After stirring evenly, it is processed by a high-pressure homogenizer. The pressure of the high-pressure homogenizer is 110Mpa, and the numbe...

Embodiment 3

[0047] Composition formula

[0048]

[0049]

[0050] The preparation steps of this embodiment are as follows:

[0051] 1. Weigh 15.7g of isopropyl palmitate and 29.3g of behenic acid monoglyceride into a 150ml beaker, then add 5g of tanshinone IIA, 5.5g of polyethylene glycol 400, 6.5g of egg yolk lecithin, 3g Tween 80, heated to 72°C to make the oil phase.

[0052] 2. Add the above oil phase into 35g of deionized water, and stir at a high speed of 14000r at 72°C to make it even.

[0053] 3. After stirring evenly, it is processed by a high-pressure homogenizer. The pressure of the high-pressure homogenizer is 100Mpa, and the number of cycles is 12.

[0054] 4. Use 70mg of N-hydroxysuccinimide-3-(2-pyridyldithio)propionate (SPDP) as a cross-linking agent to prepare lipid nanospheres, and connect 35mg of octreotide and 35mg of C16Y polypeptide to the lipid On the nanosphere, promptly obtained the lipid nanosphere that comprises traditional Chinese medicine compound; Me...

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Abstract

The invention discloses a traditional-Chinese-medicine-compound-targeting lipid nanosphere composite and a preparing method thereof. The composition is prepared from, by weight, 5-15 parts of tanshinone IIA, 10-45 parts of a lipid material, 15-45 parts of an emulsifying agent, 0.00025-0.001 part of modification protein, 35-70 parts of deionized water and 0.00025-0.001 part of a cross-linking agent N-hydroxysuccinimidyl-3-(2-pyridyldithio)propionate. According to the traditional-Chinese-medicine-compound-targeting lipid nanosphere composite and the preparing method, a traditional Chinese medicine compound is wrapped by lipid nanospheres; as the particle size of the lipid nanospheres is small, skin permeation is easy, safety is high, skin stimulation is reduced, forming of melanin of targeted melanocytes can be more easily reduced after protein or polypeptide modification, and the skin whitening effect is achieved.

Description

technical field [0001] The invention relates to the technical field of cosmetics and preparation of lipid nanospheres, in particular to a Chinese medicine compound-targeted lipid nanosphere composition with whitening effect and a preparation method thereof. Background technique [0002] Having fair skin is the dream of every woman, so whitening has become a never-fading fashion topic for women and cosmetics formulation designers. Human skin color is largely determined by the production and distribution of melanin in the body, and the function and quantity of melanocytes directly affect the content of melanin in the skin, which is an important factor in making the skin fair or not. Melanin exists in the middle of the cells in the basal layer of the skin. When ultraviolet rays irradiate the skin, the activity of tyrosinase will be activated, and tyrosinase will react with tyrosine in the blood to produce a substance called dopa. Dopa is actually the predecessor of melanin, wh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/127A61K8/14A61K8/63A61K8/64A61Q19/02
CPCA61K8/14A61K8/342A61K8/361A61K8/37A61K8/375A61K8/41A61K8/63A61K8/64A61K8/922A61Q19/02
Inventor 彭丽华黄燕芬
Owner ZHEJIANG UNIV
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