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Extraction process of acetylisovaleryltylosin

A technology of Tylos acetylisovaleryl and Tylos acetylisovaleryl, which is applied in the chemical field and can solve problems such as emulsification and low yield

Active Publication Date: 2013-11-27
宁夏泰瑞制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The yield of this extraction method is low, because one-time adjustment of pH value and plate-and-frame filtration can only remove part of the protein, and the Tylos acetylisovaleryl fermentation broth still contains a large amount of protein, which will be used in subsequent pros and cons. Emulsification will occur during extraction, resulting in low yield

Method used

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Embodiment Construction

[0015] The present invention will be described in further detail below through specific examples.

[0016] Embodiments of the present invention provide a kind of Tylos acetylisovaleryl extraction process, comprising:

[0017] Pretreatment of Tylos acetylisovaleryl fermentation broth to remove amino acid proteins with isoelectric points at 4-4.5 and 2-2.5;

[0018] performing scraper-type filtration on the pretreated Tylos acetylisovaleryl fermentation liquid, and collecting the first filtrate;

[0019] performing membrane filtration on the first filtrate at a temperature of 30-40° C., and collecting the second filtrate;

[0020] At a temperature of 25-30°C, nanofiltration is performed on the second filtrate, and the third filtrate is collected;

[0021] When the pH value is 10-11 and the temperature is 10-15°C, solid acetylisovaleryl tylosin crystals are precipitated from the third filtrate, and the precipitated acetylisovaleryl tylosin crystals are cultured for solid-liquid...

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PUM

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Abstract

The invention relates to the field of chemistry, and particularly relates to an extraction process of acetylisovaleryltylosin. The method comprises the following steps: pretreating an acetylisovaleryltylosin fermentation liquid to remove amino acid proteins with the isoelectric points of 4-4.5 and 2-2.5; carrying out scraper filtration, and collecting a first filtrate; carrying out membrane filtration at 30-40 DEG C, and collecting a second filtrate; carrying out nanofiltration at 25-30 DEG C, and collecting a third filtrate; precipitating a solid acetylisovaleryltylosin crystal from the third filtrate at 10-15 DEG C, culturing, and carrying out solid-liquid separation to obtain solid acetylisovaleryltylosin; washing with water repeatedly; reacting the washed acetylisovaleryltylosin and tartaric acid to obtain an acetylisovaleryltylosin tartrate solution; and carrying out spray drying to obtain acetylisovaleryltylosin tartrate powder. The invention can avoid using the traditional extraction method using organic solvent and butyl acetate, and has the advantage of higher yield.

Description

technical field [0001] The invention relates to the field of chemistry, in particular to an extraction process of Tylos acetylisovaleryl. Background technique [0002] Tylos acetylisovaleryl is a weak base and can form salts with tartaric acid, etc. Tylos acetylisovaleryl has a high solubility in butyl acetate, so the relevant extraction method is: first pretreat the fermentation broth of Tylos acetylisovaleryl, the pretreatment includes: The pH value of the Tylosia fermented liquid was adjusted at one time, and the plate and frame filtration was carried out; then, the pretreated Tylos acetylisovaleryl fermented liquid was subjected to forward and reverse extraction according to water-butyl acetate (AIV was transferred from the aqueous phase to the acetic acid The butyl phase is forward extraction, and the AIV transfer from butyl acetate phase to water phase is back extraction). The aqueous solution of the AIV salt obtained by back extraction can be spray-dried after refin...

Claims

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Application Information

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IPC IPC(8): C07H17/08C07H1/06
Inventor 任勇
Owner 宁夏泰瑞制药股份有限公司
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