Dentifrice Composition

Abstract

Provided are a dentifrice composition which comprises ascorbic acid phosphate ester or a salt thereof having outstanding stability, has a good feel when used, and has decreased buccal irritation during use and after use, and a method for stabilizing ascorbic acid phosphate ester or a salt thereof in the dentifrice composition, wherein ascorbic acid phosphate ester or a salt thereof is maintained stable over time at a pH of 8.0 or less. The dentifrice composition contains (A) ascorbic acid phosphate ester or a salt thereof, and includes (B) a silica-based abrasive and (C) an alkali metal salt selected from sodium chloride, potassium chloride, sodium sulphate, and potassium sulphate, and the dentifrice composition has a pH at 25°C of 6.0-8.0. The method for stabilizing ascorbic acid phosphate ester or a salt thereof in the dentifrice composition comprises mixing constituent (B) and also constituent (C) in the dentifrice composition containing constituent (A), and making the pH at 25°C to be 6.0-8.0.

Description

technical field [0001] The present invention relates to a dentifrice composition which keeps ascorbyl phosphate or ascorbyl phosphate in a region of pH 8.0 or less, and a method for stabilizing ascorbyl phosphate or its salt in the dentifrice composition. The stability of the salt, the stability of ascorbyl phosphate or its salt is excellent, the irritation in the oral cavity during and after use is reduced, and the feeling of use is good. Background technique [0002] In recent years, ascorbyl phosphate or a salt thereof has been attracting attention as an antioxidant vitamin that eliminates excess reactive oxygen species produced in a living body and protects living tissue from oxidative damage. In addition, ascorbyl phosphate or salts thereof are known to have various physiological activities, and have preventive and therapeutic effects on gingivitis and periodontitis in the oral field, and attempts have been made to incorporate them into oral compositions such as toothpa...

AI Technical Summary

Problems solved by technology

[0006] However, there is such a problem that among the periodontal disease preventive ingredients, there are substances that cannot ensure stability over time under alkaline conditions (hereinafter referred to as "alkali-labile periodontal disease preventive ingredients"), such as tranexamic acid, The stability of ε-aminocaproic acid decreases over time at pH above 8.0

[0007] That is, when ascorbyl phosphate or its salt is to be mixed with the "alkali-labile periodontal disease prevention ingredient" in the dentifrice composition at the same time, if the combination is to ensure the stability of ascorbyl phosphate or its salt If the pH of the substance exceeds 8.0 at 25°C, the stability of the "alkali-labile periodontal disease prevention ingredient" will decrease over time. The stability of "preventive ingredients" cannot meet the high gingivitis prevention effect and the feeling of use at the same time.

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