Method for preparing nanometer bionic slow release biomedical dressing by electrostatic spinning

A nano-bionic and biomedical technology, applied in the field of biomedicine, can solve the problems of lack of effective, fast and convenient rescue drugs and methods, cumbersome analgesic and antibacterial operations, and restrictions on the application of dressings in the treatment of skin defect wounds, so as to achieve sustained release ability, good biocompatibility, and easy operation

Inactive Publication Date: 2013-11-20
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is a lack of effective, rapid and convenient treatment drugs and methods for the treatment of acute war wound skin defect wounds. The electronic bandages, biological bandages and other dressings developed abroad for the healing of war wounds are all due to the lack of effective wound healing, sedative Defects such as anti-pain and antibacterial and cumbersome operation restrict the application of these dressings in field first aid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Preparation of electrospinning precursor solution:

[0026] Adopt 0.1mol / l citric acid-sodium hydroxide-hydrochloric acid buffer solution to adjust the pH value of silk fibroin mother liquor to 6.9, adopt ultrapure water to carry out above-mentioned silk fibroin mother liquor, human epidermal growth factor, fibroblast growth factor The electrospinning precursor solution was prepared by mixing and dissolving, in which the mass percent concentration of silk fibroin was 20%, and the concentrations of human epidermal growth factor and fibroblast growth factor were 100ppm.

[0027] (2) Electrospinning with the electrospinning precursor solution to prepare a slow-release fiber membrane dressing with a micro-nano bionic structure:

[0028] The electrospinning solution was loaded into a syringe pump for electrospinning, wherein the syringe pump advance speed was 2ml / h, the inner diameter of the needle was 0.6mm, the external source voltage was 25kV, the distance between the...

Embodiment 2

[0030] (1) Preparation of electrospinning precursor solution:

[0031] Use 0.1mol / l citric acid-sodium hydroxide-hydrochloric acid buffer solution to adjust the pH value of the silk fibroin mother liquor to 6.0, and use ultrapure water to mix and dissolve the above silk fibroin mother liquor and fibroblast growth factor to prepare the electrospinning precursor Solution, wherein the mass percent concentration of silk fibroin is 25%, and the concentration of fibroblast growth factor is 200ppm.

[0032] (2) Electrospinning with the electrospinning precursor solution to prepare a nano-bionic slow-release fiber membrane dressing:

[0033] The electrospinning solution was loaded into a syringe pump for electrospinning, where the pump speed was 1.5ml / h, the inner diameter of the needle was 0.4mm, the external voltage was 16kV, the distance between the needle and the receiving plate was 14cm, and the room temperature was 25°C. After 30 min of spinning, the electrospinning was stopped...

Embodiment 3

[0035] (1) Preparation of electrospinning precursor solution:

[0036] Chitosan, human epidermal growth factor, and fibroblast growth factor were mixed and dissolved in ultrapure water to prepare an electrospinning precursor solution, wherein the mass percent concentration of chitosan was 3%, and the concentration of fibroblast growth factor was 200ppm .

[0037] (2) Electrospinning with the electrospinning precursor solution to prepare a nano-bionic slow-release fiber membrane dressing:

[0038] The electrospinning solution was loaded into a syringe pump for electrospinning, where the pump speed was 2.8ml / h, the inner diameter of the needle was 0.3mm, the external voltage was 19kV, the distance between the needle and the receiving plate was 20cm, and the room temperature was 24°C. After 30 min of spinning, the electrospinning was stopped.

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Abstract

The invention provides a nanometer bionic slow release biomedical dressing and a preparation method thereof. The nanometer bionic slow release fibrous membrane dressing is applied to providing a good microenvironment to union of wounds and promoting hemostasis, analgesia and antibiosis. The stoste of the nanometer bionic slow release biomedical dressing is aqueous liquor containing silk fibroin, human epidermal growth factors and fibroblast growth factors, and the pH value is 5-8, wherein the mass percentage concentration of silk fibroin is 2-30% and total concentration of the human epidermal growth factors and the fibroblast growth factors is 0-200ppm; or chitosan with the mass percentage concentration of 1-10% replaces the silk fibroin; the electrostatic spinning technology is adopted, so that the stoste of the nanometer bionic slow release biomedical dressing forms a spraying jet which is sprayed to a collector so as to obtain the nanometer bionic slow release biomedical dressing.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a nano-bionic slow-release fibrous membrane dressing for promoting skin tissue repair and a preparation method thereof. Background technique [0002] The high-tech of modern warfare has made the injury mechanism of war injuries more complex, more serious tissue damage, high infection rate, slow wound healing, and susceptibility to the injury environment. As a medical dressing used in the physiological environment of the human body, the raw materials used in the preparation of the dressing must have excellent biocompatibility, non-toxicity, and even degradability. With the rapid development of nano-micro-materials, non-toxic, degradable, good film-forming and biocompatible natural polymer materials have received extensive attention in wound repair and artificial skin applications. Natural polymers currently used in the biomedical field mainly include polysaccharid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/44D01D5/00
Inventor 李学拥李跃军蒋立李靖邓晨
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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