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Asia 1 type foot and mouth disease virus antigen and preparation and application thereof

A technology of foot-and-mouth disease virus and antigen, which is applied in the fields of application, antiviral agent, botany equipment and method, etc., can solve the problems of limitation and toxicity application, and achieve good immunogenicity effect

Active Publication Date: 2015-06-24
LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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  • Abstract
  • Description
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Problems solved by technology

In addition, studies have shown that E. coli heat-sensitive enterotoxin ( LT ) has proven to be a potent adjuvant for mucosal immunity, but its application is limited due to its toxicity

Method used

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  • Asia 1 type foot and mouth disease virus antigen and preparation and application thereof
  • Asia 1 type foot and mouth disease virus antigen and preparation and application thereof
  • Asia 1 type foot and mouth disease virus antigen and preparation and application thereof

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Embodiment Construction

[0023] The preferred embodiments of the present invention will be described below in conjunction with the accompanying drawings. It should be understood that the preferred embodiments described here are only used to illustrate and explain the present invention, and are not intended to limit the present invention.

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Abstract

The invention discloses a nucleotide sequence opti-LTB-Asia 1 / VP1 and a recombinant vector pC 1300 / opti-LTB-Asia 1 / VP1 containing the sequence. The invention further discloses fusion expression mucosal immune adjuvant Asia 1 type foot and mouth disease virus antigen prepared by using the recombinant vector pC 1300 / opti-LTB-Asia 1 / VP1 and an application thereof. The antigen expressed by transgenic tomatoes has good immunogenicity. The transgenic tomatoes only express sigmasubunit antigen, do not contain pathogenic microorganisms or potential pathogenic microorganisms and are safe for human and livestock and free of pathogen pollution. An extraction and purification process is not required by producing immunogen through transgenic plants, and the antigen, the preparation and the application have the advantages of being simple in process, good in immune effect and protective effect on animals and the like and are suitable for immunity of livestock.

Description

technical field [0001] The invention relates to an antigen, in particular to the preparation and application of an Asia1 type foot-and-mouth disease virus antigen fused and expressed with a mucosal immune adjuvant. Background technique [0002] Foot-and-Mouth Disease (FMD) is an acute, febrile, highly contagious infectious disease caused by Foot-and-Mouth Disease Virus (FMDV), mainly infecting artiodactyls (Snowdon et al, 1968), although the fatality rate of the disease is not high, it causes the decline of animal production performance, and the outbreak of the disease affects international trade, often causing heavy direct and indirect economic losses. [0003] At present, the prevention and control of FMD mainly adopts the policy of combining immunization and culling (Aggarwal et al, 2002), and a safe and effective vaccine is a prerequisite for the successful prevention and elimination of FMD. Attenuated foot-and-mouth disease vaccine has better immunity, long duration of...

Claims

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Application Information

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IPC IPC(8): C12N15/62C12N15/84C07K19/00A61K39/39A61K39/135A61P31/14
Inventor 张永光潘丽王永录方玉珍吕建亮周鹏张中旺刘新生蒋守田
Owner LANZHOU INST OF VETERINARY SCI CHINESE ACAD OF AGRI SCI
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