Micro-nano fiber biosensor

A biosensor and micro-nano optical fiber technology, applied in the field of biosensors, can solve problems such as poor stability, complex structure, and low accuracy, and achieve the effects of stable structure, flexible operation, and simple system structure

Active Publication Date: 2013-09-25
HARBIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims to solve the problems of complex structure, poor stability and low accuracy of the existing real-time living body measurement equipment for the Brillouin spectrum of living organisms, thereby providing a micro-nano optical fiber biosensor

Method used

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Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0018] Specific implementation mode 1. Combination Figure 1 to Figure 3 Describe this specific embodiment, a micro-nano optical fiber biosensor, which includes a laser 1, a coupler 2, a microwave source 3, a single-sideband modulator 4, a polarization scrambler 5, a liquid storage device 6, a micro-nano optical fiber 7, a circular device 8, erbium-doped fiber amplifier 9, electro-optic modulator 10, function generator 11, photodetector 12, lock-in amplifier 13 and oscilloscope 14,

[0019] The liquid storage device 6 is filled with the solution to be tested; the micro-nano optical fiber 7 is located in the solution in the liquid storage device 6;

[0020] The laser light emitted by the laser 1 is incident on the coupler 2, and is divided into the first beam and the second beam by the coupler 2, and the first beam is incident on the SSB modulator 4, and the microwave source 3 drives the SSB modulator 4 pairs The No. 1 light beam is modulated to obtain probing light; the probi...

specific Embodiment approach 2

[0023] Embodiment 2. The difference between this embodiment and the micro-nano optical fiber biosensor described in Embodiment 1 is that the laser 1 is a narrow-linewidth single-frequency fiber laser.

specific Embodiment approach 3

[0024] Embodiment 3. The difference between this embodiment and the micro-nano optical fiber biosensor described in Embodiment 1 or 2 is that the coupler 2 is a 50:50 coupler.

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Abstract

Provided is a micro-nano fiber biosensor which relates to the optics field and concretely relates to a biosensor. The micro-nano fiber biosensor aims to solve problems of complex structure, poor stability and low accuracy of real-time in vivo measurement devices for Brillouin spectra of living bodies. Laser emitted from a laser device of the micro-nano fiber biosensor goes into a coupler, and is divided into a number one light beam and a number two light beam by the coupler. The number one light beam is modulated by a single-side band modulator, and goes into a number one light input end of a circulator. The intensity of the number two light beam is modulated by an electrooptical modulator. The number two light beam is amplified by an erbium-doped optical fiber amplifier and goes into a number two light input end of the circulator. Light emitted from a light output end of the circulator goes into a light-sensing end of a photoelectric detector. Electrical signals of the photoelectric detector are output to an oscilloscope by a lock-in amplifier. The micro-nano biosensor is suitable for real-time in vivo measurement for Brillouin spectra of living bodies.

Description

technical field [0001] The invention relates to the field of optics, in particular to a biological sensor. Background technique [0002] Spontaneous Brillouin scattering is an inelastic scattering process that originates from incoherent density fluctuations or phonons in a medium. The Brillouin spectrum reflects the spectral changes during the scattering process and directly gives the phonon information related to the elastic-optical properties of the medium. The sound velocity can be directly calculated from the Brillouin frequency shift, the elastic constant can be calculated from the sound velocity, and the information about the anisotropy of the sound velocity, the relaxation process and the phase transition can be obtained from the change of the sound velocity. From the Brillouin linewidth (requires a high-resolution device), the phonon attenuation process can be studied, and the viscosity characteristics of the material can be obtained. According to the measurement o...

Claims

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Application Information

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IPC IPC(8): G01N21/17
Inventor 张洪英张天安少楠解婉莹何健刘文擎
Owner HARBIN UNIV OF SCI & TECH
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