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Method for rapidly measuring p-hydroxy-benzoate ester in cosmetics

A hydroxybenzoate, rapid determination technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of low analysis efficiency, high analysis cost, high operation intensity, etc., and achieve high analysis efficiency, low analysis cost, The effect of low operating intensity

Inactive Publication Date: 2013-09-18
GUANGXI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The technical problem to be solved by the present invention is to provide a rapid determination method for parabens in cosmetics, so as to solve the shortcomings of low analysis efficiency, high operation intensity and high analysis cost in the prior art

Method used

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  • Method for rapidly measuring p-hydroxy-benzoate ester in cosmetics
  • Method for rapidly measuring p-hydroxy-benzoate ester in cosmetics
  • Method for rapidly measuring p-hydroxy-benzoate ester in cosmetics

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Embodiment 1

[0062] A rapid assay method for parabens in cosmetics, comprising the following steps:

[0063] A. Processing of samples to be tested:

[0064] Extract and filter the cosmetic sample to be tested with methanol. The specific operation is as follows: weigh 1.00 g of the sample into a stoppered test tube, add 10.0 mL of methanol to oscillate until dispersed, extract by ultrasonic wave for 15 min; rotate at 4000 rps, centrifuge for 10 min, take the supernatant and filter, A cosmetic filtrate was obtained.

[0065] B. Establishment of background spectrum database:

[0066] B1. Obtain spectral data of cosmetic samples:

[0067] The cosmetic filtrate prepared in step A is analyzed by high performance liquid chromatography, and multi-wavelength spectral data of multiple cosmetic samples are collected;

[0068] B2. Obtain the spectral data of the component to be measured:

[0069] Prepare a 10mg / L mixed methanol solution of methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, an...

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Abstract

The invention discloses a method for rapidly measuring a p-hydroxy-benzoate ester in cosmetics and relates to a method for measuring components in the cosmetics. The method comprises the following steps: A, treating a sample to be measured; B, establishing a background spectral database, namely B1, acquiring spectral data of a cosmetic sample; B2, acquiring spectral data of components to be measured; B3, converting the data format; B4, acquiring spectral data of a background which does not contain the components to be measured; B5, reducing the dimensionality of a background database; C, acquiring a standard spectral database v of the p-hydroxy-benzoate ester; D, measuring a spectrum of the cosmetic sample to be measured; E, measuring the content of the p-hydroxy-benzoate ester in the cosmetic sample to be measured. The method is high in analysis efficiency, low in operating strength and low in analysis cost, the background database which does not contain the measured components is not required to be accumulated, the machine hour and the reagent loss can be reduced, the robustness is high, and the method is simple and suitable for rapidly analyzing and measuring the same type of large-scale samples.

Description

technical field [0001] The invention relates to a method for determining components in cosmetics, in particular to a method for rapidly determining preservative parabens in cosmetics. Background technique [0002] Parabens, that is, parabens, are commonly used preservatives in cosmetics, and their analysis methods are mainly chromatographic methods, including thin-layer chromatography, gas chromatography, and high-performance liquid chromatography (HPLC). and capillary electrophoresis, etc. When gas chromatography is used to determine polar substances such as hydroxyl and carboxyl, it generally needs to undergo methyl silylation and derivatization before using gas chromatography for qualitative and quantitative analysis. Therefore, it is limited in the detection of preservatives; thin-layer chromatography The method can carry out the qualitative analysis of various components, does not require special equipment, and is easy to popularize; high performance liquid chromatogra...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 粟晖姚志湘方凤陈成刘柳
Owner GUANGXI UNIVERSITY OF TECHNOLOGY
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