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6-aryl amido hexyl hydroximic acid collecting agent and preparation and application methods thereof

A technology of ylhexyl hydroxamic acid and ylhexyl hydroxamic acid salt, which is applied in the field of 6-aryl amidohexyl hydroxamic acid collector and its preparation and application, and can solve the problems of amide bond breaking, easy hydrolysis, and acid chloride toxicity Large and other problems, to achieve the effect of strong chelation ability, short reaction time, and easy access to raw materials

Active Publication Date: 2015-05-20
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this method is that the acid chloride is highly toxic and easily hydrolyzed, and the hydroximation reaction needs to be reacted under the conditions of heating and strong alkali, which will easily cause the amide bond in the molecule to break.
[0009] The research on hydroxamic acid containing substituted arylamide groups in the molecule is limited to the biological activity of this type of compound to inhibit histone deacetylase, and this inhibitory activity is an effective way to treat cancer, and it is also a relatively recent research. A broad class of histone deacetylase (HDAC) inhibitors, while the use of 6-arylamide hydroxamic acids as flotation collectors in flotation has not been reported so far

Method used

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  • 6-aryl amido hexyl hydroximic acid collecting agent and preparation and application methods thereof
  • 6-aryl amido hexyl hydroximic acid collecting agent and preparation and application methods thereof
  • 6-aryl amido hexyl hydroximic acid collecting agent and preparation and application methods thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Add 11.32 parts of caprolactam with a purity of 99% and 6.95 parts of hydroxylamine hydrochloride with a purity of 99% into the reactor, add 34.64 parts of benzene or toluene as a solvent, heat to 80-110°C under stirring, react for 1-4 hours, and distill The solvent is recovered; then 12.21 parts of benzoic acid are added into the above-mentioned reactor, heated to 100-160° C. under stirring, and reacted for 4 hours to obtain the required 6-benzamide hexyl hydroxamic acid product. Liquid chromatography analysis shows that the purity of 6-benzamide hexyl hydroxamic acid is 95.3% (see figure 1 ), the yield was 92.4%. MS detected by mass spectrometry: 251.2 (see figure 2 ); Infrared spectrum see image 3 , 3025cm -1 It is N-H and O-H stretching vibration; 2934cm -1 It is saturated C-H stretching vibration; 1690cm -1 It is C=O stretching vibration; 1623cm -1 is the stretching vibration of a secondary amide; 1582cm -1 It is C-N bending vibration; 1452cm -1 C=C stret...

Embodiment 2

[0039] Embodiment 2: the application of 6-benzamide hexyl hydroxamic acid in tungsten ore flotation

[0040] A scheelite tailings containing WO 3 0.58%, grinding fineness -200 mesh accounted for 80%, using 1500g / t sodium carbonate to adjust pH value, 500g / t water glass as dispersant, after a rough separation operation, tungsten coarse concentrate was obtained. The flotation results of benzamide hexyl hydroxamic acid and benzyl hydroxamic acid are shown in Table 1. The results showed that 6-benzamide hexyl hydroxamic acid combined with oxidized paraffin soap 731, compared with benzyl hydroxamic acid, tungsten concentrate WO 3 The recovery rate increased by 2.60 percentage points.

[0041] Table 1 Flotation conditions and results of tungsten ore

[0042]

Embodiment 3

[0043] Example 3: Application of 6-benzamide hexyl hydroxamic acid in bauxite flotation

[0044] A bauxite containing Al 2 o 3 65.26%, SiO 2 10.43%, grinding fineness -200 mesh accounts for 80%, using 2500g / t of sodium carbonate to adjust the pH value, 50g / t of sodium hexametaphosphate, after a roughing operation, to obtain aluminum rough concentrate, 6-Benzene The flotation results of amidohexyl hydroxamic acid and oleic acid are shown in Table 2. The results showed that the combination of 6-benzamide hexyl hydroxamic acid and oleic acid, compared with benzyl hydroxamic acid, the aluminum concentrate Al 2 o 3 The recovery rate increased by 3.13 percentage points, and the aluminum-silicon ratio A / S increased by 0.44.

[0045] Table 2 Bauxite ore flotation conditions and results

[0046]

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Abstract

The invention discloses a 6-aryl amido hexyl hydroximic acid collecting agent and preparation and application methods thereof. 6-aryl amido hexyl hydroximic acid represented by a formula (I) is taken as a collecting agent and utilized in flotation of tungsten ore, tombarthite ore, tin ore or bauxite, wherein R represents H or C1-8 alkyl. 6-aryl amido hexyl hydroximic acid and sodium hydroxide, potassium hydroxide or ammonium hydroxide are put into water to prepare an aqueous solution of 6-aryl amido hexyl hydroxyoximate; a flotation reagent is added for size mixing during an ore grinding and / or flotation process, the added reagent at least contains the aqueous solution of 6-aryl amido hexyl hydroxyoximate, and the dosage of 6-aryl amido hexyl hydroximic acid ranges from 100g / t to 3,500g / t; and useful metallic minerals are floated out through a froth flotation method, and the flotation recovery rate can be increased by 2%-5%.

Description

technical field [0001] The invention relates to a 6-aryl amidohexyl hydroxamic acid collector and a preparation method thereof in the flotation of tungsten ore, rare earth ore, tin ore or bauxite. Background technique [0002] Hydroxamic acid compounds are a typical metal chelating agent. Because of their unique coordination ability with metal ions, hydroxamic acid and its salts have been widely used in oxide ore flotation collectors. Common target minerals include Such as fluorite, wolframite, wolframite, cassiterite, muscovite, phosphatite, hematite, pyrolusite, rhodonite, chrysocolla, malachite, barite, calcite and rare earth. [0003] At present, the hydroxamic acid containing aryl group used in mineral flotation has benzohydroxamic acid collector. Gao Yude et al. reported the research on the flotation solution of tungsten ore collected by benzohydroxamic acid (see structural formula a, Gao Yu De et al., Nonferrous Metals (Mineral Processing Part), 2003(4):28-31.). Pat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B03D1/016B03D101/02
Inventor 钟宏王帅邓兰青黄志强刘广义曹占芳
Owner CENT SOUTH UNIV
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