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Medical adsorbent and method for producing same

A manufacturing method and adsorbent technology, applied in medical science, chemical instruments and methods, absorbent pads, etc., can solve the problems of reducing particle size, not necessarily sufficient adsorption performance, and large dosage, and achieve high effect and high adsorption capacity. Excellent selective adsorption and the effect of suppressing environmental burden

Inactive Publication Date: 2013-08-21
FUTAMURA CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, with existing pharmaceutical activated carbons, it is difficult to reduce the particle size while maintaining the shape as spherical
In addition, the pore adjustment in the existing medicinal activated carbon is not good, and the adsorption performance may not be sufficient, so the daily dosage must be large
In particular, since patients with chronic renal insufficiency limit the intake of water, swallowing with a small amount of water is a great pain for the patient

Method used

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  • Medical adsorbent and method for producing same
  • Medical adsorbent and method for producing same
  • Medical adsorbent and method for producing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1）

[0062] 2 kg of dissolving pulp LNDP (manufactured by Nippon Paper Chemicals Co., Ltd.) with 90% by weight of α-cellulose per unit weight was immersed in a sodium hydroxide solution (18.5% concentration) at 55° C. for 15 minutes, and then pressed. The remaining sodium hydroxide component was removed to prepare alkali cellulose (AC) having a cellulose concentration of 33.5% by mass. The alkali cellulose was matured at 40°C for 7 hours, and 5 g of the alkali cellulose was reacted with 436 mL of carbon disulfide with a purity of 97% or higher for 70 minutes to obtain xanthate cellulose with a viscosity of 0.055 Pa·s (55 cP) at 40°C.

[0063] After the reaction was finished, about 13L of dilute sodium hydroxide solution was added to the cellulose xanthate, and stirred for 100 minutes to obtain viscose. After further defoaming, aging, and filtering processes, viscose with a cellulose concentration of 9.0% was prepared. Dilute the above-prepared viscose with distilled water to a vis...

Embodiment 2）

[0066] The activation temperature in Example 1 was set to 750° C., and the activation time was set to 2 hours, except that the granular activated carbon of Example 2 was obtained according to Example 1 (the yield was 30.1%).

Embodiment 3）

[0068] The activation temperature in Example 1 was set to 750° C., and the activation time was set to 8 hours, except that the granular activated carbon of Example 3 was obtained according to Example 1 (the yield was 22.6%).

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Abstract

[Problem] To provide a medical adsorbent for oral administration that has excellent adsorption capacity and selective adsorption of toxins that are to be removed, even at low doses, and that is economical and minimizes environmental impact. [Solution] Activated carbon is obtained by the carbonization and activation of purified cellulose or regenerated cellulose, and is characterized by: comprising granular activated carbon in which the pore diameters are 1.5 to 2.2 nm, the specific BET surface area is 700 to 3000 m2 / g, the average particle diameter is 100 to 1100 [mu]m, the amount of surface oxidation is not less than 0.05 meq / g, and the packing density is 0.4-0.8g / mL; and being used as an orally-administered therapeutic agent or preventive agent for renal disease or liver disease.

Description

technical field [0001] The present invention relates to an orally administrable pharmaceutical adsorbent comprising activated carbon made of purified cellulose or regenerated cellulose and a method for producing the same, in particular to an adsorbent derived from fiber having excellent selective adsorption performance and adsorption performance of toxic substances. Oral administration type pharmaceutical adsorbent of prime activated carbon and method for producing the same. Background technique [0002] In patients with kidney disease or liver disease, toxic substances accumulate in the blood, resulting in encephalopathy such as uremia and impaired consciousness. The number of these patients tends to increase year by year. Patients are treated using hemodialysis-type artificial kidneys that remove toxic substances outside the body. However, this kind of artificial kidney requires specialized technical personnel to operate it in terms of safety management. In addition, whe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/44A61P1/16A61P13/12A61P39/02B01J20/20B01J20/30C01B31/10C01B32/336
CPCA61L15/18A61K9/14A61K33/44C01B32/336B01J20/20B01J20/28011B01J20/28004B01J20/3078B01J20/28083B01J20/2808B01J20/28066B01J20/28064A61P1/16A61P13/12A61P39/02B01J20/30
Inventor 黑川普之日比圭太高阪务铃木惠介
Owner FUTAMURA CHEM
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