Expandable vaginal suppository

Abstract

The invention relates to an expandable vaginal suppository which comprises a first expansion carrier; a stype layer comprising active constituents and a matrix is used for at least covering an end part of the first expansion carrier; the vaginal suppository is expanded in a water solution with the pH value of 3.0-8.0 according to the predetermined expansion value; and the expansion value of the first expansion carrier in the saturated water absorption process is 1-30. The vaginal suppository can be fully and selectively contacted with vaginal epithelium and mucosal wall, the bioavailability of active drugs is averagely improved by 20-40%, and different positions of a suppository body can be expanded to different degree, so that the problem of low possibility of cleaning a sliver vaginal suppository is thoroughly solved and the problems of poor user compliance, strong discomfort and the like are avoided.

Description

Technical field [0001] The invention involves an expansion vaginal suppository that transports drugs, which specializes in a vaginal suppositories that can expand the expansion value according to the scheduled expansion value. Background technique [0002] Vaginal suppositories refer to solid preparations made of drugs and appropriate matrix for vaginal administration.The vaginal bolt is generally duck -billed, spherical or ovate, etc., which can be made to make ordinary bolt or continuous release of slow -release bolt.The matrix of water -soluble or water can be used to prepare vaginal bolt.The drugs and matrix in the suppositories should be mixed evenly, the shape of the suppositories should be complete and smooth; there should be no irritation after the cavity channel, it should be melted, softened or dissolved, and mixed with the secretion liquid to gradually release the drug and produce local or systemic effects; There should be a suitable hardness to avoid deformation durin...

AI Technical Summary

Problems solved by technology

[0005] above-mentioned vaginal suppositories are all committed to solving the problem of more accurately providing medicine to the diseased site and contaminated clothing with medicinal liquid, but generally speaking, there are still the following deficiencies: 1. activity Components are not in sufficient contact with the vaginal epithelium and mucous membrane wall, let alone selective contact; 2. The vagina is an open organ, and the medicine can easily slip off or flow out of the medicine liquid after melting or dissolving in the vagina, causing contamination of clothes, and the existing technology solves the problem. The method is to use the blocking method, but the effect is not ideal, and the problem of not being easy to clean has not been completely solved

3. Poor user compliance and strong discomfort

4. No good quality control methods

5. The weight difference is not easy to control, and the content uniformity cannot meet the requirements of the Pharmacopoeia

6. The curative effect of some active ingredients is lower than that of systemic administration

7. The sliver swells irregularly, and the contradiction that the sliver swells rapidly when it encounters water and cannot absorb too much liquid medicine cannot be solved

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