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A kind of preparation method of glucose vinyl ester/isopropylacrylamide copolymer nanofibrous film

A technology of propylacrylamide copolymer and isopropylacrylamide, which is applied in the direction of textiles, papermaking, non-woven fabrics, etc., to achieve the effects of simple operation, economical and environmentally friendly treatment, and simple preparation

Inactive Publication Date: 2016-05-04
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

N-isopropylacrylamide is easily polymerized alone or copolymerized with a common radical polymerization initiator

Method used

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  • A kind of preparation method of glucose vinyl ester/isopropylacrylamide copolymer nanofibrous film
  • A kind of preparation method of glucose vinyl ester/isopropylacrylamide copolymer nanofibrous film
  • A kind of preparation method of glucose vinyl ester/isopropylacrylamide copolymer nanofibrous film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Divinyl adipate and glucose were dissolved in anhydrous pyridine at a certain ratio (4:1, molar ratio), and glucose vinyl ester was synthesized by enzymatic synthesis technology. After the reaction, the crude product was separated and purified by silica gel column chromatography, the eluent was ethyl acetate, and the developing solvent was ethyl acetate, methanol and water (17:3:1, v / v / v). 2 color. Put the glycolipid above in a micropolymerization tube, add a certain amount of N-isopropylacrylamide (the molar ratio of glucose ethylene lipid is 7:1), and use azobisisobutyronitrile (AIBN) (accounting for glucose ethylene Grease and N-isopropylacrylamide total mass fraction is 2.0) as an initiator, adding absolute ethanol as a solvent (monomer concentration is 2.5mol / L absolute ethanol), sealed, vacuumed with an oil pump, and nitrogen gas , repeated many times. The system was placed at 50-60° C. under the protection of nitrogen and stirred for 6 h.

[0038] (2) Add ...

Embodiment 2

[0044] (1) Divinyl adipate and glucose were dissolved in anhydrous pyridine at a certain ratio (4:1, molar ratio), and glucose vinyl ester was synthesized by enzymatic synthesis technology. After the reaction, the crude product was separated and purified by silica gel column chromatography, the eluent was ethyl acetate, and the developing solvent was ethyl acetate, methanol and water (17:3:1, v / v / v). 2 color. Add a certain amount of N-isopropylacrylamide (the molar ratio to glucose ethylene ester is 7:1), and use azobisisobutyronitrile (AIBN) (accounting for the total mass of glucose ethylene ester and N-isopropylacrylamide) The mass fraction is 2.0) as an initiator, add absolute ethanol as a solvent (the monomer concentration is 2.5mol / L absolute ethanol), seal, vacuumize with an oil pump, and pass nitrogen gas, repeating many times. The system was placed at 55-60° C. under the protection of nitrogen and stirred for 6 h.

[0045] (2) Add a certain mass of temperature-sensit...

Embodiment 3

[0051] (1) Divinyl adipate and glucose were dissolved in anhydrous pyridine at a certain ratio (4:1, molar ratio), and glucose vinyl ester was synthesized by enzymatic synthesis technology. After the reaction, the crude product was separated and purified by silica gel column chromatography, the eluent was ethyl acetate, and the developing solvent was ethyl acetate, methanol and water (17:3:1, v / v / v). 2 color. Put the glycolipid above in a micropolymerization tube, add a certain amount of N-isopropylacrylamide (the molar ratio of glucose ethylene lipid is 7:1), and use azobisisobutyronitrile (AIBN) (accounting for glucose ethylene Grease and N-isopropylacrylamide total mass fraction is 2.0) as an initiator, adding absolute ethanol as a solvent (monomer concentration is 2.5mol / L absolute ethanol), sealed, vacuumed with an oil pump, and nitrogen gas , repeated many times. The system was placed at 50-60° C. under the protection of nitrogen and stirred for 6 h.

[0052] (2) Add ...

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Abstract

The invention relates to a preparation method of glucose vinyl ester / isopropyl acrylamide copolymer nanofiber membrane. The preparation method provided by the invention comprises the following steps of: dissolving adipic acid divinyl ester and glucose into anhydrous pyridine, adding alkaline protease, reacting, separating and purifying to obtain glucose ethylene ester; adding N-isopropyl acrylamide, an initiating agent and a solvent into the glucose ethylene ester, then stirring and reacting under the protection of nitrogen, and carrying out polymerization reaction to obtain glucose ethylene ester / isopropyl acrylamide copolymer; and adding the glucose ethylene ester / isopropyl acrylamide copolymer and PLCL into the solvent, stirring to obtain a spinning solution, then carrying out electrostatic spinning, and drying, so that the glucose vinyl ester / isopropyl acrylamide copolymer nanofiber membrane is obtained. The preparation method is simple in operation, products are easy to treat, and the preparation method is economic and environment-friendly; and the nanofiber membrane contains abundant reactive hydrophilic activity functional groups and has a phase transition temperature close to body temperature, so that specific adsorption on surface of material is enhanced while biocompatibility on the surface of the material is improved and multiple potential applications can be realized on the basis of phase transition properties.

Description

technical field [0001] The invention belongs to the field of preparation and application of nanofiber membranes, in particular to a preparation method of glucose vinyl ester / isopropylacrylamide copolymer nanofiber membranes. Background technique [0002] Sugar, like protein, lipid and nucleic acid, is an important component of living organisms. Widely existing glycoconjugates, including glycoproteins, proteoglycans, and glycolipids, are involved in important physiological processes such as protein targeting, cell recognition, and antibody-antigen interactions. Glycosylated membrane has the characteristics of high hydrophilicity, anti-non-specific protein adsorption and high biocompatibility, so it is widely used in protein separation and purification, specific capture of bacteria, biomedical materials and cell culture, etc. On the one hand, it is also possible to prepare surface functionalized separation membranes. People try to immobilize sugar groups on the surface of di...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D04H1/4326D04H1/728C08F220/54C08F218/16
Inventor 朱利民王蕾权静
Owner DONGHUA UNIV
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