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Preparation method of galactose vinyl ester/isopropyl acrylamide copolymer nanofiber membrane

A technology of propylacrylamide copolymer and isopropylacrylamide, which is applied in the direction of textiles, papermaking, non-woven fabrics, etc., to achieve the effects of controllable LCST value, improved biocompatibility, and simple operation

Inactive Publication Date: 2013-06-26
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

N-isopropylacrylamide is easily polymerized alone or copolymerized with a common radical polymerization initiator

Method used

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  • Preparation method of galactose vinyl ester/isopropyl acrylamide copolymer nanofiber membrane
  • Preparation method of galactose vinyl ester/isopropyl acrylamide copolymer nanofiber membrane
  • Preparation method of galactose vinyl ester/isopropyl acrylamide copolymer nanofiber membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039](1) Divinyl azelate and galactose were dissolved in anhydrous pyridine at a certain ratio (4:1, molar ratio), and galactose vinyl ester was synthesized by enzymatic synthesis technology. After the reaction, the crude product was separated and purified by silica gel column chromatography, the eluent was ethyl acetate, and the developing solvent was ethyl acetate, methanol and water (17:3:1, v / v / v). 2 color. Put the above-mentioned glycolipids in a micropolymerization tube, add a certain amount of N-isopropylacrylamide (the molar ratio to glucose ethylene lipid is 7:1), and use azobisisobutyronitrile (AIBN) (accounting for galactose Vinyl ester and N-isopropylacrylamide (the mass fraction of the total mass is 2.0) as the initiator, adding absolute ethanol as the solvent (the monomer concentration is 2.5mol / L absolute ethanol), sealed, and vacuumized by an oil pump Nitrogen, repeated several times. The system was placed at 50-60° C. under the protection of nitrogen and st...

Embodiment 2

[0046] (1) Divinyl azelate and galactose were dissolved in anhydrous pyridine at a certain ratio (4:1, molar ratio), and galactose vinyl ester was synthesized by enzymatic synthesis technology. After the reaction, the crude product was separated and purified by silica gel column chromatography, the eluent was ethyl acetate, and the developing solvent was ethyl acetate, methanol and water (17:3:1, v / v / v). 2 color. Add a certain amount of N-isopropylacrylamide (the molar ratio of galactose vinyl ester is 7:1), and use azobisisobutyronitrile (AIBN) (accounting for galactose vinyl ester and N-isopropylacrylamide The mass fraction of the total mass is 2.0) as an initiator, adding absolute ethanol as a solvent (the monomer concentration is 2.5mol / L absolute ethanol), sealing, vacuuming with an oil pump, and passing nitrogen gas, repeating many times. The system was placed at 55-60° C. under the protection of nitrogen and stirred for 6 h.

[0047] (2) Add a certain mass of temperat...

Embodiment 3

[0053] (1) Divinyl azelate and galactose were dissolved in anhydrous pyridine at a certain ratio (4:1, molar ratio), and galactose vinyl ester was synthesized by enzymatic synthesis technology. After the reaction, the crude product was separated and purified by silica gel column chromatography, the eluent was ethyl acetate, and the developing solvent was ethyl acetate, methanol and water (17:3:1, v / v / v). 2 color. Put the above-mentioned glycolipid in a micropolymerization tube, add a certain amount of N-isopropylacrylamide (the molar ratio of galactose vinyl ester is 7:1), and use azobisisobutyronitrile (AIBN) (accounting for half The total mass fraction of lactose vinyl ester and N-isopropylacrylamide is 2.0) as an initiator, add absolute ethanol as a solvent (monomer concentration is 2.5mol / L absolute alcohol), seal, and vacuumize with an oil pump Nitrogen, repeated several times. The system was placed at 50-60° C. under the protection of nitrogen and stirred for 6 h.

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Abstract

The invention relates to a preparation method of a galactose vinyl ester / isopropyl acrylamide copolymer nanofiber membrane. The preparation method comprises the following steps of: dissolving divinyl azelate ester and galactose in anhydrous pyridine, adding alkaline protease, reacting, and separating and purifying to obtain galactose vinyl ester; adding the galactose vinyl ester into N-isopropyl acrylamide, an initiator and a solvent and then, and stirring to perform reaction under the protection of nitrogen, wherein after copolymerization reaction, the galactose vinyl ester / isopropyl acrylamide copolymer is obtained; adding the copolymer and PLCL [poly(L-lactide-co-epsilon-caprolactone)], stirring to obtain spinning liquid, and then, statically spinning and drying to obtain the galactose vinyl ester / isopropyl acrylamide copolymer nanofiber membrane. The method is simple to operate, the products are easy to treat and the method is economical and environment-friendly. The membrane with galactose fixed on the surface is used for separating and purifying proteins, and has thermosensitive property and more potential applications.

Description

technical field [0001] The invention belongs to the field of preparation and application of nanofiber membranes, in particular to a preparation method of galactose vinyl ester / isopropylacrylamide copolymer nanofiber membranes. Background technique [0002] Sugar, like protein, lipid and nucleic acid, is an important component of living organisms. Sugar plays an important role in the construction of cells, the biosynthesis of cells and the regulation of cell life activities. Widely existing glycoconjugates, including glycoproteins, proteoglycans, and glycolipids, are involved in important physiological processes such as protein targeting, cell recognition, and antibody-antigen interactions. In recent years, the study of its structure and function has become another important subject after DNA and protein, and has attracted people's attention. People try to immobilize sugar groups on the surface of different carriers to simulate various biological functions of sugar, so as t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/4326D04H1/728C08F220/54
Inventor 朱利民王蕾权静
Owner DONGHUA UNIV
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