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Sanggenone C and sanggenone D extracted from morus plants and new medicine application of composition

A technology of mulberry ketone and composition, which is applied in the field of new medical applications of mulberry ketone C, mulberry ketone D and their compositions extracted from Morus plants, and can solve the problems of no clear pharmacodynamic ingredients and the like

Inactive Publication Date: 2013-06-19
赵全成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Invention patents such as Wang Lin (publication number: CN101955487A) reported a method for preparing mulperin, but did not clarify the pharmacodynamic components

Method used

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  • Sanggenone C and sanggenone D extracted from morus plants and new medicine application of composition
  • Sanggenone C and sanggenone D extracted from morus plants and new medicine application of composition
  • Sanggenone C and sanggenone D extracted from morus plants and new medicine application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1, Extraction preparation of each single compound

[0052] The preparation method of Sanggenone C, Sanggenone D and Sangbarin: 10kg of Cortex Morus alba is crushed into coarse powder, firstly add 2000g of calcium oxide, then add 8 times the amount of 70% ethanol solution to reflux and extract 3 times, each time for 2 hours , adjust the pH of the extract to 7, recover ethanol until it has no alcohol smell, add AB-8 macroporous resin column for adsorption, wash 4 column volumes with water, then elute 4 column volumes with 70% ethanol solution, collect ethanol elution Liquid, recover ethanol, add acid to the concentrated solution to adjust pH = 2, set aside for precipitation; filter out the precipitate, reflux with 8 times the amount of acetone, filter while hot, add silica gel column, gradient elution with acetone aqueous solution, collect active ingredients, recover acetone and place for crystallization ; Crude crystals were filtered out, using methanol-water...

Embodiment 2

[0056] Embodiment 2, Preparation of the composition

[0057] Take 4g of mulgenone C, 3.5g of mulberry ketone D, 1g of mulperin, 0.5g of mulperiside, 0.3g of oxidized resveratrol, 0.2g of resveratrol, 0.5g of deoxynojirimycin, and mix well A composition of the invention is obtained.

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Abstract

The invention discloses sanggenone C and sanggenone D extracted from white mulberry root-barks, mulberry twigs and folium leaves and a new medicine application of a composition comprising the sanggenone C and the sanggenone D which are main ingredients, particularly the application of the single ingredient sanggenone C or sanggenone D and the composition composed of the sanggenone C, the sanggenone D, mulberrin, mulberroside, oxidized resveratrol, resveratrol and deoxynojirimycin in preparation of alpha-glucosidase inhibitor medicines. The composition is prepared by respectively extracting medicinal materials containing the chemical components above and blending according to certain proportions, or using several extraction methods for extracting the medicinal materials simultaneously containing the chemical components above. The white mulberry root-barks, the mulberry twigs and the folium leaves are accidentally found to contain the sanggenone C and the sanggenone D apart from containing alkaloids such as deoxynojirimycin; and the sanggenone C and the sanggenone D have stronger pharmacological activity than the alkaloids such as deoxynojirimycin.

Description

technical field [0001] The present invention relates to the new medical application of Sanggenone C and Sanggenone D extracted from Morus Alba Cortex, Morus twigs and mulberry leaves, and the composition mainly composed of Sanggenone C and Sanggenone D. Specifically, It is a single component of mulberry ketone C and mulberry ketone D, with mulberry ketone C and mulberry ketone D as the main components, and then mixed with an appropriate amount of mulberry, mulberry glycoside, oxidized resveratrol, and resveratrol The application of the composition composed of deoxynojirimycin and deoxynojirimycin in the preparation of α-glucosidase inhibitor medicine also relates to the pharmaceutical preparation of the medicine, and the invention belongs to the technical field of medicine. Background technique [0002] Diabetes is currently the second most common disease after tumors and cardiovascular and cerebrovascular diseases. Recent studies have found that postprandial hyperglycemia o...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61K31/445A61K31/352A61K31/05A61P3/10A23L1/30C07D493/04C07H15/203C07H1/08C07D211/46C07C39/21C07C37/70
Inventor 南敏伦赫玉芳赵全成赵昱玮常艳茹王莲萍
Owner 赵全成
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