Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of tetraphenylporphyrin and amino polycarboxylic acid, which is applied in the field of medicine, can solve problems such as poor solubility, influence on the stability of curative effect, and molecular polarity reduction, and achieve broad application prospects, high fluorescence quantum yield and Effects of optical stability, good biocompatibility
Active Publication Date: 2013-06-12
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
View PDF2 Cites 6 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, due to the strong fat solubility of porphyrin itself, and the introduction of four benzene rings, its molecular polarity becomes smal...
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0026] Example 1 tablet
[0027] Get 0.3kg amino polycarboxylic acid modified tetraphenylporphyrin compound, add 0.5kg starch, 0.1kg magnesium stearate, 0.2kg carboxymethyl cellulose, 2.7kg ethanol (volume percentage composition is 70%), 2.5kg Microcrystalline cellulose and 3.2kg cornstarch are mixed thoroughly to form wet granules, dried at 60-70°C for 2-4 hours, and pressed into tablets. Tablets are made into tablets. The excipients used as excipients include magnesium sulfate, corn starch, and talcum powder. The specifications are: 5mg, 10mg, 20mg, 50mg, and 100mg.
[0028] In practice, the tetraphenylporphyrin compound modified with aminopolycarboxylic acid is the compound represented by the following formula (I) and its pharmaceutically acceptable salts such as potassium salt, sodium salt, ammonium salt and the like.
[0029]
[0030] Among them, R 1 = H, OH, OCH 3 ;
[0031]
Embodiment 2
[0032] Embodiment 2 capsules
[0033] Get 0.3kg amino polycarboxylic acid modified tetraphenylporphyrin compound, add 0.02kg magnesium stearate, 0.2kg carboxymethyl cellulose, 0.48kg microcrystalline cellulose, fully stir and mix to make wet granules, and make the The wet granules are directly dried at 60-70° C. for 2-4 hours, and then filled into empty capsule shells, and each capsule contains 20 mg of amino polycarboxylic acid modified tetraphenylporphyrin compound.
Embodiment 3
[0034] Embodiment 3 sustained and controlled release tablet
[0035] Get 0.3kg aminopolycarboxylic acid modified tetraphenylporphyrin compound, add 0.07kg hydroxypropyl methylcellulose, 0.25kg carboxymethylcellulose, 0.37kg ethanol (volume percentage is 70%), 0.1kg hard Magnesium fatty acid, etc. are fully stirred and mixed to form wet granules, dried at 60-70°C for 2-4 hours, and pressed into tablets.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Login to view more
Abstract
The invention discloses a photosensitive medicinal preparation containing amino poly-carboxylic acid modification tetraphenylporphyrin compound. Each unit dose contains 1mg-100mg of the amino poly-carboxylic acid modification tetraphenylporphyrin compound. The each unit dosage is the total amount of the medicinal preparation used everyday. The amino poly-carboxylic acid modification tetraphenylporphyrin compound can be used in combination with other medicine or is singly used. Through addition of a drug carrier which is acceptable in pharmacy, the amino poly-carboxylic acid modification tetraphenylporphyrin compound accounts for 0.5%-40% the total weight of the medicinal preparation and can be prepared to any dosage form accepted clinically. The invention further provides application of the medicinal preparation on preparation of photosensitive antitumor drug and in the near infrared fluorescence imaging filed. The photosensitive medicinal preparation containing the amino poly-carboxylic acid modification tetraphenylporphyrin compound is low in toxicity, convenient to apply, wide in tumor suppression spectrum, good in tumor control rate, good in effect of malignant tumor treatment through photodynamic therapy, high in fluorescence quantum yield and optical stability in a near-infrared area, good in biocompatibility, capable of having a certain ability of penetrating the biological barrier, and wide in application prospect in the near infrared fluorescence imaging field.
Description
technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical preparation containing amino polycarboxylic acid modified tetraphenylporphyrin compound and its application in photodynamic therapy of tumors and near-infrared fluorescence imaging. Background technique [0002] Photodynamic therapy (PDT) is a new technology for tumor treatment that came out in the late 1970s. It is the product of the organic combination of laser technology, light guide technology, optical information processing technology, biophotochemical technology and modern medical technology. At present, it has been approved and recognized by the health departments of many countries, and has become a routine method of tumor treatment, which is widely promoted and applied clinically. [0003] Because malignant tumors have the characteristics of rapid growth, easy recurrence, and easy metastasis, it is difficult to eradicate tumors and take into ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more
IPC IPC(8): A61K41/00A61K49/00A61P35/00
Inventor 刘天军洪阁曹波陈靖京毛丽娜吕丰
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
Login to view more 
Login to view more