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Traditional Chinese medicine composite with immune function and used for treating mastitis of cows

A technology of immune function and composition, which is applied in the direction of drug combination, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve the problems of preventing drugs from entering the inflammatory area and reducing the effect of drug use, so as to improve immunity and non-toxic Side effects, effects without drug resistance

Active Publication Date: 2013-06-12
SHANDONG NEW HOPE LIUHE GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, tissue edema also hinders the entry of drugs into the inflammatory area, reducing the effect of various drugs

Method used

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  • Traditional Chinese medicine composite with immune function and used for treating mastitis of cows
  • Traditional Chinese medicine composite with immune function and used for treating mastitis of cows
  • Traditional Chinese medicine composite with immune function and used for treating mastitis of cows

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Effect test

preparation example Construction

[0062] The present invention also provides a preparation method of the above-mentioned Chinese medicine composition, when the dosage form of the Chinese medicine composition is a decoction, specifically:

[0063] Mix the raw materials in proportion, stir and pulverize them, add 5-8 times the water relative to the sum of the raw materials, decoct for 2-4 hours, filter the decoction, and add the filter residue 2~8 times the sum of the raw materials. 4 times water, decoct again for 2-4 hours, filter the decoction, combine the filtrates, heat and concentrate to obtain a decoction with a crude drug concentration of 1g / ml.

[0064] The decoction prepared by the invention is directly given to cows by gavage.

[0065] The present invention also provides a preparation method of the above-mentioned Chinese medicine composition. When the dosage form of the Chinese medicine composition is a powder, specifically mixing the raw materials in proportion, stirring and pulverizing, adding 5-8 t...

Embodiment 1

[0071] Embodiment 1 Chinese medicine injection 1

[0072] Passepartout 20g, licorice 35g, Polygonatum 65g, Viola 25g, Pulsatilla 40g, Pearl ginseng 60g, Eucommia 45g, Daqingye 60g, Myrrh 25g, Moutan bark 40g, Loquat leaves 20g, Coptis 55g, Shouwu vine 40g, white peony 35g, turmeric 35g, astragalus 85g, Atractylodes macrocephala 55g, jujube 25g, schisandra 45g and ginseng 35g, mix, stir and grind, add 5.2kg water, decoct for 4 hours, filter the decoction, and add the filter residue again 2.5kg of water, decocted for 4 hours again, filtered the decoction, combined the filtrate, added 2g of activated carbon, boiled for 15 minutes, cooled naturally, centrifuged and filtered to obtain the filtrate, heated and concentrated until the alcohol concentration was 15g / ml of liquid medicine, take 20ml of the liquid medicine, add 0.75ml Tween-80 and 100mg sodium sulfite in turn, mix well, add water for injection to 100ml, and adjust the pH value to 7.5 with sodium hydroxide, and finally pa...

Embodiment 2

[0073] Example 2 Toxicity Test of Chinese Medicine Injection 1

[0074] Divide 50 mice randomly into 5 groups, 10 in each group, and ensure that there are half male and half male. The route of administration is intraperitoneal injection, and the dose range of 0% and 100% animal death of Coptis chinensis injection is 4000-12000 mg / kg body weight obtained through the pilot test, divided into four dose groups and a control group, and the dose ratio between the groups is 1:0.8. Oral dosages were 7680mg / kg, 9600mg / kg, 12000mg / kg, 15000mg / kg, intraperitoneal injection dosages were the same as oral dosages, and intraperitoneal injections (0.4mL) of normal saline in the control group. The experimental period was 7 days, and the clinical manifestations and death of animals were observed.

[0075] After administration, the appearance of the mice in each group was bright, their behaviors were normal, no abnormal pathological nerve reflexes appeared, they ate well for seven days, and no...

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Abstract

The invention provides a traditional Chinese medicine composite with an immune function and used for treating mastitis of cows. The traditional Chinese medicine composite contains the following crude medicines: sweetgum fruits, liquorice, rhizoma polygonati, herba violae, Chinese pulsatilla roots, rhizoma panacis majoris, eucommia bark, folium isatidis, myrrh, cortex moutan, folium eriobotryae, coptis roots, multiflower knotweed vines, white paeony roots, turmeric, radix astragali, rhizoma atractylodis macrocephalae, fructus choerospondiatis, schisandra chinensis and radix glehniae. The traditional Chinese medicine composite is capable of improving the immunity of the cows simultaneously when clearing heat, detoxifying, and anti-bacterially decreasing inflammation, thereby improving the anti-stress and the anti-disease capability of the cows; and the traditional Chinese medicine composite has the advantages of good treatment effect, reoccurrence prevention, no medicine resistance, no residue, and no toxic and side effects in treating mastitis of the cows.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine immunization, in particular to a traditional Chinese medicine composition with immune function for treating cow mastitis. Background technique [0002] The mammary gland of a dairy cow is a complex bioreactor in the body. Inside the mammary gland, many protective factors, including cytokines, antibodies, hormones, enzymes and neurotransmitters, etc., together build multiple intricate signaling pathways. The dynamics between these factors Balance is fundamental to maintaining breast health. When inflammation occurs in the mammary glands of dairy cows, the body's resistance decreases, and the expression of cytokines and their receptors in the body will be abnormal. [0003] Cow mastitis (mastitis) refers to a certain type of inflammation in the mammary gland tissue of cows, accompanied by physical, chemical and microbiological changes in milk in different degrees. It is one of ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P37/04A61P15/14
Inventor 陈正平吕明斌燕磊
Owner SHANDONG NEW HOPE LIUHE GROUP
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