Ionic crosslinked PVA (polyvinyl alcohol) mandruka and preparation method and application thereof

Abstract

The invention provides ionic crosslinked PVA (polyvinyl alcohol) mandruka which is prepared from the following components in percentage by weight: 5-15% of PVA, 10-20% of absolute ethyl alcohol, 40-80% of deionized water, 10-30% of ionic crosslinking agent, 1-10% of foaming agent and 1-10% of inorganic acid. The invention also provides a preparation method of the ionic crosslinked PVA mandruka. The invention further provides application of the ionic crosslinked PVA mandruka. The preparation method provided by the invention solves the problem that harmful substances such as acid, aldehyde and the like are left in PVA hydrogel by a chemical crosslinking method in the prior art; the ionic crosslinked PVA mandruka has the characteristics of convenience in use, high biosafety performance, good hemostatic effect, no adhesion, good mechanical performance and the like, and is applicable to the patients of all ages with different nasal cavity sizes; and moreover, the comfort of the patient is greatly improved, the convenience in doctor operation is enhanced, and the risk of cross infection is reduced.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to an ion-crosslinked PVA porous sponge, a preparation method and application thereof. Background technique [0002] Hydrogel (Gel) refers to a three-dimensional network structure polymer containing a large number of solvents. Its network consists of a macromolecular backbone and contains hydrophilic (polar) groups and hydrophobic (non-polar) groups, or has The side chain composition of the dissociative group. [0003] According to the different bonding modes of hydrogel network, it can be divided into physical gel and chemical gel. Physical gel is formed by physical forces such as electrostatic interaction, hydrogen bonding, chain entanglement, etc. This kind of gel is non-permanent and can be transformed into a solution by heating the gel, so it is also called pseudogel or thermoreversible gel. Chemical gel is a three-dimensional network polymer formed by cross-linking chemica...

AI Technical Summary

Problems solved by technology

The disadvantage is that the intermolecular force is relatively weak and the stability of the gel is poor.

The disadvantage is that chemical components such as aldehydes, inorganic acids and epichlorohydrin are added, and the residual components are difficult to completely remove, which may be harmful to the human body and affect the biosafety performance of the final product to a certain extent

This method is also divided into two types, one is the PVA hydrogel that does not add cross-linking agent radiation cross-linking, the hydrogel biosafety obtained in this way is also better, but the mechanical properties are very poor; the second is adding PVA gel obtained by radiation crosslinking of crosslinking agent, this method has similar advantages and disadvantages to chemical method

[0009] In summary, PVA hydrogels prepared by chemical methods (including adding radiation cross-linking agents) have residual components that are difficult to completely remove, and there are biological safety issues in the use of human nasal cavity hemostasis.

The PVA hydrogel prepared by the conventional physical freezing-thawing method has good biological safety, but has the problem of poor mechanical properties