Preparation method of compound analgin injection for livestock
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Analgin and injection technology, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as discoloration and unstable properties of Analgin injection, and achieve Expansion of medicinal scope and use, prevention of inflammatory reactions, and effects of reducing the effects of high temperature
Active Publication Date: 2014-12-10
金河牧星(重庆)生物科技有限公司
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[0004] The invention provides a compound analgin injection for veterinary use and a preparation method thereof, which solves the technical problems of unstable properties such as discoloration of the analgin injection
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Embodiment 1
[0035] 10% Veterinary Compound Analgin Injection
[0036] 1. Formula
[0037] Analgin: 10g, L-cysteine: 2g, dexamethasone sodium phosphate: 50mg, EDTA-Na2: 0.05g, water for injection; 10ml of 0.5mol / L sodium hydroxide solution and one part of hydrochloric acid spare.
[0038] 2: Preparation method
[0039] Take 80% of the prescribed amount of water for injection and let it cool to 20°C, fill it with nitrogen for 10 minutes, then add EDTA-Na2, L-cysteine, and Sulpyrine in sequence, stir to dissolve them all, and adjust a small amount of pH regulator to Between 5.5 and 6.5, prepare liquid A and set aside;
[0040] Take a small amount of water for injection and dissolve dexamethasone sodium phosphate to prepare liquid B;
[0041] Add the above liquid B into liquid A and stir evenly, and continue to stir for 20 minutes. After the liquid is clear, use the pH regulator again to adjust the pH value between 5.5-6.5 and constant volume.
[0042] Obtain the filtrate after filtering...
Embodiment 2
[0045] 20% Veterinary Compound Analgin Injection
[0046] 1. Formula
[0047] Analgin: 20g, L-cysteine: 3g, dexamethasone sodium phosphate: 100mg, EDTA-Na2: 0.05g, water for injection, 10ml of 0.5mol / L sodium hydroxide solution and one part of hydrochloric acid spare.
[0048] 2: Preparation method: the same as the method described in Example 1.
Embodiment 3
[0050] 30% Veterinary Compound Analgin Injection
[0051] 1. Formula
[0052] Analgin: 30g, L-cysteine: 4g, dexamethasone sodium phosphate: 150mg, EDTA-Na2: 0.05g, water for injection, 10ml of 0.5mol / L sodium hydroxide solution and one part of hydrochloric acid spare.
[0053] 2: Preparation method: the same as the method described in Example 1.
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Abstract
The invention relates to a compound analgin injection for livestock and a preparation method thereof. Every 100ml of injection comprises 10-30g of analgin, 2-4g of L-cysteine, 50-150mg of dexamethasone sodium phosphate, 0.05g of EDTA-Na2, water for injection to 100mg, and pH regulator (for regulating the pH value to 5.5-6.5). The preparation method comprises the following steps: dissolving dexamethasone sodium phosphate to prepare a solution, dissolving the other components into a solution, merging the two solutions, stirring uniformly, regulating the pH value to 5.5-6.5 while continuing stirring, and diluting to the specified volume; and filtering the liquor through an organic filter membrane, respectively filling the filtrate into bottles by a filling and sealing machine, sterilizing at 115 DEG C under the pressure of 0.2 MPa for 20 minutes, opening the sterilizing cabinet, naturally cooling for 10 minutes, closing the sterilizing cabinet, and sterilizing again for 20 minutes, thereby obtaining the finished product. The invention solves the problems of discoloration, content degradation, toxicity increase and the like in the injection storage process. The invention has better antipyretic effect, and is endowed with anti-inflammatory and antiallergic functions. The invention improves the appearance quality and curative effect of the product. The invention is more convenient to use, and has wider application range.
Description
technical field [0001] The invention relates to a veterinary drug, in particular to a veterinary compound Analgin injection and a preparation method thereof. Background technique [0002] Analgin (Metamizole Sodium Tablets), a common veterinary prescription drug. It is a combination compound of aminopyrine and sodium sulfite, which can be absorbed rapidly in animals and act quickly, and the drug effect can be maintained for 3-4 hours. The antipyretic effect is more significant, the analgesic effect is also stronger, and has certain anti-inflammatory and anti-rheumatic effects. No significant effect on gastrointestinal motility. For febrile illness, muscle pain, colic and rheumatism etc. [0003] In the actual clinical use of veterinarians, Analgin injection generally has the problem of discoloration of the color of the drug solution in the same box. It is recorded in the 2010 edition of "Chinese Veterinary Pharmacopoeia" that the properties of Analgin Injection: This pro...
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