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Application of acanthopanax trifoliatus polysaccharide in preparing medicine for treating diabetes

A technology of diabetes medicine and bougainvillea polysaccharides, which is applied in drug combination, metabolic diseases, and pharmaceutical formulations, can solve the problems of high polysaccharide content and lower blood sugar, and achieve good hypoglycemic effect, reduced side effects, and low price.

Active Publication Date: 2013-05-01
迪芬娜健康产业(深圳)集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The polysaccharide content in Bougainvillea is high, especially the polysaccharide content in the stem. There is no report that the polysaccharides in Bougainvillea have the activity of lowering blood sugar.

Method used

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  • Application of acanthopanax trifoliatus polysaccharide in preparing medicine for treating diabetes
  • Application of acanthopanax trifoliatus polysaccharide in preparing medicine for treating diabetes
  • Application of acanthopanax trifoliatus polysaccharide in preparing medicine for treating diabetes

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Embodiment Construction

[0021] The present invention will be further described below in conjunction with specific experiments, but not limited thereto.

[0022] Extraction of Polysaccharides from Bougainvillea

[0023] Weigh 430g of dry powdered white bougainvillea medicinal material (the stem of Acanthopanax trifoliatus (Linn.) Merr. of Araliaceae), add 4 times the weight of distilled water, extract in a constant temperature water bath at 80°C for 6 hours, and filter the residue , and then filter the filtrate to remove the precipitate, concentrate at 80°C to 1 / 4 of the original solution volume, add papain to the concentrated water extract, the amount of papain added is 200,000 IU / g dry powder The white bougainvillea medicinal material, 50 ℃ water bath for 4h, heating to remove enzymes (100 ℃ for 30s), after cooling, add 4 times the volume of 95% ethanol for alcohol precipitation, place at 4 ℃ overnight, centrifuge at 3500r / min for 10min, take the precipitate , and then suction filtered and dried t...

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Abstract

The invention discloses an application of acanthopanax trifoliatus polysaccharide in preparing a medicine for treating diabetes. An experiment proves that acanthopanax trifoliatus polysaccharide can increase the weight of a micemouse with the diabetes obviously, and the recovery capability of acanthopanax trifoliatus polysaccharide on the weight approximates to that of metformin. The experiment also proves that acanthopanax trifoliatus polysaccharide has a better blood glucose decreasing effect, does not affect blood glucose of a normal mouse, and has an obvious recovery effect on the blood glucose of the mouse with the diabetes; and a treatment effect of a high dose group most approximates to that of a contrast medicine, namely the metformin. Acanthopanax trifoliatus is an all-natural plant; the medicine resistance of the traditional Chinese medicine is generally lower; acanthopanax trifoliatus plays an important role during diabetes treatment; a side effect brought by western medicines can be reduced; a stem of acanthopanax trifoliatus contains highest-content polysaccharide; and acanthopanax trifoliatus has the advantage of low cost, therefore, the development of a glucose decreasing effect of acanthopanax trifoliatus has a very high economic value.

Description

technical field [0001] The invention relates to a new application of bougainvillea polysaccharide, in particular to the application of bougainvillea polysaccharide in the preparation of medicines for treating diabetes. Background technique [0002] At present, diabetes has become the third chronic disease that seriously threatens human health after tumors and cardiovascular diseases. Diabetes is an increasingly serious problem in both developed and developing countries. It has caused serious and costly consequences, including Blindness, heart disease, kidney disease, and complications from diabetes. At present, the prevalence of diabetes among people over 40 years old in my country is 5.89%, and it is showing a clear upward trend. According to the estimates of the International Diabetes Federation, the number of diabetic patients in China will exceed 50 million in the next 20 years. Diabetes now tends to expand and rejuvenate. How to prevent and treat diabetes has become a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P3/10
Inventor 潘育方杨慧文刘莉
Owner 迪芬娜健康产业(深圳)集团有限公司
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