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Production method for 20-percent tilmicosin granules

A technology for tilmicosin and a production method, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the bad smell and irritation of tilmicosin, and its bioavailability Low, low applicability and other problems, to avoid first-pass effect, high bioavailability, good taste

Active Publication Date: 2014-08-13
WUXI ZHENGDA POULTRY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional tilmicosin drug has poor dispersion and low bioavailability; in addition, the traditional tilmicosin has bad smell and irritation, resulting in low applicability of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Pretreatment of raw and auxiliary materials: heat and melt 15kg insect wax and 10kg PEG4000 respectively; mix 25kg tilmicosin with 10kg microcrystalline cellulose and 4kg VB6 evenly; granulate and coat tilmicosin: mix tilmicosin The evenly mixed powder of Kaoxing, microcrystalline cellulose and VB6 is mixed with 15kg of melted insect wax, extruded and granulated, and passed through a 24-mesh sieve (the drum speed of the granulator is 65r / min). The granules were mixed again with the remaining 20kg of microcrystalline cellulose, and then mixed with melted 10kg of PEG4000, extruded and granulated, and passed through a 20-mesh sieve to obtain a finished product.

Embodiment 2

[0017] Pretreatment of raw and auxiliary materials: heat and melt 25kg insect wax and 15kg PEG4000 respectively; mix 25kg tilmicosin with 15kg microcrystalline cellulose and 6kg VB6 evenly; granulate and coat tilmicosin: mix tilmicosin The powder mixed evenly with microcrystalline cellulose and VB6 is mixed with insect wax, extruded and granulated, and passed through a 24-mesh sieve (the drum speed of the granulator is 65r / min). The granules were mixed evenly with the remaining 18kg of microcrystalline cellulose, and then mixed with melted 15kg of PEG4000, extruded and granulated, and passed through a 20-mesh sieve to obtain a finished product.

Embodiment 3

[0019] Pretreatment of raw and auxiliary materials: heat and melt 35kg insect wax and 20kg PEG6000 respectively; mix 25kg tilmicosin with 20kg microcrystalline cellulose and 8kg VB6 evenly; granulate and coat tilmicosin: mix tilmicosin The powder mixed evenly with microcrystalline cellulose and VB6 is mixed with insect wax, extruded and granulated, and passed through a 24-mesh sieve (the drum speed of the granulator is 65r / min). The granules were mixed evenly with the remaining 10kg of microcrystalline cellulose, and then mixed with 20kg of melted PEG6000, extruded and granulated, and passed through a 20-mesh sieve to obtain a finished product.

[0020] The acid value of the insect wax used in Examples 1-3 is ≤4.0, the saponification value is 70-93, and the iodine value is ≤8.0; the cellulose content in the microcrystalline cellulose is 97.0%-102.0%.

[0021] The palatability test of the product on the pig farm:

[0022] The applicant carried out a palatability test on the ab...

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PUM

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Abstract

A production method for 20-percent tilmicosin granules comprises the following specific steps: firstly, uniformly mixing 25 kg of tilmicosin with part of 40 kg of 30-50 percent by weight of microcrystalline cellulose and 2-8 kg of vitamin B6 to obtain a mixture; secondly, mixing the mixture obtained in the first step with 15-35 kg of fused insectwax for granulating and passing through a sieve with 24 meshes to obtain granules; and thirdly, uniformly mixing the granules obtained in the second step with residual 50-70 percent by weight of microcrystalline cellulose, uniformly mixing the mixture with 10-20 kg of polyethylene glycol 4000 or 6000 in a fusion state for granulating and passing a sieve with 20 meshes to obtain a finished product. According to the product prepared by the production method disclosed by the invention, high dispersion of medicaments is ensured, the dissolving speed is increased, the solubility is increased, the sensitivity of bacteria to the product is effectively enhanced and the biological availability of organism is greatly increased.

Description

technical field [0001] The invention relates to the technical field of feed and feed additives, in particular to a method for producing antibiotics for livestock and poultry. Background technique [0002] Tilmicosin is a macrolide semi-synthesized from tylosin, which is an antibiotic for animals. The chemical name is 4A-O-de(2,6-dideoxy-3-C-methyl-L-ribose-pyranylhexyl)-20-deoxy-20-(3,5-dimethyl-1-piper Pyridyl)-[20(cis:trans)]tylosin. Tilmicosin was successfully developed in the 1980s, approved in most European countries in 1990, approved in the United States in 1992, and included in the United States Pharmacopoeia. [0003] Tilmicosin has a strong antibacterial effect on Gram-negative bacteria, Pasteurella avium multocida, Erysipelothrix erysipeatidis, Actinobacillus pleuropneumoniae and Mycoplasma gallisepticum, and it shows antibacterial effect on other bacteria Weak or resistant. Tilmicosin is mainly used for the prevention and treatment of cattle, sheep, sheep, In...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/706A61K47/38A61P31/04
Inventor 周玲叶锋先冯静波
Owner WUXI ZHENGDA POULTRY
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