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Method for detecting residual disinfecting Cetyltrimethylammonium Chloride used in production process of sodium hyaluronate

A technology of cetyltrimethylammonium chloride and production process, which is applied in the direction of material analysis by observing the influence on chemical indicators, and analysis by chemical reaction of materials, etc., so as to reduce the detection cost and shorten the detection time. effect of time

Active Publication Date: 2013-04-17
SHANGHAI JINGFENG PHARMA
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Problems solved by technology

[0016] The purpose of the present invention is to provide a detection method for disinfection residual cetyltrimethylammonium chloride in the production process of sodium hyaluronate, to solve the safety problem caused by cetyltrimethylammonium chloride residue, The method is accurate in detection, high in inspection cost and efficiency, and convenient for inspection work

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  • Method for detecting residual disinfecting Cetyltrimethylammonium Chloride used in production process of sodium hyaluronate
  • Method for detecting residual disinfecting Cetyltrimethylammonium Chloride used in production process of sodium hyaluronate

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Embodiment

[0030] (1) Weigh cetyltrimethylammonium chloride reference substance, add 2ml of 0.6mol / L hydrochloric acid solution, add water to dissolve to constant volume, and prepare 200μg / ml cetyltrimethylammonium chloride stock solution ; Dilute the cetyltrimethylammonium chloride stock solution to prepare standard solutions of 1 μg / ml, 2 μg / ml, 4 μg / ml, 8 μg / ml, and 10 μg / ml; pipette a certain volume of each standard solution, and set In the test tube, pipette 0.6 mol / L hydrochloric acid solution equal to the volume of the standard solution in the two blank tubes, add 0.5 ml of the modified bismuth potassium iodide test solution to each of the above tubes, mix it in a vortex shaker immediately, and place it at room temperature for 5- 15min, using the blank tube as a control, measure the absorbance at 290nm, and obtain the linear regression equation;

[0031] (2) Preparation of sample solution: Weigh / pippet 5ml of cetyltrimethylammonium chloride sample, add 2ml of 0.6mol / L hydrochloric...

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Abstract

The invention relates to a method for detecting residual disinfecting Cetyltrimethylammonium Chloride (CTAC) used in the production process of sodium hyaluronate. The method comprises the following steps: preparing a CTAC standard solution to structure a linear regression equation; preparing a sample solution, using an improved bismuth potassium iodide test solution for developing and measuring the absorbency value; and calculating the content of the CTAC with the linear regression equation. The structuring method of the linear regression equation is as follows: after using the improved bismuth potassium iodide test solution for developing of the prepared 2 Mug / ml, 4 Mug / ml, 8 Mug / ml, 10 Mug / ml and 20 Mug / ml standard solutions, measuring the absorbency under 290nm. By adopting the method to detect the content of the CTAC, the shortcoming that the content and the residue of the CTAC serving as a disinfectant or a reaction agent can not be monitored at present can be overcome, the detection time is greatly shortened, and the detection cost is lowered. The method provided by the invention is particularly suitable for detecting CTAC in labs.

Description

Technical field: [0001] The invention relates to a method for detecting cetyltrimethylammonium chloride, in particular to a method for detecting residual cetyltrimethylammonium chloride during cleaning and disinfection in the production process. Background technique: [0002] The Chinese alias of cetyl trimethyl ammonium chloride: cetyl trimethyl ammonium chloride; CTAC; 1631, trimethyl cetyl ammonium chloride. [0003] English name: Hexadecyl trimethylammonium chloride, the structural formula is as follows: [0004] [0005] English alias: CTAC; Cetyltrimethylammonium chloride [0006] CAS number: 112-02-7 [0007] Molecular formula: C19H42ClN [0008] Linear molecular formula: CH3(CH2)15N(Cl)(CH3)3 [0009] Molecular weight: 320.00 [0010] Purity: ≥99% [0011] MDL number: MFCD00011773 [0012] Beilstein Number: 3657974 [0013] EC number: 203-928-6 [0014] Hexadecyltrimethylammonium chloride is a white crystalline powder, easily soluble in isopropanol, solub...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/78
Inventor 叶湘武付爱玲邱永锋
Owner SHANGHAI JINGFENG PHARMA
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