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Gamma-cytidine-5'-disodium triphosphate crystal compound, and preparation method and drug composition of crystal compound

A technology of disodium triphosphate and cytidine nucleoside, which is applied in the fields of drug combination, preparation of sugar derivatives, chemical instruments and methods, etc., and can solve problems such as the undiscovered crystalline compound of γ-cytidine nucleoside triphosphate disodium , to achieve high crystallinity, improved solubility and stability, and simple and easy-to-control operating conditions

Active Publication Date: 2013-04-17
宁辉
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, the applicant has not found that the crystalline compound of disodium γ-cytidine-5'-triphosphate has been prepared

Method used

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  • Gamma-cytidine-5'-disodium triphosphate crystal compound, and preparation method and drug composition of crystal compound
  • Gamma-cytidine-5'-disodium triphosphate crystal compound, and preparation method and drug composition of crystal compound
  • Gamma-cytidine-5'-disodium triphosphate crystal compound, and preparation method and drug composition of crystal compound

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Abstract

The invention relates to a gamma-cytidine-5'-disodium triphosphate crystal, and a preparation method, a drug composition, and a drug preparation of the crystal. The solubility and the stability of the crystal are better than those of a substance in the prior art, and the crystal is more beneficial for pharmacy and long-term storage. The preparation is particularly suitable for being prepared into an injection and a powder injection.

Description

technical field [0001] The invention belongs to the technical field of drug crystallization, and in particular relates to a crystal of gamma-cytidine-5'-triphosphate disodium, a preparation method thereof, a pharmaceutical composition and a pharmaceutical preparation. Background technique [0002] The structural formula of γ-cytidine-5'-triphosphate disodium is as follows, [0003] , [0004] It belongs to nucleotide derivatives, participates in the synthesis and metabolism of nucleic acid and phospholipids in the body, and promotes protein synthesis. It can also regulate and promote the synthesis and construction of nerve cells, glial cells and blood vessel wall cell membrane structures, and can resist nerve cell damage caused by excitatory amino acids and free radicals, thereby supporting survival, enhancing activity, delaying Death, improve the ability of cells to resist damage, regeneration and repair, promote the regeneration of neurite, and improve the function of ...

Claims

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Application Information

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IPC IPC(8): C07H19/10C07H1/06A61K31/7068A61P25/00A61P9/00A61P9/04A61P1/16
Inventor 宁辉
Owner 宁辉
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