Piracetam pharmaceutical co-crystal using 2,4-dihydroxy-benzoic acid as precursor and preparation method of co-crystal

Abstract

The invention belongs to the technical field of pharmaceutical co-crystals and in particular relates to a piracetam pharmaceutical co-crystal and a preparation method thereof. The space group of the prepared piracetam pharmaceutical co-crystal is a monoclinic system; one piracetam moleculre (1) and one 2,4-dihydroxy-benzoic acid molecule (2) are combined together by a hydrogen bond to form a basic structure unit of the piracetam pharmaceutical co-crystal, wherein the O atom on the hydroxyl group of the 2,4-dihydroxy-benzoic acid molecule is uses as a hydrogen bond donator, and the O atom on the hydroxyl group of the piracetam molecule is used a hydrogen bond acceptor. The solvent selected in the preparation process of the pharmaceutical co-crystal is methanol; and the adopted method is a solvent room-temperature evaporation method. The boiling point of the selected organic solvent is relatively low, and so crystals are separated out in the evaporation process of the solvent. According to the pharmaceutical co-crystal prepared by the preparation method disclosed by the invention, the characteristics of the traditional material medicines for restoring nerve cells are inherited for treating a patient with brain damages; and the solubility, stability and bioavailability of the pharmaceutical co-crystal are remarkably improved.

Description

technical field [0001] The invention belongs to the technical field of drug co-crystals, and in particular relates to a piracetam drug co-crystal with 2,4-dihydroxybenzoic acid as a precursor and a preparation method thereof. Background technique [0002] In 1894, E. Fischer of Germany proposed the "lock-key" model based on the idea of ​​"selective interaction between molecules", which was the prototype of modern supramolecular science theory. In 1937, German K.L.Wolf et al. created the term "supramolecular" to describe highly ordered entities formed by the association of molecules. In a general sense, any collection of molecules has interactions, so people often refer to them as The structural level of matter aggregation state is called "supramolecular". It was not until 1978 that Professor J.M.Lehn of France finally proposed the complete concept of "supramolecular chemistry" based on the traditional research on the host-guest system rooted in organic chemistry. Supramole...

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Problems solved by technology

[0005] Piracetam is a drug for improving brain metabolism, which belongs to the cyclic derivative of Y-aminobutyric acid. It is used for the treatment of cerebrovascular disease and peripheral vascular disease. Cognitive abilities, but not in people with severe dementia

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