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Externally-used traditional Chinese medicine composition for treating cervical HPV infection and preparation method thereof

A technology of composition and traditional Chinese medicine, which is applied in the field of traditional Chinese medicine composition and its preparation, and can solve problems such as differences and incomplete clarity

Active Publication Date: 2013-04-17
薛晓鸥
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the specific mechanism of HPV causing cervical lesions has achieved some results, but it is still not completely clear
[0003] At present, no effective anti-HPV drugs have been found, only conventional antiviral drugs such as acyclovir, and recombinant human interferon preparations, such as Andafen Suppositories, Shurun ​​Suppositories, etc. The motherland's medicine is based on its unique syndrome differentiation and treatment theory. In terms of cervical lesions, the use of traditional Chinese medicine for oral administration and external treatment has good curative effect. According to the analysis of the clinical test results of Chunru gel, the cure rate of cervical erosion in the treatment group was 18.52%, the marked rate reached 34.69%, and the total effective rate was 32.10%. Compared with the control group Compared with the control group, there is a significant difference between the two groups. It is observed that the curative effect of TCM syndrome is better than that of the control group, and the curative effect is affirmative.

Method used

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  • Externally-used traditional Chinese medicine composition for treating cervical HPV infection and preparation method thereof
  • Externally-used traditional Chinese medicine composition for treating cervical HPV infection and preparation method thereof
  • Externally-used traditional Chinese medicine composition for treating cervical HPV infection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0163] Embodiment 1 gel

[0164] Comfrey 40g Phellodendron 40g Curcuma 40g

[0165] Yinhua 30g Sophora flavescens 40g Baibu 40g

[0166] Catechu 30g Bletilla striata 10g borneol 10g

[0167] For the above nine flavors, take zedoary and add 8 times the weight of water, soak for 1 hour, steam distillation and extraction for 8 hours, and obtain zedoary volatile oil; take zedoary volatile oil and borneol and use β-cyclodextrin to make an inclusion complex, and separate Preserve; the distilled aqueous solution of Zedoary is stored in another container; the dregs of Zedoary, Yinhua and Bletilla striata are decocted twice with 8 times the weight of water, each time for 1 hour, and the decoction is combined with the distilled aqueous solution of Zedoary, filtered, Concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.10-1.15 (60-65°C), collect it in another device, and set aside; take comfrey, cortex flavescens, flavescens, centipeda, and cate...

Embodiment 2

[0168] Embodiment 2 Ointment

[0169] The raw materials are:

[0170] Comfrey 40g Phellodendron 40g Curcuma 40g

[0171] Yinhua 30g Sophora flavescens 40g Baibu 40g

[0172] Catechu 30g Bletilla striata 10g borneol 10g

[0173] Take zedoary and add 9 times the amount of water, soak for 1.5 hours, and extract by steam distillation for 7 hours. The volatile oil and borneol are clathrated with β-cyclodextrin to make clathrates, and stored in a separate container. The distilled aqueous solution is stored in a separate container. Add 9 times the amount of water to decoct the slag, Yinhua and Bletilla striata 3 times, 0.5 hours each time, combine the decoction, and combine with the distilled aqueous solution, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.10-1.15 (60-65 ℃) clear the ointment, collect it in another device, and set aside. Comfrey, Cortex Phellodendri, Sophora Sophorae, Herbs, and Catechin were extracted twice with 80% ethano...

Embodiment 3

[0174] Embodiment 3 gel

[0175] Comfrey 40g Phellodendron 40g Curcuma 40g

[0176] Yinhua 30g Sophora flavescens 40g Baibu 40g

[0177] Bletilla striata 10g borneol 10g

[0178] Take zedoary and add 8 times the amount of water, soak for 1 hour, and extract by steam distillation for 8 hours. The volatile oil and borneol are clathrated with β-cyclodextrin to make clathrates, and stored in a separate container. The distilled aqueous solution is stored in a separate container. Add 8 times the amount of water to decoct the slag, Yinhua and Bletilla striata twice, each time for 1 hour, combine the decoction, and combine with the distilled aqueous solution, filter, and concentrate the filtrate under reduced pressure to a relative density of 1.10-1.15 (60-65 ℃) clear the ointment, collect it in another device, and set aside. Comfrey, Phellodendron, Sophora flavescens, and Baibu 4 herbs were extracted twice by adding 80% ethanol to reflux. The first time was 2 hours, 10 times the a...

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Abstract

The invention discloses an externally-used traditional Chinese medicine composition for treating cervical HPV infection and a preparation method thereof; the composition mainly comprises the following raw material herbs of lithospermum, phellodendron, curcuma rhizome, honeysuckle flowers, radix sophorae flavescentis, radix stemonae, bletilla striata, and borneol; the preparation method comprises the following steps: performing water vapor distillation extraction of curcuma rhizome, performing clathration of volatile oil and borneol by using betw-cyclodextrin; decocting the herb residues, honeysuckle flowers and bletilla striata with water, combining with the distilled fluid, filtering and concentrating the mixed fluid to obtain an extract 1; performing ethanol reflux extraction of lithospermum, phellodendron, radix sophorae flavescentis, and radix stemonae, filtering and concentrating to obtain an extract 2; combining the extract 1 with 2; combining the combined extract with the clathrate, adding pharmaceutically acceptable auxiliary materials to prepare a clinically acceptable dosage form for external use. The traditional Chinese medicine composition of the invention has definite and obvious therapeutic effect on treating cervical HPV infection, overcomes the inconvenience of original powder administration, is convenient for clinical application, and has less side effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for treating cervical human papillomavirus infection and a preparation method thereof. Background technique [0002] Cervical cancer (cervical cancer, CC) is a tumor with high incidence in women, and its incidence rate is second only to breast cancer. In 1992, WHO announced that human papillomavirus (human papillomavirus, HPV) infection is the primary factor of cervical canceration. In 1995, the International Cancer The association considers HPV to be the main cause of CC. Epidemiological studies have shown that HPV infection can cause cervical precancerous lesions, namely cervical intraepithelial neoplasia (CIN), which progresses slowly to CC. A large sample study involving 22 countries showed that HPV was detected in 99.7% of tissue samples from patients with CC. The current study shows tha...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P31/20A61P15/00A61K31/045
Inventor 薛晓鸥郭志强谢伟
Owner 薛晓鸥
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