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Ophthalmologic external preparation, as well as preparation method and application thereof

A technology for external preparations and preparation steps, which is applied in the field of medicine and can solve the problems of no ginsenosides, protection of corneal and conjunctival cells, and no ginsenosides for external ophthalmic preparations on the market.

Inactive Publication Date: 2013-04-17
段亚东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there are no studies and literature reports on ginsenosides protecting corneal conjunctival cells, inhibiting goblet cell apoptosis, and treating dry eye syndrome, and there are no drugs listed on the market with ginsenoside ophthalmic preparations for the treatment of dry eye syndrome

Method used

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  • Ophthalmologic external preparation, as well as preparation method and application thereof
  • Ophthalmologic external preparation, as well as preparation method and application thereof
  • Ophthalmologic external preparation, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] Embodiment 1: preparation of ginsenoside eye drops

[0108] Formula composition: ginsenoside 1.0g, sodium hyaluronate 0.1g, sodium chloride 0.5g, potassium chloride 0.0356g, calcium chloride 0.005g, magnesium chloride 0.003g, zinc chloride 0.00012g, glycine 0.1g, with boric acid and borax As a pH regulator, add 0.005 g of benzalkonium chloride and water for injection to 100.0 mL.

[0109] Preparation process: Dissolve ginsenosides in water for injection, stir well with sodium hyaluronate, sodium chloride, potassium chloride, calcium chloride, magnesium chloride, zinc chloride, glycine and benzalkonium chloride respectively, add water for injection to the full amount , stir evenly to make it fully dissolve, adjust the pH value to 6.5-7.8 with boric acid and borax, filter through a 0.22μ microporous membrane to obtain the filtrate, and sterilize it under high pressure at a temperature of 100-120°C for 30-40 minutes, and wait for it After cooling, the aseptic portion is d...

Embodiment 2

[0111] Embodiment 2: Change the preparation of ginsenoside eye drops of thickener

[0112] Formula composition: 0.1 g of sodium hyaluronate in the formula composition of Example 1 is mixed with the following sodium hyaluronate 0.3 g, hypromellose 0.3 g, hypromellose 0.5 g, polyvinyl alcohol 1.4 g, and chondroitin sulfate 1.0 g , chondroitin sulfate 5.0g, carbomer 0.2g, dextran 0.1g, hydroxypropyl methylcellulose 0.3g and glycerol 0.2g complex, polyethylene glycol 0.4g and propylene glycol 0.3g to replace any component.

[0113] Preparation process and usage and dosage: the same as in Example 1.

Embodiment 3

[0114] Embodiment 3: Preparation of ginsenoside eye drops without preservatives

[0115] Formula composition: benzalkonium chloride is removed in the formula composition of embodiment 1, and all the other formulas remain unchanged. Also can form by embodiment 2 formula.

[0116] Preparation process, usage and dosage: The preparation process is the same as in Example 1, except that the prepared ginsenoside eye drops are put into a single-dose eye drop bottle, and the inner capacity of the bottle is 0.3-0.8 ml. The usage and dosage are the same as in Example 1, and it will be discarded after application within 12 hours.

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Abstract

The invention discloses an ophthalmologic external preparation, as well as a preparation method and an application thereof, belongs to the technical field of pharmaceuticals, and relates to a pharmaceutical active substance-ginsenoside which is prepared to form eye drops, oculentum, ophthalmologic gel, ophthalmologic external hydropathic compressing tissues and ophthalmologic external atomized liquid for treating dry eyes. The addition of the ginsenoside is 0.1-5.0 wt%. The ophthalmologic external preparation also is added with one or a plurality of pharmaceutical active substances which are selected from flos lonicerae, radix arnebiae, herba taraxaci, chrysanthemum and borneol. The pharmacodynamical and experimental research of the preparation shows that the ginsenoside has a function of increasing conjunctival goblet cells and effectively treating the dry eyes; and the preparation is safe and effective, is better than conventional single-thickening agent artificial tears and has significant popularization and application values.

Description

technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to the first preparation of ginsenosides into ocular external preparations, and its use in the preparation of ocular external medicines or eye care products for treating dry eye. Background technique [0002] Keratoconjunctivitis sicca, commonly known as dry eye syndrome or dry eye disease or dry eye or dry eye syndrome, is a common ocular surface disease. At present, the traditional treatment for dry eye is to use artificial tears. Artificial tears imitate tears. Liquid), Sodium Hyaluronate (Aili, Hailu Eye Drops), Carbomer (Vidixi Eye Drops), Carboxymethyl Cellulose Sodium (Xiao Lai Wei Eye Drops), Hypromellose ( Yiran, Yingrun eye drops), chondroitin sulfate (Runjie, Runerle eye drops), or compound preparations, such as tearing eye drops (containing dextran, hydroxypropyl methylcellulose and glycerin), new Lairan eye drops (containing dextran and hypromellose), Sira...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K36/35A61K36/30A61K36/288A61K36/28A61P27/02A61K31/045
Inventor 段亚东
Owner 段亚东
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