Preparation method of drug and protein sustained-release alginate hybrid gel
The technology of alginate and hybrid gel is applied in the field of functional materials and biological materials, and can solve the problems of difficult protein slow release in hydrogel, strong hydrophilicity of calcium alginate gel, difficult protein slow release, etc. Achieving the effects of diverse forms, good biocompatibility and good application prospects
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Embodiment 1
[0020] Example 1. A preparation method of doxorubicin sustained-release phosphoric acid / calcium alginate hybrid gel film
[0021] a) Prepare a mixed aqueous solution of 0.5% sodium alginate and 0.5% polyvinyl alcohol by mass percentage, and stand for defoaming; prepare calcium chloride with a mass percentage concentration of 0.5% and a mass percentage concentration at the same time A mixed aqueous solution of 0.05% doxorubicin;
[0022] b) Take the method of scraping film, pour the mixed aqueous solution of sodium alginate and polyvinyl alcohol prepared in step a) on a clean glass plate, scrape it with a scraping film rod with a mold thickness of 1000 μm, and then immediately use step a) The prepared calcium chloride aqueous solution was cross-linked and solidified for 12 hours, and rinsed with deionized water for 3-5 times to obtain a calcium alginate hydrogel film;
[0023]c) Prepare a diammonium hydrogen phosphate aqueous solution with a mass percentage of 0.05%, soak the ...
Embodiment 2
[0024] Example 2. A method for preparing a water-soluble vitamin slow-release carbonic acid / calcium alginate hybrid gel film
[0025] a) Prepare a mixed aqueous solution of 5% sodium alginate and 4% polyethylene glycol by mass percentage, and stand for defoaming; prepare calcium chloride and mass percentage concentration of 15% at the same time A mixed aqueous solution of 1% water-soluble vitamins;
[0026] b) Take the method of scraping film, pour the mixed aqueous solution of sodium alginate and polyethylene glycol prepared in step a) on a clean glass plate, scrape it with a scraping film rod with a mold thickness of 1000 μm, and then immediately use step a ) the prepared calcium chloride aqueous solution was cross-linked and solidified for 0.5 hours, rinsed with deionized water 3-5 times to obtain a calcium alginate hydrogel film;
[0027] c) preparing an aqueous solution of sodium carbonate with a mass percentage of 5%, soaking the calcium alginate hydrogel obtained in st...
Embodiment 3
[0028] Example 3. A preparation method of bovine serum albumin slow-release oxalic acid / calcium alginate hybrid gel microspheres
[0029] a) preparation mass percentage is the mixed aqueous solution of 1.5% sodium alginate and 0.5% carboxymethyl chitosan, stand-by after defoaming; preparation mass percentage concentration is 5% calcium chloride and A mixed aqueous solution of bovine serum albumin with a concentration of 10% by mass percentage;
[0030] b) The method of suspension dispersion is adopted, the mass percentage concentration of ethyl cellulose is 0.1%, the organic matter mixed with butyl acetate and castor oil according to the volume ratio of 1:3 is used as the continuous phase, and the alginic acid obtained in step a) is mixed under stirring The mixed aqueous solution of sodium and carboxymethyl chitosan is dispersed into droplet microspheres with a particle size of 0.5-500 μm, and then immediately poured into the aqueous calcium chloride solution prepared in step ...
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