Carbon nano tube/collagen based composite material and preparation method thereof

A carbon nanotube and composite material technology, which is applied in the field of nanocomposite materials and its preparation, can solve the problems of non-degradability and high plasticity difficulty, and achieves the effects of low tissue repair performance, good biocompatibility, and wide popularization and application value.

Active Publication Date: 2013-04-03
福建省博特生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Studies at home and abroad have shown that although CNTs as a single scaffold material has the advantages of good biomechanical properties, good cell attachment rate and proliferation rate, it also has the disadvantages of difficult plasticity and non-degradability. Therefore, the combination of CNTs and collagen scaffolds Composite promises to address its own flaws

Method used

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  • Carbon nano tube/collagen based composite material and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: prepare carbon nanotube / collagen matrix composite material, concrete steps are as follows:

[0028] (1) Mechanically remove impurities such as subcutaneous muscle, fat and connective tissue from the fish skin rich in collagen, cut it into pieces of about 1mm x 1mm and clean them;

[0029] (2) Wash and degrease with 0.01 mol / L sodium hydroxide, a mixed solution containing 1% hydrogen peroxide and 10% isopropanol solution;

[0030] (3) Dissolved in acetic acid solution with pH 2.0;

[0031] (4) Add protease to the above solution, the mass ratio of collagen to protease is 50:1, enzymatic hydrolysis at 4°C for 24 h;

[0032] (5) Add NaCl to the supernatant collected by centrifugation to make the final concentration 0.9 mol / L, let it stand for 12 hours, centrifuge at 5000r / min for 20 minutes, and collect the precipitate obtained;

[0033] (5) Dissolve the precipitate in 10 times the volume of 0.5mol / L acetic acid solution, and centrifuge to collect the supern...

Embodiment 2

[0037] Embodiment 2: preparation of carbon nanotube / collagen-based composite material, the specific steps are as follows:

[0038] (1) Mechanically remove impurities such as subcutaneous muscle, fat and connective tissue from the fish skin rich in collagen, cut it into pieces of about 1 mm x 1 mm and clean them;

[0039] (2) Wash and degrease with 0.01 mol / L sodium hydroxide, a mixed solution containing 1% hydrogen peroxide and 10% isopropanol solution;

[0040] (3) Dissolved in malonic acid solution at pH 3.0;

[0041] (4) Add protease to the above solution, the mass ratio of collagen to protease is 100:1, enzymolysis at 5°C for 16 h;

[0042] (5) Add KCl to the supernatant collected by centrifugation to make the final concentration reach 0.9 mol / L, let it stand for 10 hours, centrifuge at 5000r / min for 20 minutes, and collect the obtained precipitate;

[0043] (6) Dissolve the precipitate in 10 times the volume of 0.5mol / L acetic acid solution, and centrifuge to collect th...

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Abstract

The invention discloses a carbon nano tube / collagen based composite material and a preparation method of the composite material. The composite material comprises collagen protein and carbon nano tubes, wherein the content of the collagen protein is 96.0-99.8 percent by mass percentage, and the content of the carbon nano tubes is 0.2-4.0 percent by mass percentage. According to the invention, the obtained carbon nano tube / collagen based composite material is provided with favorable biocompatibility, tissue repair property and extremely low immunogenicity; the required raw materials are easy to get; the conditions of the preparation technology are milder; and the composite material is provided with wide popularization and application value.

Description

technical field [0001] The invention belongs to the technical field of nanocomposite materials and their preparation, and in particular relates to a carbon nanotube / collagen-based composite material and a preparation method thereof. Background technique [0002] In recent years, with the rapid increase of the social population and the acceleration of the pace of life, the high incidence of tissue deficiency (disease) damage caused by tumors, infections, decreased physiological functions, and other causes, the frequent occurrence of natural disasters, industrial accidents, and the development of the automobile industry and sports The popularity of sports has resulted in a sharp increase in human accidental injuries and tends to be younger. The repair of the above-mentioned tissue defects (diseases) that pose a great threat to human health requires tissue-guided regeneration materials. [0003] Collagen is the main component of extracellular matrix (ECM) and belongs to struct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L89/00C08K9/00C08K7/00C08K3/04C08J3/24
Inventor 张其清王建华贺超龙程娘梅陈名懋
Owner 福建省博特生物科技有限公司
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