Method for preparing gelatin microballoon embolization agent

Abstract

The invention relates to a method for preparing a gelatin microballoon embolization agent, which comprises the following steps of dissolving gelatin or mixture of gelatin and medicine at 30-70 DEG C, filtering to obtain gelatin solution with 15%-60% of solid content, adding gelatin solution into oil phase liquid paraffin with mass ratio of 1%-2% of stabilizer Span 80, wherein the volume ratio of water and oil is 1 / 1-1 / 10, stirring for 15 minutes by 200-800r / min, adding cross-linking agent aldehyde compound with mass percent of 2%-50% at low temperature of 0-10 DEG C, solidifying for 1-2 hours, washing or drying the cross-linking agent to obtain the microballoon embolization agent after freeze drying or dehydration. The method has the beneficial effects that the gelatin microballoon embolization agent has certain elasticity and expansibility, the surface is smooth, the sphere is obvious, the size and the shape of the sphere is uniform, the grain size is controllable, clinical embolization effect can be improved, and side effect can be lowered, the clinical controllability is strong, antitumor drug can be added into the microballoon in manufacture process, so that double therapeutical effect of medicine treatment and embolization can be realized. The gelatin has good biocompatibility and biodegradablity, and clinical safety can be guaranteed.

Description

technical field [0001] The invention relates to the field of embolic agents, in particular to a preparation method of a gelatin microsphere embolic agent. Background technique [0002] With the maturity of interventional therapy, it has been more and more widely used in the field of medical technology. The principle of interventional therapy is to use a high-definition medical camera to guide a catheter into the tumor site in the human body through a small incision, and then infuse anti-tumor drugs through the blood supply artery or block the blood supply of the tumor tissue, so that the tumor can be cured in a short time. Internal necrosis and atrophy reach the day of treatment. The key technology of interventional therapy is to choose the appropriate embolic agent for blocking the blood supply of tumor tissue. At present, granular embolic agents and liquid embolic agents are mostly used clinically. These embolic agents are often difficult to control and cause serious sid...

AI Technical Summary

Problems solved by technology

The method of the present invention has low cost and relatively simple preparation process, but the prepared embolic agent particles are difficult to separate, the shape is not uniform, the surface size is not uniform, the controllability of particle size classification by sieving is poor, and the product quality is difficult to control