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Water-soluble pore-foaming agent, porous scaffold and preparation method of porous scaffold

A technology of porous scaffolds and porogens, applied in the field of polymer materials and biomaterials, can solve the problems of difficult separation of particles, unsatisfactory scaffold pore structure and connectivity performance, and unobtainable, etc., and achieve the effect of simple and feasible preparation technology

Active Publication Date: 2015-01-07
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mikos and Langer et al. (Mikos et al., Polymer, 1994(35):1068) reported using salt as a porogen. The advantage is that the preparation technology is simple, and the salt porogen can be leached with water. Influenced by the type, the pore structure and connectivity of the obtained scaffold are not ideal; Balls are used as porogens to obtain spherical pores, but the disadvantage is that high porosity cannot be obtained, and connectivity cannot be controlled; P. X. Ma et al. (Peter X. Ma, Tissue Engineering, 2001(7):23-33) used The scaffold made of paraffin balls as porogen has good pore structure and connectivity, but the paraffin leaching process will inevitably use a lot of organic solvents, and a certain amount of paraffin will remain in the scaffold, which will affect the subsequent Tissue construction has adverse effects; P. X. Ma et al. (Peter X. Ma, Journal of Biomedical Materials Research Part A, 2006(78):306-315) also prepared sugar particle porogens thereafter, but the disadvantage of sugar particles is Viscous, the particles are not easy to separate; K.A Gross et al. (K.A Gross, Biomaterials, 2004(25):4955-4962) used a complicated process to spheroidize the salt particles in the flame, and obtained relatively good connectivity, but This kind of rigid spheroid particle porogen has a limited degree of improvement in connectivity, and cannot achieve micron-sized pores and rough pore wall structure on the pore wall; Pore ​​agent, but the preparation process is more complicated, and the method used in the article is not suitable for sodium chloride, because the melting point of sodium chloride is much higher than that of sodium chlorate

Method used

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  • Water-soluble pore-foaming agent, porous scaffold and preparation method of porous scaffold
  • Water-soluble pore-foaming agent, porous scaffold and preparation method of porous scaffold
  • Water-soluble pore-foaming agent, porous scaffold and preparation method of porous scaffold

Examples

Experimental program
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Effect test

Embodiment 1

[0043] Add sodium chloride salt grains into a pulverizer, pulverize for 60 seconds to obtain small salt grains, weigh 50 g of small salt grains and 10 g of sucrose into a round bottom flask, place the beaker in an oil bath, and install a mechanical stirring device. The mechanical stirring speed is 300 rpm / min, under the state of stirring, slowly heat the methyl silicone oil to 170 o C, to dissolve the sucrose and bond the small salt particles together. Due to the continuous mechanical stirring, the small salt particles will not be agglomerated as a whole. After 0.5 h, stop stirring and quickly pour the mixture in the flask into the vibrating screen. In the sieve, use the shaking action of the vibrating sieve machine to further form the small particles of sodium chloride bonded into balls while sieving, and after shaking for 0.5 h, a porogen with a diameter of 50-1000 μm in pore size distribution is obtained.

Embodiment 2

[0045] Add sodium chloride salt grains into a pulverizer, pulverize for 60 seconds to obtain small salt grains, weigh 50 g of small salt grains and 10 g of sucrose into a round bottom flask, place the beaker in an oil bath, and install a mechanical stirring device. The mechanical stirring speed is 100 rpm / min, under the state of stirring, slowly heat the methyl silicone oil to 170 o C, to dissolve the sucrose and bond the small salt particles together. Due to the continuous mechanical stirring, the small salt particles will not be agglomerated as a whole. After 0.5 h, stop stirring and quickly pour the mixture in the flask into the vibrating screen. In the sieve, use the shaking action of the vibrating sieve machine to further form the small particles of sodium chloride bonded into balls while sieving, and after shaking for 0.5 h, a porogen with a diameter of 50-1000 μm in pore size distribution is obtained.

Embodiment 3

[0047] Add sodium chloride salt grains into a pulverizer, pulverize for 60 seconds to obtain small salt grains, weigh 50 g of small salt grains and 10 g of sucrose into a round bottom flask, place the beaker in an oil bath, and install a mechanical stirring device. The mechanical stirring speed is 200 rpm / min, under the state of stirring, slowly heat the methyl silicone oil to 170 o C, to dissolve the sucrose and bond the small salt particles together. Due to the continuous mechanical stirring, the small salt particles will not be agglomerated as a whole. After 0.5 h, stop stirring and quickly pour the mixture in the flask into the vibrating screen. In the sieve, use the shaking action of the vibrating sieve machine to further form the small particles of sodium chloride bonded into balls while sieving, and after shaking for 0.5 h, a porogen with a diameter of 50-1000 μm in pore size distribution is obtained.

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Abstract

The invention belongs to the technical field of a high polymer material and a biological material, and particularly relates to a water-soluble pore-foaming agent and a preparation method thereof, and a porous scaffold prepared from the pore-foaming agent. The pore-foaming agent disclosed by the invention comprises water-soluble particles which are prepared from salt such as sodium chloride and sugar taken as a binder in a bonding manner, and are spherical or similar to be spherical, and the surface of the pore-foaming agent has a topological structure. The water-soluble pore-foaming agent is simple in preparation process as well as convenient and practical; mesopores of the prepared scaffold are good in connectivity; and the topological structure in the pore-foaming agent can be transferred into the scaffold in the preparation of the three-dimensional porous scaffold, and thus, the surface topological shape on the surface of each hole of the three-dimensional porous scaffold is can be modified.

Description

technical field [0001] The invention belongs to the technical field of polymer materials and biomaterials, and in particular relates to a water-soluble porogen, a preparation method thereof, and a porous support with topological morphology on the inner surface obtained by using the porogen. Background technique [0002] The emergence of tissue engineering will make people enter a new era of organ manufacturing from the traditional method of organ transplantation and implantation. The three elements of tissue engineering include: seed cells, tissue engineering scaffolds and tissue construction. Tissue engineering three-dimensional porous scaffolds play an extremely important role in it, and scaffolds can be widely used in tissue repair, cell culture carriers, wound dressings, drug controlled release carriers and other fields. In particular, degradable porous polymer three-dimensional scaffolds with high porosity and good connectivity have been developed into an important par...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56
Inventor 丁建东潘震
Owner FUDAN UNIV
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