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Ophthalmic preparation containing oxygen micro-capsules and preparation method

An ophthalmic preparation and oxygen technology, applied in the field of corneal injury, can solve the problems of no precedents and reports of corneal oxygen supply, and achieve the effects of improving corneal hypoxia, preventing corneal injury, and accelerating treatment

Active Publication Date: 2013-03-20
李洪江
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] But so far, there are no precedents and reports of supplying oxygen to the cornea through oxygen microcapsules at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0027] The invention relates to an ophthalmic preparation containing oxygen microcapsules. The preparation contains a large number of oxygen microcapsules, and oxygen is also saturated and dissolved in the liquid. When instilled into the eye, there is sufficient oxygen in contact with the cornea, which can be absorbed and utilized by the cornea to maintain its normal physiological functions. Contact lens wearers will cause corneal edema and turbidity due to reduced corneal contact with oxygen. The present invention can solve this kind of corneal hypoxia problem.

[0028] The present invention can also be instilled through the outer eye, so that oxygen molecules enter the vitreous body through the outer eye, thereby supplying oxygen to the retina, improving the state of fundus hypoxia in diabetic patients, and inhibiting the expression of hypoxia-inducible factor-1α (HIF-1α). Inhibit the expression of vascular endothelial growth factor (VEGF), prevent the formation of diabetic ...

Embodiment 1

[0035] prescription:

[0036] 30% oxygen 500ml

[0037] Poloxamer 20.0g

[0038] Soy Lecithin 12.0g

[0039] Glycerin 12.5g

[0040] Carbomer 2.0g

[0041] Sodium hydroxide solution to adjust the pH to 7.2

[0042] water balance

[0043] Makes 1000ml.

[0044] Preparation method: Take the prescribed amount of carbomer and soak in water for 12 hours; take another glycerin, poloxamer, soybean lecithin and disperse evenly in water, combine with the carbomer solution, add water to 500ml, stir evenly, wash with sodium hydroxide The pH of the solution was adjusted to 7.3, and filtered through a 200-mesh stainless steel mesh. Adjust medical oxygen to a concentration of 30% oxygen content, pass it into the above solution, and stir at high speed while ventilating, so that the solution forms small microcapsules containing a large amount of oxygen, the volume is up to 1000ml, and then use a high-pressure homogenizer Homogenize to form stable oxygen microcapsules, dispense into plas...

Embodiment 2

[0046] prescription:

[0047] 45% oxygen 300ml

[0048] Poloxamer 15.0g

[0049] Soy Lecithin 12.0g

[0050] Sodium chloride 4.9g

[0051] Carbomer 2.0g

[0052] Sodium hydroxide solution to adjust the pH to 7.7

[0053] water 700ml

[0054] Makes 1000ml.

[0055] Preparation method: Take the prescribed amount of carbomer and soak in water for 12 hours, take another sodium chloride, poloxamer, soybean lecithin to dissolve and evenly disperse in water, combine with carbomer solution, add water to 700ml, stir evenly, Use sodium hydroxide solution to adjust the pH value to 7.4, filter through 200-mesh stainless steel mesh, sterilize at 121°C for 30 minutes, and cool to room temperature. Adjust medical oxygen to a concentration of 45% oxygen, pass through a 0.22μm microporous membrane, pass it into the above solution, and stir at high speed while ventilating, so that the solution forms small microcapsules containing a large amount of oxygen, with a volume of up to 1000ml T...

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Abstract

The invention relates to the field of an ophthalmic preparation containing oxygen micro-capsules. The ophthalmic preparation containing the oxygen micro-capsules is mainly used for preventing and treating various eye diseases caused by oxygen deficiency and is particularly suitable for corneal injury. The ophthalmic preparation containing the oxygen micro-capsules is characterized in that the preparation is a flowing semisolid gel preparation and comprises the following components of: oxygen accounting for 5-70% of the total volume of the preparation and having the concentration of 5-100%, a surface active agent accounting for 0.1-50% of the total weight of the preparation, an isoosmotic adjusting agent accounting for 0.1-2.5% of the total weight of the preparation, a thickening agent accounting for 0.1-40% of the total weight of the preparation, a certain amount of pH adjusting agent capable of adjusting the pH value of the preparation to be 6.8-8.6, and the balance of water. When corneas are injured and are in contact with little oxygen due to wearing of contact lens, the corneas are dropsical and turbid, and the ophthalmic preparation containing the oxygen micro-capsules aims at solving the problem of oxygen deficiency of the corneas by supplying oxygen for eyes through oxygen micro-capsules.

Description

technical field [0001] The invention relates to the field of ophthalmic preparations containing oxygen microcapsules, which are mainly used to prevent and treat various eye diseases caused by hypoxia, and are especially suitable for corneal damage. Background technique [0002] The cornea is the most transparent part of the eye, covering the iris, pupil and anterior chamber, and provides most of the refractive power of the eye. Coupled with the refractive power of the lens, the light can be accurately focused on the retina to form an image. [0003] The cornea has very sensitive nerve endings. If a foreign object touches the cornea, the eyelids will involuntarily close to protect the eyes. Since the cornea has no blood vessels, in order to maintain transparency, it obtains nutrients and oxygen through tears and aqueous humor. [0004] The cornea is divided into five layers, from front to back: epithelial cell layer (epithelium), anterior elastic layer (lamina elastica ante...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61K9/06A61K47/38A61K47/36A61K47/32A61K47/34A61P27/02
Inventor 李洪江才凤李双
Owner 李洪江
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