Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of dextran sulfate in preparing medicament for treating hepatic fibrosis

A technology of dextran sulfate and liver fibrosis, which is applied in the field of biomedicine, can solve the problems of inability to treat patients, increase the incidence of severe disease, and high mortality of patients, and achieve low price, suppress seizures or aggravation of symptoms, and have broad application prospects Effect

Inactive Publication Date: 2013-03-20
合肥博太医药生物技术发展有限公司
View PDF3 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with changes in people's lifestyles and eating habits, and the impact of chronic viral hepatitis, the incidence of severe disease has been increasing. The direct consequences of liver fibrosis are liver cirrhosis and liver failure, and the mortality rate of patients is extremely high. At the same time, there is a lack of effective Clinically, liver replacement is the best treatment option, but there is a serious shortage of liver donors, and most patients cannot be treated. Therefore, the development of effective therapeutic drugs is of great significance for the treatment of this disease.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0014] (Treatment of Dextran Sulfate Injection Solution Preparation on Carbon Tetrachloride-Induced Liver Fibrosis Model)

[0015] Dextran sulfate with different molecular weights and modification rates was dissolved in physiological saline to make 2.0 mg / ml injection solution for later use, and the pH value was adjusted to 7.0 with 10 mol / L NaOH solution. Seventy-eight female neo-ICR mice, weighing 18 g-20 g, were randomly divided into 13 groups, 6 in each group, namely the normal control group, liver fibrosis model group, and dextran sulfate with different molecular weights and modification rates. Sugar-treated treatment groups. The model was established by subcutaneously injecting 5 ml / kg body weight of 20% tea oil solution of carbon tetrachloride, once every 5 days, for 3 consecutive months, and the treatment group was treated with intraperitoneal injection of dextran sulfate every week. The drug-treated model group was injected with an equal volume of normal saline. Thr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention discloses novel application of dextran sulfate in preparing a medicament for treating hepatic fibrosis. The medicament can be used for inhibiting inflammatory reaction in hepatic fibrosis attaching process, so that attack or symptom worsening of hepatic fibrosis can be inhibited. Dextran sulfate has good curative effect in a carbon tetrachloride induced animal model; and the medicaments used in the application can be easily acquired, low in price and stable in properties, are convenient to store and transport, and have wide application prospect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of dextran sulfate in the preparation of medicines for treating liver fibrosis. Background technique [0002] Liver fibrosis is a disease that seriously affects people's life and health. In recent years, with changes in people's lifestyles and eating habits, and the impact of chronic viral hepatitis, the incidence of severe disease has been increasing. The direct consequences of liver fibrosis are liver cirrhosis and liver failure, and the mortality rate of patients is extremely high. At the same time, there is a lack of effective Clinically, liver replacement is the best treatment option, but liver donors are seriously insufficient, and most patients cannot be treated. Therefore, the development of effective therapeutic drugs is of great significance for the treatment of this disease. [0003] There are many causes of liver fibrosis. Viruses, dru...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/737A61P11/00
Inventor 董磊
Owner 合肥博太医药生物技术发展有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com