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Preparation method of tissue engineering scaffold material

A technology of tissue engineering scaffold and solution, which is applied in medical science, prosthesis, etc., and can solve problems such as poor connectivity between pores, poor mechanical strength of scaffolds, difficulty in controlling the diameter and density of channels between pores, etc.

Active Publication Date: 2013-03-13
CHANGCHUN SINOBIOMATERIALS
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These methods have achieved varying degrees of success, but there are generally problems with poor connectivity between holes, such as figure 1
Ma P.X. is equal to the preparation process of the biodegradable polymer scaffold with a well-defined interconnected spherical pore network prepared by the method of particle fusion reported by Tissue Eng7:23, 2001. Although the penetration between the pores is increased, the pores of this method It is difficult to control the channel diameter and channel density, and the mechanical strength of the scaffold is poor

Method used

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  • Preparation method of tissue engineering scaffold material
  • Preparation method of tissue engineering scaffold material
  • Preparation method of tissue engineering scaffold material

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preparation example Construction

[0033] A kind of preparation method of tissue engineering scaffold material provided by the present invention comprises:

[0034] a) mixing the biocompatible polyester with a non-polar solvent to obtain a first solution;

[0035] b) adding a phase inversion solvent into the first mixed solution to obtain a second solution;

[0036] c) placing the second solution in a mold, removing the non-polar solvent and phase inversion solvent through a liquid-gas phase or liquid-solid phase inversion process, and drying the solute. Obtain tissue engineering scaffold materials.

[0037] In order to solve the problems of the prior art and make the tissue engineering scaffold material have high strength and controllable porosity and void size, the present invention uses a phase inversion method to prepare the first biocompatible polyester for preparing the tissue engineering scaffold material by dissolving solution, and then add a phase inversion solvent to the first solution to obtain a s...

Embodiment 1

[0050] Dissolve polyester polymer polylactic acid (PLA) in chloroform; add DMF with a volume ratio of 3:2 to chloroform into the polymer solution; wait for the polymer solution to evaporate at room temperature for several days to form a relatively dry solid; The block was placed in three-distilled water with a negative pressure of 10 MP and washed several times until there was no solvent or porogen in the aqueous solution after washing; it was dried in vacuum, and the morphology of the scaffold was detected by field emission scanning electron microscopy (ESEM). Such as figure 1 .

Embodiment 2

[0052] Dissolve polyester polymer polylactic acid (PLA) in chloroform; add DMF with a volume ratio of 2:3 to chloroform to the polymer solution; add a particle size of 200 μm with a mass ratio of 9:1 to PLA in the mold sucrose granules; pour the dual-solvent polymer solution into the mold filled with sucrose granules; wait for the polymer solution to evaporate at room temperature for several days to form a relatively dry solid; put the solid block into three-distilled water with a negative pressure of 10MP and wash it several times , until there is no more solvent or porogen in the aqueous solution after washing; vacuum drying, and field emission scanning electron microscopy (ESEM) to detect the morphology of the scaffold. Such as figure 2 .

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Abstract

The invention provides a preparation method of a tissue engineering scaffold material. The preparation method comprises the following steps: mixing biocompatible polyester with a non-polar solvent to get a first solution; adding a phase inversion solvent into the first mixed solution to get a second solution; and removing the non-polar solvent and the phase inversion solvent of the second solution in a mold through a liquid-gas phase conversion process or / and a liquid-solid phase conversion process, and drying a solute, thus obtaining the tissue engineering scaffold material. According to the method for preparing the tissue engineering scaffold material, a tissue engineering scaffold has high porosity on the basis of good mechanical properties.

Description

technical field [0001] The invention relates to the field of preparation of polymer materials, in particular to a preparation method of a tissue engineering scaffold material, Background technique [0002] Tissue engineering scaffold material is a polymer material that can partially or completely replace human tissues and organs. Because of its good biocompatibility, non-toxic and harmless, it has been widely used in organ replacement, organ transplantation, clinical surgery and other fields. [0003] For tissue engineering scaffold materials, in addition to requiring high porosity, there are also strict requirements on pore size. If the pores are too small, cells cannot enter the pores or hinder cell reproduction and expansion. If the pores are too large, cells are not easy to adhere and lose their function. The role of the scaffold. Now there are many different preparation methods for tissue engineering scaffolds, including molding method, gas foaming method, solution cas...

Claims

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Application Information

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IPC IPC(8): A61L27/18
CPCA61L27/18A61L27/56C08L67/04
Inventor 陈学思崔立国章培标高战团王宗良王宇
Owner CHANGCHUN SINOBIOMATERIALS
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