Anti-brain-tumor drug

A technology for drugs and brain tumors, which is applied in the direction of antineoplastic drugs, drug combinations, and pharmaceutical formulations, and can solve problems such as limiting the dosage and not being able to fully obtain the pharmacological effects of anticancer drugs

Inactive Publication Date: 2013-02-13
IHI CORP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since these side effects become a heavy burden on patients, the dosage must be limited, and there is a problem that the pharmacological effects of anticancer agents cannot be sufficiently obtained.

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0028]

[0029] step 1:

[0030] Put 25g, 0.18mol of 4-nitrophenol (4-nitrophenol; compound 1 (compound 1)), 25g, 0.18mol of hexamethylene tetramine (hexamethylene tetramine), 200ml of polyphosphoric acid (polyphosphoric acid) mixture in Stir at 100°C for 1 hour. The mixture was then poured into 500 ml of ethyl acetate and 1 L (liter) of water, and stirred until completely dissolved. Further, 400 ml of ethyl acetate was added to the solution, and as a result, the solution separated into two phases. Next, the aqueous phase was removed from the solution separated into two phases, the remaining compound was washed twice with an alkaline solvent, and washed with anhydrous MgSO 4 (Magnesium sulfate) was dried, and as a result, 17 g (57% yield) of compound 2 was synthesized.

[0031] Step 2:

[0032] 17g, 0.10mol of compound 2 (compound 2), 200ml of acetic anhydride (acetic anhydride), a small amount of H 2 SO 4 Stir at room temperature for 1 hour. The resulting solutio...

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Abstract

Disclosed is a drug that contains as the primary component a metal-salen complex compound that is effective against brain tumors. The anti-brain-tumor drug contains a metal-salen complex compound represented by the belowmentioned chemical formula (I). In the formula, M is a metal atom comprising Fe, Cr, Mn, Co, Ni, Mo, Ru, Rh, Pd, W, Re, Os, Ir, Pt, Nd, Sm, Eu, or Gd, and X is a halogen atom.

Description

technical field [0001] The present invention relates to anti-brain tumor drugs. Background technique [0002] After a drug is administered to a living body, it reaches an affected area and exhibits a therapeutic effect by exerting a pharmacological effect on the affected area. On the other hand, even if the drug reaches tissues other than the affected part (that is, normal tissues), it not only fails to treat but also causes side effects. [0003] Therefore, how to effectively guide the drug to the affected area is very important in the treatment strategy. The technology of introducing drugs to the affected area in this way is called drug delivery and has been actively researched and developed in recent years. This drug delivery has at least two advantages. [0004] One is that a sufficiently high drug concentration can be obtained in the affected tissue. This is because no pharmacological effect is exhibited when the concentration of the drug in the affected area is les...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/555A61P35/00C07C251/24C07F15/02
CPCC07F15/0013C07F13/005C07C251/24C07F15/025A61P35/00
Inventor 石川义弘江口晴树
Owner IHI CORP
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