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Fluorescence sensor

A fluorescent sensor and light quantity technology, applied in the field of fluorescent sensors, can solve the problems of shortening the life of the sensor and fast deterioration of the indicator

Inactive Publication Date: 2013-02-13
TERUMO KK
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In the fluorescent sensor 110, the excitation light E is condensed near the upper part of the photoelectric conversion element portion 103 of the indicator layer 106, and therefore, the deterioration rate of the indicator at the condensed place is fast, which may shorten the lifetime of the entire sensor.

Method used

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Experimental program
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no. 1 approach

[0027] Next, a fluorescence sensor 10 according to a first embodiment of the present invention will be described with reference to the drawings. Such as image 3 and Figure 4 As shown, the fluorescence sensor 10 of this embodiment has: a silicon substrate 11 as a main substrate; and a light emitting element substrate ( Hereinafter referred to as "LED substrate") 15, transparent resin layer 16, indicator layer 17, and light-shielding layer 18, in which the reflective film 20 is a light-quantity equalization portion that makes the light-quantity distribution of emitted excitation light uniform. A photodiode element (hereinafter referred to as “PD element”) 12 as a photoelectric conversion element is formed on a silicon substrate 11 . A light-emitting diode element (hereinafter referred to as "LED element") 15C, which is a light-emitting element that generates excitation light E, is formed substantially at the center of first principal surface 15A of LED substrate 15 through w...

no. 2 approach

[0070]Next, a fluorescence sensor 10B according to the second embodiment will be described. Since the fluorescence sensor 10B is similar to the fluorescence sensor 10 , the components with the same functions are given the same numerals and their descriptions are omitted. The light quantity equalizing portion of the fluorescence sensor 10B is a light-shielding film 22 formed on at least a region of the second main surface 15B facing the LED element 15C and having a function of absorbing excitation light. The light-shielding film 22 is an excitation light attenuation portion that attenuates the light intensity in a region where the light intensity distribution has a large light intensity.

[0071] That is, if Figure 9 As shown, compared with the case of "(A) without a light-shielding film", in the case of "(B) with a reflective film", the amount of light in the central area decreases, while the amount of light in the peripheral area does not change. The light-shielding film 2...

no. 3 approach

[0075] Next, a fluorescence sensor 10C according to the third embodiment will be described. Since the fluorescence sensor 10C is similar to the fluorescence sensor 10 , components with the same functions are assigned the same numerals and descriptions thereof are omitted.

[0076] Such as Figure 10 As shown, the fluorescence sensor 10C has a main substrate 25 having a recess 33 , an LED substrate 15 provided with a reflective film 20 , a transparent resin layer 16C, an indicator layer 17C, and a light shielding layer 18C. The LED substrate 15 , the transparent resin layer 16C, and the indicator layer 17C are disposed inside the recess 33 , and the light-shielding layer 18C is disposed so as to close the opening of the recess 33 .

[0077] The main substrate 25 is manufactured by bonding a wiring substrate 30 having various wiring layers not shown and a rectangular prism-shaped frame-shaped substrate 40 having a through hole in the center. Therefore, in the main substrate 25...

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Abstract

A fluorescence sensor 10 includes a silicon substrate 11 on which a PD element 12 that converts fluorescence into an electric signal is formed, an LED substrate 15 having a first principal plane 15A on which an LED element 15C that generates excitation light is formed, a reflective film 20 that averages a light amount distribution of the excitation light radiated from a second principal plane 15B of the LED substrate 15, and an indicator layer 17 that receives the excitation light averaged by the reflective film 20 and generates the fluorescence having a light amount corresponding to an analyte amount.

Description

technical field [0001] The present invention relates to a fluorescent sensor for measuring the concentration of an analyte, in particular to a fluorescent sensor with an indicator, which generates fluorescence corresponding to the concentration of the analyte by irradiation with excitation light. Background technique [0002] A wide variety of analytical devices have been developed for determining the concentration of an analyte, ie, a substance to be measured, in a liquid. For example, a fluorescent sensor is known, which injects a fluorescent dye whose property changes due to the presence of an analyte and generates fluorescence, and a solution to be measured containing the analyte into a transparent container of a certain volume, and measures the amount of light from the fluorescent light by irradiating excitation light. The fluorescence intensity of the dye is used to measure the analyte concentration. [0003] In addition, a small fluorescent sensor has a light source,...

Claims

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Application Information

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IPC IPC(8): G01N21/77
CPCA61B5/14532G02B6/42A61B5/14539A61B5/14556G01N21/6428G01N2021/7786G01N21/77G01N2021/7753A61B5/0071G01N33/582G01N21/6454A61B2562/0233G01N21/645G01N21/6489
Inventor 前江田和也松本淳
Owner TERUMO KK
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