Preparation method of artificial antigen applied to tartrazine
A technology of artificial antigen and tartrazine, which is applied to the preparation method of peptides, chemical instruments and methods, animal/human protein, etc., can solve the problems that cannot meet the requirements of fast, convenient and accurate, and achieve the effect of simple synthesis steps
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[0031] (1) Preparation of tartrazine derivatives
[0032] Using succinic acid monoethyl chloride and 2,2-dimethyl-1,2-dioxane-4,6-dione as raw materials, after 4 steps of chemical reaction, tartrazine derivative TAR was prepared. The chemical synthesis steps are as follows:
[0033] Synthesis of diethyl 3-ketoadipate:
[0034]Take succinic acid monoethyl chloride (11.4g, 69.59mmol) and dissolve it in dichloromethane solution, and then add it dropwise within 1h to the stirring 2, 2-Dimethyl-1,2-dioxane-4,6-dione (8.98g, 62.33mmol) in the solution of Meldrum's acid, and then continue to stir for 1h. The reaction mixture was purified and concentrated to obtain diethyl 3-ketoadipate (13.4 g, 88%).
[0035] Synthesis of ethyl 1-phenyl-5-pyrazolone-3-propionate:
[0036] Diethyl 3-ketoadipate (13.4 g, 61.98 mmol) was dissolved in 200 ml of pure ethanol solution, and then phenylhydrazine hydrochloride (10.755 g, 74.38 mmol) was added to the solution in batches at room temp...
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